Zobrazeno 1 - 10
of 70
pro vyhledávání: '"Laurent Brino"'
Autor:
Amit Kulkarni, Tiago Ferreira, Clemens Bretscher, Annabel Grewenig, Nazim El-Andaloussi, Serena Bonifati, Tiina Marttila, Valérie Palissot, Jubayer A. Hossain, Francisco Azuaje, Hrvoje Miletic, Lars A. R. Ystaas, Anna Golebiewska, Simone P. Niclou, Ralf Roeth, Beate Niesler, Amélie Weiss, Laurent Brino, Antonio Marchini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Rat H-1 parvovirus (H-1PV) is in clinical development for oncolytic therapy. Here, Kulkarni et al. identify LAMC1 as a modulator of H-1PV cell attachment and entry and find that LAMC1 levels and H-1PV oncolytic activity correlate in 59 tested cancer
Externí odkaz:
https://doaj.org/article/e9d685fa483d413282b0592f44b963bf
Autor:
Aurore Vuidel, Loïc Cousin, Beatrice Weykopf, Simone Haupt, Zahra Hanifehlou, Nicolas Wiest-Daesslé, Michaela Segschneider, Joohyun Lee, Yong-Jun Kwon, Michael Peitz, Arnaud Ogier, Laurent Brino, Oliver Brüstle, Peter Sommer, Johannes H. Wilbertz
Publikováno v:
Stem Cell Reports. 17:2349-2364
Combining multiple Parkinson's disease (PD) relevant cellular phenotypes might increase the accuracy of midbrain dopaminergic neuron (mDAN) in vitro models. We differentiated patient-derived induced pluripotent stem cells (iPSCs) with a LRRK2 G2019S
Autor:
Eliana MC Tacconi, Sophie Badie, Giuliana De Gregoriis, Timo Reisländer, Xianning Lai, Manuela Porru, Cecilia Folio, John Moore, Arnaud Kopp, Júlia Baguña Torres, Deborah Sneddon, Marcus Green, Simon Dedic, Jonathan W Lee, Ankita Sati Batra, Oscar M Rueda, Alejandra Bruna, Carlo Leonetti, Carlos Caldas, Bart Cornelissen, Laurent Brino, Anderson Ryan, Annamaria Biroccio, Madalena Tarsounas
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 7, Pp n/a-n/a (2019)
Abstract Due to compromised homologous recombination (HR) repair, BRCA1‐ and BRCA2‐mutated tumours accumulate DNA damage and genomic rearrangements conducive of tumour progression. To identify drugs that target specifically BRCA2‐deficient cell
Externí odkaz:
https://doaj.org/article/60b26d5b1f0d4fb1965e8459d8be9b33
Autor:
Srinivas Niranj Chandrasekaran, Jeanelle Ackerman, Eric Alix, D. Michael Ando, John Arevalo, Melissa Bennion, Nicolas Boisseau, Adriana Borowa, Justin D. Boyd, Laurent Brino, Patrick J. Byrne, Hugo Ceulemans, Carolyn Ch’ng, Beth A. Cimini, Djork-Arne Clevert, Nicole Deflaux, John G Doench, Thierry Dorval, Regis Doyonnas, Vincenza Dragone, Ola Engkvist, Patrick W. Faloon, Briana Fritchman, Florian Fuchs, Sakshi Garg, Tamara J. Gilbert, David Glazer, David Gnutt, Amy Goodale, Jeremy Grignard, Judith Guenther, Yu Han, Zahra Hanifehlou, Santosh Hariharan, Desiree Hernandez, Shane R Horman, Gisela Hormel, Michael Huntley, Ilknur Icke, Makiyo Iida, Christina B. Jacob, Steffen Jaensch, Jawahar Khetan, Maria Kost-Alimova, Tomasz Krawiec, Daniel Kuhn, Charles-Hugues Lardeau, Amanda Lembke, Francis Lin, Kevin D. Little, Kenneth R. Lofstrom, Sofia Lotfi, David J. Logan, Yi Luo, Franck Madoux, Paula A. Marin Zapata, Brittany A. Marion, Glynn Martin, Nicola Jane McCarthy, Lewis Mervin, Lisa Miller, Haseeb Mohamed, Tiziana Monteverde, Elizabeth Mouchet, Barbara Nicke, Arnaud Ogier, Anne-Laure Ong, Marc Osterland, Magdalena Otrocka, Pieter J. Peeters, James Pilling, Stefan Prechtl, Chen Qian, Krzysztof Rataj, David E Root, Sylvie K. Sakata, Simon Scrace, Hajime Shimizu, David Simon, Peter Sommer, Craig Spruiell, Iffat Sumia, Susanne E Swalley, Hiroki Terauchi, Amandine Thibaudeau, Amy Unruh, Jelle Van de Waeter, Michiel Van Dyck, Carlo van Staden, Michał Warchoł, Erin Weisbart, Amélie Weiss, Nicolas Wiest-Daessle, Guy Williams, Shan Yu, Bolek Zapiec, Marek Żyła, Shantanu Singh, Anne E. Carpenter
Image-based profiling has emerged as a powerful technology for various steps in basic biological and pharmaceutical discovery, but the community has lacked a large, public reference set of data from chemical and genetic perturbations. Here we present
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ad294298f87b0d35776a491fba28d7f
https://doi.org/10.1101/2023.03.23.534023
https://doi.org/10.1101/2023.03.23.534023
Autor:
Vivien Batoumeni, Yeranuhi Hovhannisyan, Bénédicte Gobert, David Hoffmann, Keyhan Alvandipour, Nicolas Wiest-Daesslé, Laurent Brino, Peter Sommer, Konstantinos Gkatzis, Pierre Joanne, Onnik Agbulut
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 15:206-207
Autor:
Eloi R Verrier, Gaëtan Ligat, Laura Heydmann, Katharina Doernbrack, Julija Miller, Anne Maglott-Roth, Frank Jühling, Houssein El Saghire, Margaux J Heuschkel, Naoto Fujiwara, Sen-Yung Hsieh, Yujin Hoshida, David E Root, Emanuele Felli, Patrick Pessaux, Atish Mukherji, Laurent Mailly, Catherine Schuster, Laurent Brino, Michael Nassal, Thomas F. Baumert
ObjectivesChronic hepatitis B virus (HBV) infection is a leading cause of liver disease and hepatocellular carcinoma. A key feature of HBV replication is the synthesis of the covalently close circular (ccc)DNA, not targeted by current treatments and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7684cf9828d9f6e8f87b191ad352841c
Autor:
Alkmini Kalousi, Anne-Sophie Hoffbeck, Platonas N. Selemenakis, Jordan Pinder, Kienan I. Savage, Kum Kum Khanna, Laurent Brino, Graham Dellaire, Vassilis G. Gorgoulis, Evi Soutoglou
Publikováno v:
Cell Reports, Vol 11, Iss 1, Pp 149-163 (2015)
Cells experience damage from exogenous and endogenous sources that endanger genome stability. Several cellular pathways have evolved to detect DNA damage and mediate its repair. Although many proteins have been implicated in these processes, only rec
Externí odkaz:
https://doaj.org/article/cc2a41e5007e4ca08930877ab8c04887
Autor:
Sylvie Job, Aurélien de Reyniès, Betty Heller, Amélie Weiss, Eric Guérin, Christine Macabre, Sonia Ledrappier, Cyril Bour, Christine Wasylyk, Nelly Etienne-Selloum, Laurent Brino, Christian Gaiddon, Bohdan Wasylyk, Alain C. Jung
Publikováno v:
Cancers, Vol 11, Iss 6, p 795 (2019)
The management of locally advanced head and neck squamous cell carcinoma (HNSCC) with Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), achieves only moderate response rates, and clinical trials that evaluated EG
Externí odkaz:
https://doaj.org/article/2e9ea06ac13e44eea8155232517ffc14
Autor:
Aurore Vuidel, Loïc Cousin, Beatrice Weykopf, Simone Haupt, Zahra Hanifehlou, Nicolas Wiest-Daesslé, Michaela Segschneider, Michael Peitz, Arnaud Ogier, Laurent Brino, Oliver Brüstle, Peter Sommer, Johannes H. Wilbertz
SummaryCombining multiple Parkinson’s disease (PD) relevant cellular phenotypes might increase the accuracy of midbrain dopaminergic (mDA) in vitro models. We differentiated patient-derived induced pluripotent stem cells (iPSCs) with a LRRK2 G2019S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::667eede02d200f65a3679bbcb6c7f23c
https://doi.org/10.1101/2022.03.01.482490
https://doi.org/10.1101/2022.03.01.482490
Autor:
Arantxa Agote-Arán, Matej Durik, Izabela Sumara, Charlotte Kleiss, Sadek Fournane, Radislav Sedlacek, Katerina Jerabkova, Laurent Brino, Yongrong Liao
Publikováno v:
FASEB Journal
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (9), pp.12751-12767. ⟨10.1096/fj.202000769R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (9), pp.12751-12767. ⟨10.1096/fj.202000769r⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (9), pp.12751-12767. ⟨10.1096/fj.202000769R⟩
FASEB Journal, Federation of American Society of Experimental Biology, 2020, 34 (9), pp.12751-12767. ⟨10.1096/fj.202000769r⟩
International audience; Equal segregation of chromosomes during mitosis ensures euploidy of daughter cells. Defects in this process may result in an imbalance in the chromosomal composition and cellular transformation. Proteolytic and non‐proteolyt