Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Laurent Boursier"'
Autor:
Pritash Patel, Michael Escudier, Stephen Challacombe, Francesca Barone, Carlo Nunes, Jo Spencer, Jeremy D. Sanderson, Edward Odell, Laurent Boursier, Jonathan Brostoff
Publikováno v:
Inflammatory Bowel Diseases. 16:1051-1060
Background: Orofacial granulomatosis (OFG) is a chronic, disfiguring, granulomatous inflammation of the lips and oral mucosa. The pathogenesis is unknown, but it has been linked previously to Crohn's disease (CD) and more recently to dietary sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78b6cc3426bc7fe60133b0eb218c9897
https://doi.org/10.1002/ibd.21169
https://doi.org/10.1002/ibd.21169
Publikováno v:
Lupus. 19:1161-1170
Affinity maturation is a process by which low-affinity antibodies are transformed into highly specific antibodies in germinal centres. This process occurs by hypermutation of immunoglobulin heavy chain variable (IgH V) region genes followed by select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f7dd9f2090c58af765e0c18a8776b83
https://doi.org/10.1177/0961203310367657
https://doi.org/10.1177/0961203310367657
Autor:
Jo Spencer, John N. Gordon, Laurent Boursier, Sivashankari Thiagamoorthy, Jonathan D. Edgeworth
Publikováno v:
Gastroenterology. 128:1879-1889
Background & Aims: The intestinal lamina propria has traditionally been viewed as the effector site of mucosal immune responses. However, this view has been challenged with the identification, in the murine lamina propria, of an in situ class switch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da7e29877ea8c54870e749fdc3a13880
https://doi.org/10.1053/j.gastro.2005.03.047
https://doi.org/10.1053/j.gastro.2005.03.047
Publikováno v:
Molecular Immunology. 40:1273-1278
Somatic hypermutation. which diversifies the immunoglobulin repertoire by introducing mutations into rearranged IgV genes, is dependent on the expression of activation-induced cytidine deaminase (AID). It has been proposed that AID deaminates DNA dir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cc6088c48c119341a6b52c05ea923a9
https://doi.org/10.1016/j.molimm.2003.11.026
https://doi.org/10.1016/j.molimm.2003.11.026
Publikováno v:
European Journal of Immunology. 32:2427-2436
The contribution of peritoneal B cells to the intestinal lamina propria plasma cell population is well documented in mice, but unknown in humans. We have analyzed immunoglobulin (Ig) genes of human peritoneal B cells, because such genes show distinct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::231491bed922c252db7955deba6e0cf2
https://doi.org/10.1002/1521-4141(200209)32:9<2427::aid-immu2427>3.0.co
https://doi.org/10.1002/1521-4141(200209)32:9<2427::aid-immu2427>3.0.co
Publikováno v:
Molecular Immunology. 37:107-113
Immunoglobulins are known to be variably glycosylated. Although most carbohydrate is likely to be associated with the constant region, the variable region may also be glycosylated. Variable region glycosylation is known to be associated with antigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7adc22a842916dde2500cfc5e8aa8a90
https://doi.org/10.1016/s0161-5890(00)00038-9
https://doi.org/10.1016/s0161-5890(00)00038-9
Autor:
R.C. Ratnavel, Eduardo Calonje, Deborah K. Dunn-Walters, Laurent Boursier, Robin Russell-Jones, E. Frazer-Andrews, G. Orchard
Publikováno v:
British Journal of Dermatology. 140:708-714
The term Richter's syndrome is used to describe the transformation of chronic lymphatic leukaemia (CLL) into a high-grade systemic lymphoma and is associated with a poor prognosis. We have undertaken detailed molecular studies in two patients with cu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f7842cd2efca9d54e740f508af1d844
https://doi.org/10.1046/j.1365-2133.1999.02776.x
https://doi.org/10.1046/j.1365-2133.1999.02776.x
Publikováno v:
Human Pathology. 29:585-593
Splenic marginal zone lymphoma (SMZL) is a low-grade primary splenic B cell lymphoma, originally thought to be related to splenic marginal zone B cells. Later studies showed that SMZL sometimes may be accompanied by villous lymphocytes in the periphe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1570c0ac5fc85368cf235d08a197f848
https://doi.org/10.1016/s0046-8177(98)80007-5
https://doi.org/10.1016/s0046-8177(98)80007-5
Publikováno v:
European Journal of Immunology. 27:2959-2964
In this work we have microdissected lamina propria plasma cells and used polymerase chain reaction and sequencing to investigate immunoglobulin (Ig) gene rearrangements and mutations in human intestine. In addition, specific primers were designed for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c4b228e943fcb1bccf62986b85555dc
https://doi.org/10.1002/eji.1830271131
https://doi.org/10.1002/eji.1830271131
Autor:
Alan R. Watson, Sonali Wijetilleka, Laurent Boursier, Paul Fields, Susan D. John, Francesca Barone, Jo Spencer, Wen Su, Anna Vossenkämper, Jonathan D. Edgeworth, Deborah K. Dunn-Walters
Publikováno v:
Gastroenterology
BACKGROUND & AIMS: Immunoglobulin (Ig)A contributes to the homeostatic balance between host and the intestinal microbiota. Mechanisms that initiate the IgA response are unclear and likely to differ between humans and animal models. We used multiple e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::690d41f688f76964f1f08e9ac2818ce8
https://pubmed.ncbi.nlm.nih.gov/21147106
https://pubmed.ncbi.nlm.nih.gov/21147106