Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Laurent Bonnac"'
Publikováno v:
Viruses, Vol 13, Iss 667, p 667 (2021)
Viruses
Viruses
The emergence or re-emergence of viruses with epidemic and/or pandemic potential, such as Ebola, Zika, Middle East Respiratory Syndrome (MERS-CoV), Severe Acute Respiratory Syndrome Coronavirus 1 and 2 (SARS and SARS-CoV-2) viruses, or new strains of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b098841ad232770cad8f131898d5c57
https://www.mdpi.com/1999-4915/13/4/667
https://www.mdpi.com/1999-4915/13/4/667
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 30:126819
Twenty-nine nucleoside analogues have been synthesized and evaluated in a cell based assay for their ability to activate the human Stimulator of Interferon Genes (hSTING), a key protein of the innate immune defense. Some 6-O-alkyl nucleoside analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8486b7afc852115c1458c06fc2a64430
https://doi.org/10.1016/j.bmcl.2019.126819
https://doi.org/10.1016/j.bmcl.2019.126819
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 12, Iss 4, p e0006421 (2018)
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases
Dengue virus affects millions of people worldwide each year. To date, there is no drug for the treatment of dengue-associated disease. Nucleosides are effective antivirals and work by inhibiting the accurate replication of the viral genome. Nucleobas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad0c26b7b53c7c61b337a34284d3b3a
http://europepmc.org/articles/PMC5929572?pdf=render
http://europepmc.org/articles/PMC5929572?pdf=render
Publikováno v:
Antiviral Chemistry and Chemotherapy. 23:223-230
Background: Over 25 drugs have been approved for the treatment of HIV-1 replication. All but one of these drugs is delivered as an oral medication. Previous studies have demonstrated that two drugs, decitabine and gemcitabine, have potent anti-HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2fcdcd8c8a93edbfeace53a4799f9c
https://doi.org/10.3851/imp2682
https://doi.org/10.3851/imp2682
Publikováno v:
Journal of Virology. 88:354-363
Reverse transcription is an important early step in retrovirus replication and is a key point targeted by evolutionarily conserved host restriction factors (e.g., APOBEC3G, SamHD1). Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (R
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f40637d12016f74cd1daeb4d44c7d64d
https://doi.org/10.1128/jvi.02444-13
https://doi.org/10.1128/jvi.02444-13
Autor:
Laurent Bonnac, Emma S. Child, Véronique Gouverneur, David J. Mann, Sarah E. Lee, Alexandra Anderson, Lucy M. Elphick
We hereby present a simple yet novel chemical synthesis of a family of γ-modified ATPs bearing functional groups on the γ-phosphate that are amenable to further derivatization by highly selective chemical manipulations (e.g., click chemistry, Staud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b422ba36ac18c24fae6e7feb194f00
https://doi.org/10.1016/j.bmcl.2009.04.028
https://doi.org/10.1016/j.bmcl.2009.04.028
Autor:
Jonathan M.O. Rawson, Louis M. Mansky, Michele B. Daly, Cavan S. Reilly, Jiashu Xie, Baek Kim, Laurent Bonnac, Sean R. Landman, Christine L. Clouser, Steven E. Patterson
5-Azacytidine (5-aza-C) is a ribonucleoside analog that induces the lethal mutagenesis of human immunodeficiency virus type 1 (HIV-1) by causing predominantly G-to-C transversions during reverse transcription. 5-Aza-C could potentially act primarily
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6e4c4493bf00d75637b2ea6e01b77cd
https://europepmc.org/articles/PMC4808159/
https://europepmc.org/articles/PMC4808159/
Autor:
José Maldonado, Steven E. Patterson, Baek Kim, Laurent Bonnac, Megan E. Roth, Michele B. Daly, Jiashu Xie, Christine L. Clouser, Louis M. Mansky
Publikováno v:
Retrovirology
Background HIV-1 replication kinetics inherently depends on the availability of cellular dNTPs for viral DNA synthesis. In activated CD4+ T cells and other rapidly dividing cells, the concentrations of dNTPs are high and HIV-1 reverse transcription o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c574ad819e266d30b1e4425d0b9f0ad
https://doi.org/10.1186/s12977-016-0254-0
https://doi.org/10.1186/s12977-016-0254-0
Autor:
Jonathan M.O. Rawson, Cavan S. Reilly, Baek Kim, Laurent Bonnac, Sean R. Landman, Jiashu Xie, Louis M. Mansky, Steven E. Patterson, Christine L. Clouser, Megan E. Roth, Michele B. Daly
Publikováno v:
Bioorganicmedicinal chemistry. 24(11)
Although many compounds have been approved for the treatment of human immunodeficiency type-1 (HIV-1) infection, additional anti-HIV-1 drugs (particularly those belonging to new drug classes) are still needed due to issues such as long-term drug-asso
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::186818751ebc77298b3d72512b960189
https://pubmed.ncbi.nlm.nih.gov/27117260
https://pubmed.ncbi.nlm.nih.gov/27117260
Autor:
Véronique Gouverneur, Laurent Bonnac, Alexandra Anderson, David J. Mann, Lucy M. Elphick, Emma S. Child, Sarah E. Lee
Publikováno v:
Future Medicinal Chemistry. 1:1233-1241
The protein kinase superfamily is one of the most important families of enzymes in molecular biology. Protein kinases typically catalyze the transfer of the -phosphate from ATP to a protein substrate (a highly ubiquitous cellular reaction), thereby c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e39c06ca62e79533137e945666a0f50
https://doi.org/10.4155/fmc.09.50
https://doi.org/10.4155/fmc.09.50