Alpha-6 integrin promotes radioresistance of glioblastoma by modulating DNA damage response and the transcription factor Zeb1

Autor: Aline Kowalski-Chauvel, Anouchka Modesto, Valerie Gouaze-andersson, Laurent Baricault, Julia Gilhodes, Caroline Delmas, Anthony Lemarie, Christine Toulas, Elizabeth Cohen-Jonathan-Moyal, Catherine Seva

Publikováno v: Cell Death & Disease
Cell Death and Disease, Vol 9, Iss 9, Pp 1-12 (2018)

Radiotherapy is the cornerstone of glioblastoma (GBM) standard treatment. However, radioresistance of cancer cells leads to an inevitable recurrence. In the present study, we showed that blocking α6-integrin in cells derived from GBM biopsy specimen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::a2b0f8523180902abb4a727a68f80e9c
http://europepmc.org/articles/PMC6115442

OPA1 alternate splicing uncouples an evolutionary conserved function in mitochondrial fusion from a vertebrate restricted function in apoptosis.: OPA1 isoforms in mitochondrial fusion or apoptosis

Autor: Pascale Belenguer, Laurent Baricault, Cécile Delettre, Aurélien Olichon, Ghizlane Elachouri, Guy Lenaers

Publikováno v: Cell Death and Differentiation
Cell Death and Differentiation, Nature Publishing Group, 2007, 14 (4), pp.682-92. ⟨10.1038/sj.cdd.4402048⟩

In most eucaryote cells, release of apoptotic proteins from mitochondria involves fission of the mitochondrial network and drastic remodelling of the cristae structures. The intramitochondrial dynamin OPA1, as a potential central actor of these proce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffb007fda9055c42bc24afae26dfe88e
https://doi.org/10.1038/sj.cdd.4402048

Loss of OPA1 Perturbates the Mitochondrial Inner Membrane Structure and Integrity, Leading to Cytochrome c Release and Apoptosis

Autor: Laurent Baricault, Pascale Belenguer, Annie Valette, Guy Lenaers, Emmanuelle Guillou, Aurélien Olichon, Nicole Gas

Publikováno v: Journal of Biological Chemistry. 278:7743-7746

OPA1 encodes a large GTPase related to dynamins, anchored to the mitochondrial cristae inner membrane, facing the intermembrane space. OPA1 haplo-insufficiency is responsible for the most common form of autosomal dominant optic atrophy (ADOA, MIM1655

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed98f921eab83d121d1a522f8493b2dc
https://doi.org/10.1074/jbc.c200677200

OPA1 cleavage depends on decreased mitochondrial ATP level and bivalent metals

Autor: Annie Valette, Laurie Guégand, Aurélien Olichon, Laurent Baricault, Florence Larminat, Bruno Ségui, Guy Lenaers

Publikováno v: Experimental Cell Research
Experimental Cell Research, Elsevier, 2007, 313 (17), pp.3800-8. ⟨10.1016/j.yexcr.2007.08.008⟩
Experimental Cell Research, 2007, 313 (17), pp.3800-8. ⟨10.1016/j.yexcr.2007.08.008⟩

International audience; OPA1, an intra-mitochondrial dynamin GTPase, is a key actor of outer and inner mitochondrial membrane dynamic. OPA1 amino-terminal cleavage by PARL and m-AAA proteases was recently proposed to participate to the mitochondrial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41f94f81e5ae937a41b6f23ce815640b
https://pubmed.ncbi.nlm.nih.gov/17826766

Fungal lectin, XCL, is internalized via clathrin-dependent endocytosis and facilitates uptake of other molecules

Autor: Didier Fournier, Claire Marty-Detraves, Frédéric Francis, Laurent Baricault, Renaud Poincloux, Laurent Paquereau

Publikováno v: European Journal of Cell Biology
European Journal of Cell Biology, Elsevier, 2003, 82 (10), pp.515-22

The lectin isolated from Xerocomus chrysenteron (XCL) displays a toxic activity towards insects. In order to assess its possible mode of action and to gather useful data for its potential use in insect-resistant transgenic plants, we investigated the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dae72390fd628b8ab3098e875a6d457
https://hal.archives-ouvertes.fr/hal-00177744