Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Laurent El Kaïm"'
Publikováno v:
Frontiers in Chemistry, Vol 7 (2019)
We report here selective Tsuji-Trost type allylation of Ugi adducts using a strategy based on the enhanced nucleophilicity of amide dianions. Ugi adducts derived from aromatic aldehydes were easily allylated at their peptidyl position with allyl acet
Externí odkaz:
https://doaj.org/article/c59be7122df9414db0f8ec60a863d500
Autor:
Nicolas Fincias, Louis Clavier, Mansour Dole Kerim, Nicolas Casaretto, Julian Garrec, Stellios Arseniyadis, Laurent El Kaïm
A copper-catalyzed borylation of allylic nitroalkanes is reported. The method, which exploits the high versatility of the nitroalkane precursors, tolerates a variety of functional groups and allows a straightforward access to diversely substituted al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43b6ddecbc8905ff99178850d8c9cace
https://doi.org/10.26434/chemrxiv-2023-mztk4
https://doi.org/10.26434/chemrxiv-2023-mztk4
Autor:
Laurent El Kaïm, Cristina Cheibas, Emilie Vieu, Nicolas Casaretto, Maxime Vitale, Laurence Grimaud
Publikováno v:
Synlett.
Ugi adducts involving malonic acid monoesters and dialkoxy-substituted aromatic aldehydes can undergo an oxidative dearomatization when treated with Mn(OAc)3 leading to the formation of fused cyclopropanes as observed in the Buchner reaction of diazo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::95d887e82bd65c818e7dcf1d8fc4d9b1
https://doi.org/10.1055/a-2005-5220
https://doi.org/10.1055/a-2005-5220
Passerini–Smiles Reaction of α‐Ketophosphonates: Platform for Phospha‐Brook/Smiles Embedded Cascades
Publikováno v:
Angewandte Chemie International Edition. 61
The Passerini-Smiles reactions of α-ketophosphonates with nitrophenols has been used as a platform to observe complex cascades involving multiple Smiles transfers coupled with phospha-Brook rearrangement. When using 4-nitrophenols a rare 1,3-Truce-S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ba70ed453f3d3bb47c32378bd26d64f
https://doi.org/10.1002/anie.202116249
https://doi.org/10.1002/anie.202116249
Publikováno v:
Molecules, Vol 16, Iss 11, Pp 9261-9273 (2011)
A short sequential synthesis of pyrrolidino- pyridines and pyrimidines illustrates the potential of combining Ugi-Smiles couplings with radical tin-free processes.
Externí odkaz:
https://doaj.org/article/df9f6a96575c4ca5b46fca4f2c81b2c5
Autor:
Elodie Martinand-Lurin, Aurélie Dos Santos, Emmanuelle Robineau, Pascal Retailleau, Philippe Dauban, Laurence Grimaud, Laurent El Kaïm
Publikováno v:
Molecules, Vol 21, Iss 9, p 1257 (2016)
Initial conditions disclosed for the Passerini-Smiles reaction are associated with a lack of efficiency that has prevented chemists from using it since its discovery. We wish to report herein our thorough study in the development of new experimental
Externí odkaz:
https://doaj.org/article/e2eab36eed59462f974414ef12cb3e59
Publikováno v:
Tetrahedron Letters
Tetrahedron Letters, Elsevier, 2021, 64, pp.152742. ⟨10.1016/j.tetlet.2020.152742⟩
Tetrahedron Letters, Elsevier, 2021, 64, pp.152742. ⟨10.1016/j.tetlet.2020.152742⟩
International audience; Herein, a synthesis of 2-phosphonodihydrofurans and 2-phosphonodihydropyrroles via 5-endo cyclization of O-and N-propargylated compounds is described. The reaction is promoted by potassium tert-butoxide and allows a fast acces
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9692bbaede6ff404af6800909bb54bfa
https://doi.org/10.1016/j.tetlet.2020.152742
https://doi.org/10.1016/j.tetlet.2020.152742
Autor:
Jieping Zhu, Laurent El Kaïm, Gian Cesare Tron, Rodolfo Lavilla, Luca Banfi, Andrea Basso, Valentina Cerulli, Giuseppe Guanti, Paulina Lecinska, Renata Riva, M. J. Arévalo, N. Kielland, C. Masdeu, M. Miguel, N. Isambert, R. Lavilla, Alevtina S. Medvedeva, Vladimir V. Novokshonov, Irina A. Novokshonova, Maria M. Demina, Tatyana V. Kon’kova, Yurii V. Shklyaev, Yulia S. Rozhkova, Tatiana S. Vshivkova, Olga G. Stryapunina, Vladimir A. Glushkov, Anastasia V. Kharitonova, Alexander S. Fisyuk, Aleksey Y. Mukanov, Nicolay V. Poendaev, Anton V. Gulevich, Valentine G. Nenajdenko, Maria N. Ivantsova, Maria I. Tokareva, Maxim A. Mironov, Vladimir S. Mokrushin, Tracey Pirali, Igor B. Rozentsveig, Aleksandr V. Popov, Galina G. Levkovskaya, Kirill A. Chernyshev, Leonid B. Krivdin, Yury V. Tomilov, Dmitry N. Platonov, Alexander Y. Rulev, Igor A. Ushakov, Alexandra Vorobyeva, Alexey Ilyin, Volodimir Kysil, Alexandre Ivachtchenko
Publikováno v:
MCR 2009 ISBN: 9781441972699
Multi-component reactions (MCRs) have now been well established as a powerful synthetic tool for creating molecular complexity and diversity and are undoubtedly well suited for the drug discovery program. Another potential that has probably received
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d2b70283beb8eebec16b565958173ef0
https://doi.org/10.1007/978-1-4419-7270-5_5
https://doi.org/10.1007/978-1-4419-7270-5_5
Publikováno v:
Tetrahedron Letters. 32:5321-5324
The reaction of isaxazol-5-ones derived from β-keto esters and hydroxylamine with sodium nitrite and ferrous sulphate in aqueous acetic acid affords the corresponding acetylenes in moderate to good yield.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::32f0f959ed1be7cd5db4499fd2e02635
https://doi.org/10.1016/s0040-4039(00)92375-x
https://doi.org/10.1016/s0040-4039(00)92375-x
Publikováno v:
Chemical Communications; Mar2008, Vol. 2008 Issue 11, p1350-1352, 3p