A genomic-augmented multivariate prognostic model for the survival of natural-killer/T-cell lymphoma patients from an international cohort.

Autor: Lim JQ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.; ONCO-ACP, Duke-NUS Medical School, Singapore., Huang D; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.; ONCO-ACP, Duke-NUS Medical School, Singapore., Chan JY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Laurensia Y; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Wong EKY; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Cheah DMZ; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Chia BKH; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Chuang WY; Department of Anatomic Pathology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan.; Chang Gung University, Taoyuan, Taiwan., Kuo MC; Chang Gung University, Taoyuan, Taiwan.; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Su YJ; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Cai QQ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Feng Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Rao H; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Feng LN; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Wei PP; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Chen JR; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Han BW; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Lin GW; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Cai J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Fang Y; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Tan J; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore., Hong H; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China.; Department of Medical Oncology, Sun Yat-sen University Cancer Center, Guangzhou, China., Liu Y; Guangdong Provincial People's Hospital, Guangdong, China.; Guangdong Academy of Medical Sciences, Guangdong, China., Zhang F; Guangdong Provincial People's Hospital, Guangdong, China.; Guangdong Academy of Medical Sciences, Guangdong, China., Li W; Guangdong Provincial People's Hospital, Guangdong, China.; Guangdong Academy of Medical Sciences, Guangdong, China., Poon MLM; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore., Ng SB; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore., Jeyasekharan A; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.; Department of Haematology-Oncology, National University Health System, Singapore City, Singapore., Ha JCH; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, Singapore City, Singapore., Khoo LP; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, Singapore City, Singapore., Chin ST; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, Singapore City, Singapore., Pang WL; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Kee R; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre Singapore, Singapore City, Singapore., Cheng CL; Department of Pathology, Singapore General Hospital, Singapore City, Singapore., Grigoropoulos NF; Department of Haematology, Singapore General Hospital, Singapore City, Singapore., Tang T; ONCO-ACP, Duke-NUS Medical School, Singapore., Tao M; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Farid M; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Puan KJ; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore City, Singapore., Xiong J; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine at Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Zhao WL; Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics,National Research Center for Translational Medicine at Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China., Khor CC; Genome Institute of Singapore, Singapore City, Singapore., Hwang W; Director's office, National Cancer Centre, Singapore City, Singapore., Kim WS; Division of Hematology-Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea., Campo E; Institut D'Investigacions Biomediques August Pi I Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Spain., Tan P; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.; Genome Institute of Singapore, Singapore City, Singapore.; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore City, Singapore., Teh BT; Laboratory of Cancer Epigenome, Division of Medical Sciences, National Cancer Centre Singapore, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore.; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore City, Singapore., Chng WJ; Department of Haematology-Oncology, National University Cancer Institute of Singapore, National University Health System, Singapore.; Cancer Science Institute of Singapore, National University of Singapore, Singapore City, Singapore., Rötzschke O; Singapore Immunology Network (SIgN), A*STAR (Agency for Science, Technology and Research), Singapore City, Singapore., Tousseyn T; Translational Cell and Tissue Research Lab, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium.; Department of Pathology, UZ Leuven, Leuven, Belgium., Huang HQ; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Rozen S; Programme in Cancer and Stem Cell Biology, Duke-NUS Medical School, Singapore City, Singapore.; Centre for Computational Biology, Duke-NUS Medical School, Singapore City, Singapore., Lim ST; Director's office, National Cancer Centre, Singapore City, Singapore.; Office of Education, Duke-NUS Medical School, Singapore City, Singapore., Shih LY; Chang Gung University, Taoyuan, Taiwan.; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan., Bei JX; State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China., Ong CK; Lymphoma Genomic Translational Research Laboratory, Cellular and Molecular Research, National Cancer Centre Singapore, Singapore.; Genome Institute of Singapore, Singapore City, Singapore.; Cancer and Stem Cell Biology, Duke-NUS Graduate Medical School, Singapore City, Singapore.

Publikováno v: American journal of hematology [Am J Hematol] 2022 Sep; Vol. 97 (9), pp. 1159-1169. Date of Electronic Publication: 2022 Jul 05.

No association between ECSIT germline mutations and hemophagocytic lymphohistiocytosis in natural killer/T-cell lymphoma.

Autor: Ong SY; Department of Haematology, Singapore General Hospital., Lim JQ; National Cancer Center, Singapore; Duke-NUS Medical School., Grigoropoulos N; Department of Haematology, Singapore General Hospital., Laurensia Y; National Cancer Center., Huang D; National Cancer Center, Singapore; Duke-NUS Medical School., Chia BKH; National Cancer Center., Zhe DCM; National Cancer Center., Saraf SA; Department of Pathology, Singapore General Hospital., Cheng CL; Department of Pathology, Singapore General Hospital., Chuang WY; Department of Pathology, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan., Kuo MC; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan., Su YJ; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan., Phipps C; Department of Haematology, Singapore General Hospital., Nagarajan C; Department of Haematology, Singapore General Hospital., Lee YS; Department of Haematology, Singapore General Hospital., Lung DTC; Department of Haematology, Singapore General Hospital., Shih LY; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, and Chang Gung University, Taoyuan., Goh YT; Department of Haematology, Singapore General Hospital., Lim ST; National Cancer Center, Singapore; Duke-NUS Medical School. lim.soon.thye@singhealth.com.sg., Ong CK; National Cancer Center, Singapore; Duke-NUS Medical School, Singapore; Genome Institute of Singapore, A*STAR. cmrock@nccs.com.sg.

Publikováno v: Haematologica [Haematologica] 2021 Jun 01; Vol. 106 (6), pp. 1737-1739. Date of Electronic Publication: 2021 Jun 01.

Antibody-Based Therapies for Peripheral T-Cell Lymphoma.

Autor: Shafagati, Nazila¹ (AUTHOR) nshafag1@jhu.edu, Paul, Suman¹ (AUTHOR), Rozati, Sima¹ (AUTHOR), Sterling, Cole H.¹ (AUTHOR) nshafag1@jhu.edu

Publikováno v: Cancers. Oct2024, Vol. 16 Issue 20, p3489. 22p.

Whole-genome sequencing reveals potent therapeutic strategy for monomorphic epitheliotropic intestinal T-cell lymphoma.

Autor: Huang D; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore.; Duke-NUS Medical School, Singapore., Lim JQ; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore.; Duke-NUS Medical School, Singapore., Cheah DMZ; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore., Kahliab KHBM; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore., Laurensia Y; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore., Pang JWL; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore., Wong EKY; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore., Chia BKH; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore., Goh J; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Zhang X; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Chan JY; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Chow EK; Cancer Science Institute of Singapore, National University of Singapore, Singapore., Tan SY; National University of Singapore Yong Loo Lin School of Medicine, Singapore., Lim ST; Duke-NUS Medical School, Singapore.; Division of Medical Oncology, National Cancer Centre Singapore, Singapore.; SingHealth Duke-NUS Blood Cancer Centre, Singapore; and., Ong CK; Lymphoma Genomic Translational Research Laboratory, Division of Medical Oncology, National Cancer Centre, Singapore.; Duke-NUS Medical School, Singapore.; Genome Institute of Singapore, Singapore.

Publikováno v: Blood advances [Blood Adv] 2020 Oct 13; Vol. 4 (19), pp. 4769-4774.

Genetic risk of extranodal natural killer T-cell lymphoma: a genome-wide association study in multiple populations.

Autor: Lin GW; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China., Xu C; Hematology Research Laboratory, Department of Hematology, West China Hospital, Sichuan University, Chengdu, China., Chen K; Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China., Huang HQ; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Chen J; Department of Hematology, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China., Song B; Department of Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, China., Chan JKC; Department of Pathology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region, China., Li W; Department of Lymphoma, Guangdong Academy of Medical Sciences, Guangzhou, China., Liu W; Department of Pathology, West China Hospital, Sichuan University, Chengdu, China., Shih LY; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan; Chang Gung University, Taoyuan., Chuang WY; Department of Pathology, Chang Gung Memorial Hospital and Chang Gung University, Taoyuan., Kim WS; Division of Hematology and Oncology, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea., Tan W; Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Peng RJ; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Laurensia Y; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Cheah DMZ; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Huang D; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore., Cheng CL; Department of Pathology, Singapore General Hospital, Singapore., Su YJ; Division of Hematology-Oncology, Chang Gung Memorial Hospital at Linkou, Taoyuan., Tan SY; Department of Pathology, Guangdong Academy of Medical Sciences, Guangzhou, China; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Pathology, National University Hospital, National University Health System, Singapore; Institute of Molecular and Cell Biology, A*STAR, Singapore; Department of Pathology, University of Malaya, Kuala Lumpur, Malaysia., Ng SB; Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cancer Science Institute of Singapore, National University of Singapore, Singapore; Department of Pathology, National University Hospital, National University Health System, Singapore., Tang TPL; Division of Medical Oncology, National Cancer Centre Singapore, Singapore., Han K; Department of Nanobiomedical Science, BK21 PLUS NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan, South Korea., Wang VY; Faculty of Health Sciences, University of Macau, Macau Special Administrative Region, China., Jia WH; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Pei Z; Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China., Li YJ; Department of Lymphoma and Hematology, Hunan Cancer Hospital, Changsha, China; The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China., Gao S; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Shi Y; The Affiliated Hospital of Qingdao University & the Biomedical Sciences Institute of Qingdao University, Qingdao Branch of SJTU Bio-X Institutes, Qingdao University, Qingdao, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China., Hu Z; Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing, China., Zhang F; Shandong Provincial Institute of Dermatology and Venereology, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China., Zhang B; Department of Epidemiology and Biostatistics, First Affiliated Hospital, Army Medical University, Chongqing, China., Zeng YX; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China., Shen H; Department of Epidemiology and Biostatistics, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University, Nanjing, China., He L; The Affiliated Hospital of Qingdao University & the Biomedical Sciences Institute of Qingdao University, Qingdao Branch of SJTU Bio-X Institutes, Qingdao University, Qingdao, China; Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), the Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University, Shanghai, China; Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, China., Ong CK; Lymphoma Genomic Translational Research Laboratory, Division of Cellular and Molecular Research, National Cancer Centre Singapore, Singapore; Genome Institute of Singapore, Singapore; Duke-NUS Medical School, Singapore., Lim ST; Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Duke-NUS Medical School, Singapore; SingHealth Duke-NUS Blood Cancer Centre, Singapore., Chanock S; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Kwong YL; Department of Medicine, Queen Mary Hospital, Hong Kong Special Administrative Region, China., Lin D; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Department of Etiology and Carcinogenesis, National Cancer Center/National Clinical Research Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China., Rothman N; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Khor CC; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Genome Institute of Singapore, Singapore; Singapore Eye Research Institute, Singapore., Lan Q; Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA., Bei JX; Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, China; Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China; Division of Medical Oncology, National Cancer Centre Singapore, Singapore; Center for Precision Medicine, Sun Yat-sen University, Guangzhou, China. Electronic address: beijx@sysucc.org.cn.

Publikováno v: The Lancet. Oncology [Lancet Oncol] 2020 Feb; Vol. 21 (2), pp. 306-316. Date of Electronic Publication: 2019 Dec 23.