Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Laurens P Kil"'
Autor:
Laurens P Kil, Joost Vaneman, Joan E M van der Lubbe, Dominika Czapska-Casey, Jeroen T B M Tolboom, Ramon Roozendaal, Roland C Zahn, Harmjan Kuipers, Laura Solforosi
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225063 (2019)
Correlates of protection (CoP) are invaluable for iterative vaccine design studies, especially in pursuit of complex vaccines such as a universal influenza vaccine (UFV) where a single antigen is optimized to elicit broad protection against many vira
Externí odkaz:
https://doaj.org/article/2c43560738414ddbbd753da589cbbf12
Autor:
Janine Schuurman, Martine E.D. Chamuleau, Paul W. H. I. Parren, Jeroen van den Brakel, Ronald P. Taylor, Marije B. Overdijk, Hilma J. van der Horst, Simone C. Oostindie, Hendrik J. Rademaker, Frank J. Beurskens, Juliette van den Noort, Berris van Kessel, Esther C.W. Breij, Margaret A. Lindorfer, Kristin Strumane, Laurens P. Kil, Tuna Mutis, Edward Van Den Brink
Publikováno v:
Blood Cancer Journal, 10(3). NATURE PUBLISHING GROUP
Oostindie, S C, van der Horst, H J, Kil, L P, Strumane, K, Overdijk, M B, van den Brink, E N, van den Brakel, J H N, Rademaker, H J, van Kessel, B, van den Noort, J, Chamuleau, M E D, Mutis, T, Lindorfer, M A, Taylor, R P, Schuurman, J, Parren, P W H I, Beurskens, F J & Breij, E C W 2020, ' DuoHexaBody-CD37 ®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies ', Blood cancer journal, vol. 10, no. 3, 30 . https://doi.org/10.1038/s41408-020-0292-7
Blood cancer journal, 10(3):30. Nature Publishing Group
Blood Cancer Journal, Vol 10, Iss 3, Pp 1-13 (2020)
Oostindie, S C, van der Horst, H J, Kil, L P, Strumane, K, Overdijk, M B, van den Brink, E N, van den Brakel, J H N, Rademaker, H J, van Kessel, B, van den Noort, J, Chamuleau, M E D, Mutis, T, Lindorfer, M A, Taylor, R P, Schuurman, J, Parren, P W H I, Beurskens, F J & Breij, E C W 2020, ' DuoHexaBody-CD37 ®, a novel biparatopic CD37 antibody with enhanced Fc-mediated hexamerization as a potential therapy for B-cell malignancies ', Blood cancer journal, vol. 10, no. 3, 30 . https://doi.org/10.1038/s41408-020-0292-7
Blood cancer journal, 10(3):30. Nature Publishing Group
Blood Cancer Journal, Vol 10, Iss 3, Pp 1-13 (2020)
Tetraspanin CD37 has recently received renewed interest as a therapeutic target for B-cell malignancies. Although complement-dependent cytotoxicity (CDC) is a powerful Fc-mediated effector function for killing hematological cancer cells, CD37-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b0286279d1b9ed42c80861ce3d6a052
https://www.nature.com/articles/s41408-020-0292-7
https://www.nature.com/articles/s41408-020-0292-7
Autor:
Odilia B. J. Corneth, Jasper Rip, Laurens P. Kil, Wilfried Ellmeier, Rudi W. Hendriks, Marjolein J. W. de Bruijn, Esmee K. van der Ploeg, Van T. B. Ta, Lars W. van Greuningen, Anton W. Langerak, Guus F. Rimmelzwaan
Publikováno v:
Journal of Immunology, 198(8), 3058-3068. American Association of Immunologists
The Tec tyrosine kinase is expressed in many cell types, including hematopoietic cells, and is a member of the Tec kinase family that also includes Btk. Although the role of Btk in B cells has been extensively studied, the role of Tec kinase in B cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de3d0741cecac214d342085552c509a6
https://doi.org/10.4049/jimmunol.1601285
https://doi.org/10.4049/jimmunol.1601285
Autor:
Jeroen van den Brakel, Ida H. Hiemstra, David Satijn, Sanne van Dooremalen, Maarten L. Janmaat, Esther C.W. Breij, Peter Boross, Tahamtan Ahmadi, Bart De Goeij, Laurens P. Kil, Sieto Bosgra, Grietje Andringa, Wessel ten Hagen, A. Kate Sasser
Publikováno v:
Blood. 136:19-20
HexaBody®-CD38 (GEN3014) is a next-generation CD38-specific IgG1 molecule with a hexamerization-enhancing mutation that leads to highly efficient induction of complement-dependent cytotoxicity (CDC) upon binding to CD38 positive tumor cells. HexaBod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a52b2b9f5088c09d60608426f2374f79
https://doi.org/10.1182/blood-2020-140313
https://doi.org/10.1182/blood-2020-140313
Autor:
Grietje Andringa, Andreas Lingnau, Laurens P. Kil, Niels W.C.J. van de Donk, David Satijn, Tuna Mutis, A. Kate Sasser, Kristine A. Frerichs, Andreas Freidig, Tahamtan Ahmadi, Bart De Goeij, Berris van Kessel, Esther C.W. Breij, Maarten L. Janmaat
Publikováno v:
De Goeij, B E C G, Janmaat, M L, Andringa, G, Kil, L, Van Kessel, B, Frerichs, K A, Lingnau, A, Freidig, A, Mutis, T, Sasser, A K, Breij, E C W, Van de Donk, N W C J, Ahmadi, T & Satijn, D 2019, ' Hexabody-CD38, a Novel CD38 Antibody with a Hexamerization Enhancing Mutation, Demonstrates Enhanced Complement-Dependent Cytotoxicity and Shows Potent Anti-Tumor Activity in Preclinical Models of Hematological Malignancies ', Blood, vol. 134 . https://doi.org/10.1182/blood-2019-125788
Blood, 134. American Society of Hematology
Blood, 134. American Society of Hematology
HexaBody-CD38 (GEN3014) is a novel, hexamerization-enhanced human IgG1 targeting CD38 with superior complement dependent cytotoxicity (CDC) activity, in addition to other effector mechanisms. HexaBody-CD38 carries the E430G mutation and binds a diffe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dc52409d185e513ba4070482b7ad83c
https://research.vumc.nl/en/publications/5eca2ce7-5698-4119-8c31-e64e1ace7b9d
https://research.vumc.nl/en/publications/5eca2ce7-5698-4119-8c31-e64e1ace7b9d
Autor:
Simone C, Oostindie, Hilma J, van der Horst, Laurens P, Kil, Kristin, Strumane, Marije B, Overdijk, Edward N, van den Brink, Jeroen H N, van den Brakel, Hendrik J, Rademaker, Berris, van Kessel, Juliette, van den Noort, Martine E D, Chamuleau, Tuna, Mutis, Margaret A, Lindorfer, Ronald P, Taylor, Janine, Schuurman, Paul W H I, Parren, Frank J, Beurskens, Esther C W, Breij
Publikováno v:
Blood Cancer Journal
Tetraspanin CD37 has recently received renewed interest as a therapeutic target for B-cell malignancies. Although complement-dependent cytotoxicity (CDC) is a powerful Fc-mediated effector function for killing hematological cancer cells, CD37-specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4d7a337366475d5cefbea9c3d4988659
https://pubmed.ncbi.nlm.nih.gov/32341336
https://pubmed.ncbi.nlm.nih.gov/32341336
Autor:
Laura Solforosi, Dominika Czapska-Casey, Harmjan Kuipers, Laurens P Kil, Ramon Roozendaal, Joost Vaneman, Jeroen Tolboom, Joan E. M. van der Lubbe, Roland Zahn
Publikováno v:
PLoS ONE, Vol 14, Iss 11, p e0225063 (2019)
PLoS ONE
PLoS ONE
Correlates of protection (CoP) are invaluable for iterative vaccine design studies, especially in pursuit of complex vaccines such as a universal influenza vaccine (UFV) where a single antigen is optimized to elicit broad protection against many vira
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce1b22fc9bf1a534eaa3dcfb0a08a1fa
https://doaj.org/article/2c43560738414ddbbd753da589cbbf12
https://doaj.org/article/2c43560738414ddbbd753da589cbbf12
Autor:
Laurens P. Kil, Rudi W. Hendriks, Marjolein J. W. de Bruijn, Jasper Rip, Patrick S. Asmawidjaja, Odilia B. J. Corneth
Publikováno v:
Journal of Immunology, 197(1), 58-67. American Association of Immunologists
Upon BCR stimulation, naive B cells increase protein levels of the key downstream signaling molecule Bruton’s tyrosine kinase (BTK). Transgenic CD19-hBtk mice with B cell–specific BTK overexpression show spontaneous germinal center formation, ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1572c9a7981a66f00425aaf1d99ada07
https://doi.org/10.4049/jimmunol.1600208
https://doi.org/10.4049/jimmunol.1600208
Autor:
Tuna Mutis, Paul W. H. I. Parren, Andreas Lingnau, Marije B. Overdijk, Ronald P. Taylor, Martine E.D. Chamuleau, Frank J. Beurskens, Marcel Brandhorst, A. Kate Sasser, Janine Schuurman, Margaret A. Lindorfer, Kristin Strumane, Simone C. Oostindie, Jeroen van den Brakel, Berris van Kessel, Esther C.W. Breij, Hilma J. van der Horst, Laurens P. Kil
Publikováno v:
Cancer Research. 80:4544-4544
CD37 is a tetraspanin expressed on mature B cells where it orchestrates plasma membrane organization, receptor signaling, cell migration and adhesion. As CD37 is abundantly expressed on many mature B cell-derived malignancies, it represents an attrac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e15344396187f92390a98999dcba731c
https://doi.org/10.1158/1538-7445.am2020-4544
https://doi.org/10.1158/1538-7445.am2020-4544
Autor:
Rudi W. Hendriks, Patrick S. Asmawidjaja, Odilia B. J. Corneth, Marjolein J. W. de Bruijn, Laurens P. Kil, Erik Lubberts, Pieter Fokko van Loo, Arndt Krause
Publikováno v:
Journal of Autoimmunity, 57, 30-41. Academic Press
While surrogate light chain (SLC) expression is normally terminated in differentiating pre-B cells, co-expression of SLC and conventional light chains has been reported in a small population of autoreactive peripheral human B cells that accumulate in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbda61c4a0d6bed2807b81abc4786fe3
https://pure.eur.nl/en/publications/c5427f8f-4bef-4bcd-95fb-375eea8f2b91
https://pure.eur.nl/en/publications/c5427f8f-4bef-4bcd-95fb-375eea8f2b91