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pro vyhledávání: '"Laurens Leys"'
Autor:
Gust Nuytten, Susan Ríos Revatta, Pieter-Jan Van Bockstal, Ashish Kumar, Joris Lammens, Laurens Leys, Brecht Vanbillemont, Jos Corver, Chris Vervaet, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2076 (2021)
During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis. The aqueous drug formulation subsequently spreads over the inner vial wall, while a cold gas f
Externí odkaz:
https://doaj.org/article/8426039a85ab42959ba7b16b7114420a
Autor:
Laurens Leys, Gust Nuytten, Joris Lammens, Pieter-Jan Van Bockstal, Jos Corver, Chris Vervaet, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2168 (2021)
The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the implementatio
Externí odkaz:
https://doaj.org/article/6fad6831d9274b0eae4b56f08186be39
Autor:
Joris Lammens, Niloofar Moazami Goudarzi, Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Chris Vervaet, Matthieu N. Boone, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2126 (2021)
Spin freeze-drying, as a part of a continuous freeze-drying technology, is associated with a much higher drying rate and a higher level of process control in comparison with batch freeze-drying. However, the impact of the spin freezing rate on the dr
Externí odkaz:
https://doaj.org/article/7656bbca8fb642298bc91698c967d840
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 181 (2020)
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are t
Externí odkaz:
https://doaj.org/article/b18345b20fdf456e8e4661b9b32b8bd9
Publikováno v:
International Journal of Pharmaceutics. 641:123062
Autor:
T. De Beer, Laurens Leys, Jos Corver, P.J. Van Bockstal, G. Nuytten, Chris Vervaet, Brecht Vanbillemont, Joris Lammens
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 157:97-107
An innovative continuous spin-freeze-drying technology for unit doses was recently developed. For this technology, a mechanistic primary drying model was developed allowing the calculation of the optimal dynamic drying trajectory for spin-frozen form
Publikováno v:
Pharmaceutics
Volume 12
Issue 2
Pharmaceutics, Vol 12, Iss 2, p 181 (2020)
PHARMACEUTICS
Volume 12
Issue 2
Pharmaceutics, Vol 12, Iss 2, p 181 (2020)
PHARMACEUTICS
The standard operation of a batch freeze-dryer is protocol driven. All freeze-drying phases (i.e., freezing, primary and secondary drying) are programmed sequentially at fixed time points and within each phase critical process parameters (CPPs) are t