Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Laurene S Cheung"'
Autor:
Drew M Pardoll, Evan Lipson, John-William Sidhom, Karim Boudadi, Robert Anders, Dung T Le, Luis A Diaz, Nicolas Llosa, Janis Taube, Lingling Chen, Teniola F Oke, Christian F Meyer, Laurene S Cheung, Thomas B Schaffer, Jillian T Ngo, John McMahon Gross, Holly Kemberling
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Undifferentiated pleomorphic sarcoma (UPS), an aggressive soft-tissue sarcoma of adults, has been characterized by low tumor mutational burden (TMB) and high copy number alterations. Clinical trials of programmed death-1 (PD-1) blockade in UPS have r
Externí odkaz:
https://doaj.org/article/49dd5e69ccc04ef2b5cc0e561cbddcbd
Autor:
Amit J Sabnis, Laurene S Cheung, Monique Dail, Hio Chung Kang, Marianne Santaguida, Michelle L Hermiston, Emmanuelle Passegué, Kevin Shannon, Benjamin S Braun
Publikováno v:
PLoS Biology, Vol 7, Iss 3, p e59 (2009)
How oncogenes modulate the self-renewal properties of cancer-initiating cells is incompletely understood. Activating KRAS and NRAS mutations are among the most common oncogenic lesions detected in human cancer, and occur in myeloproliferative disorde
Externí odkaz:
https://doaj.org/article/55fb03daa2bc4376b9d210391fe4c84f
Autor:
Arbor G. Dykema, Boyang Zhang, Bezawit A. Woldemeskel, Caroline C. Garliss, Rufiaat Rashid, Timothy Westlake, Li Zhang, Jiajia Zhang, Laurene S. Cheung, Justina X. Caushi, Drew M. Pardoll, Andrea L. Cox, Hongkai Ji, Kellie N. Smith, Joel N. Blankson
Publikováno v:
EBioMedicine, Vol 80, Iss , Pp 104048- (2022)
Summary: Background: COVID-19 mRNA vaccines elicit strong T and B cell responses to the SARS-CoV-2 spike glycoprotein in both SARS-CoV-2 naïve and experienced patients. However, it is unknown whether the post-vaccine CD4+ T cell responses seen in pa
Externí odkaz:
https://doaj.org/article/a44b594af9e6401aae4458d7a54a5518
Autor:
Arbor G. Dykema, Jiajia Zhang, Boyang Zhang, Laurene S. Cheung, Zhen Zeng, Christopher M. Cherry, Taibo Li, Justina X. Caushi, Marni Nishimoto, Sydney Connor, Zhicheng Ji, Andrew J. Munoz, Wenpin Hou, Wentao Zhan, Dipika Singh, Rufiaat Rashid, Marisa Mitchell-Flack, Sadhana Bom, Ada Tam, Nick Ionta, Yi Wang, Camille A. Sawosik, Lauren E. Tirado, Luke M. Tomasovic, Derek VanDyke, Jamie B. Spangler, Valsamo Anagnostou, Stephen Yang, Jonathan Spicer, Roni Rayes, Janis Taube, Julie R. Brahmer, Patrick M. Forde, Srinivasan Yegnasubramanian, Hongkai Ji, Drew M. Pardoll, Kellie N. Smith
Regulatory T cells (Treg) are conventionally viewed to suppress endogenous and therapyinduced anti-tumor immunity; however, their role in modulating responses to immune checkpoint blockade (ICB) is unclear. In this study, we integrated single-cell RN
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ce42b39bf2f7a64cbf23b41e33e0bda2
https://doi.org/10.1101/2022.12.13.520329
https://doi.org/10.1101/2022.12.13.520329
Autor:
Dipali Sharma, John R. Murphy, Jessica Shen, Sadiya Parveen, Sumit Siddharth, Laurene S. Cheung, William R. Bishai, Alok Kumar
Publikováno v:
Molecular Oncology, Vol 15, Iss 5, Pp 1330-1344 (2021)
Molecular Oncology
Molecular Oncology
In many solid tumors including triple‐negative breast cancer (TNBC), upregulation of the interleukin‐4 receptor (IL‐4R) has been shown to promote cancer cell proliferation, apoptotic resistance, metastatic potential, and a Th2 response in the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5973dad70715196b76b3845aeaa4fede
https://doi.org/10.1002/1878-0261.12938
https://doi.org/10.1002/1878-0261.12938
Autor:
Derek VanDyke, Marcos Iglesias, Jakub Tomala, Arabella Young, Jennifer Smith, Joseph A. Perry, Edward Gebara, Amy R. Cross, Laurene S. Cheung, Arbor G. Dykema, Brian T. Orcutt-Jahns, Tereza Henclová, Jaroslav Golias, Jared Balolong, Luke M. Tomasovic, David Funda, Aaron S. Meyer, Drew M. Pardoll, Joanna Hester, Fadi Issa, Christopher A. Hunter, Mark S. Anderson, Jeffrey A. Bluestone, Giorgio Raimondi, Jamie B Spangler
Publikováno v:
Cell reports. 41(3)
SummaryLow dose human interleukin-2 (hIL-2) treatment is used clinically to treat autoimmune disorders due to the cytokine’s preferential expansion of immunosuppressive regulatory T cells (TRegs). However, high toxicity, short serum half-life, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e735d94cba921e4f4a8a5c9a871324f2
https://pubmed.ncbi.nlm.nih.gov/36261022
https://pubmed.ncbi.nlm.nih.gov/36261022
Autor:
Arbor G. Dykema, Boyang Zhang, Bezawit A. Woldemeskel, Caroline C. Garliss, Rufiaat Rashid, Timothy Westlake, Li Zhang, Jiajia Zhang, Laurene S. Cheung, Justina X. Caushi, Drew M. Pardoll, Andrea L. Cox, Hongkai Ji, Kellie N. Smith, Joel N. Blankson
Publikováno v:
EBioMedicine. 80
COVID-19 mRNA vaccines elicit strong T and B cell responses to the SARS-CoV-2 spike glycoprotein in both SARS-CoV-2 naïve and experienced patients. However, it is unknown whether the post-vaccine CD4+ T cell responses seen in patients with a history
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07a9edb38bba61dca5584ddc5e8e74bb
https://pubmed.ncbi.nlm.nih.gov/35533495
https://pubmed.ncbi.nlm.nih.gov/35533495
Autor:
Teniola Oke, Thomas B. Schaffer, Evan J. Lipson, Dung T. Le, Christian F. Meyer, Lingling Chen, John Mc Mahon Gross, Laurene S. Cheung, Jillian T. Ngo, Nicolas J. Llosa, Janis M. Taube, Holly Kemberling, Karim Boudadi, John-William Sidhom, Robert A. Anders, Drew M. Pardoll, Luis A. Diaz
Publikováno v:
Journal for Immunotherapy of Cancer
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 6 (2021)
Undifferentiated pleomorphic sarcoma (UPS), an aggressive soft-tissue sarcoma of adults, has been characterized by low tumor mutational burden (TMB) and high copy number alterations. Clinical trials of programmed death-1 (PD-1) blockade in UPS have r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ef2c14d93b771f05b79e452ed72cefd
https://pubmed.ncbi.nlm.nih.gov/34103354
https://pubmed.ncbi.nlm.nih.gov/34103354
Autor:
Drew M. Pardoll, Bezawit A. Woldemeskel, Franco R. D'Alessio, Hongkai Ji, Emily Han-Chung Hsiue, Kellie N. Smith, Justina X. Caushi, Jiajia Zhang, Shibin Zhou, Jonathan D. Powell, Alvaro A. Ordonez, Rufiaat Rashid, Arbor G. Dykema, Elizabeth A. Thompson, Joel N. Blankson, Boyang Zhang, Caroline C. Garliss, Dilshad Choudhury, Sadhana Bom, Sampriti Thapa, Laurene S. Cheung, Dipika Singh, Andrea L. Cox, Andrew Pekosz, Abena K. Kwaa, Katherine Cascino, Srinivasan Yegnasubramanian, Luis Aparicio
Publikováno v:
J Clin Invest
BACKGROUND: Recent studies have reported T cell immunity to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in unexposed donors, possibly due to crossrecognition by T cells specific for common cold coronaviruses (CCCs). True T cell c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a61350755e86a6f96061d7c5e47ea1c9
https://doi.org/10.1172/jci146922
https://doi.org/10.1172/jci146922
Autor:
Alyza M. Skaist, Patrick M. Forde, Rulin Wang, Jiajia Zhang, Malcolm V. Brock, Zineb Belcaid, Haidan Guo, Victor E. Velculescu, Joshua E. Reuss, Matthew J. Bott, Matthew D. Hellmann, Sarah J. Wheelan, Boyang Zhang, Kristen A. Marrone, Peter B. Illei, Ajay Vaghasia, Richard L. Blosser, Sune Justesen, Bert Vogelstein, Jamie E. Chaft, Sampriti Thapa, Errol L. Bush, Srinivasan Yegnasubramanian, Janis M. Taube, Julie R. Brahmer, Tricia R. Cottrell, Luis Aparicio, Jennifer Meyers, Kornel E. Schuebel, Hok Yee Chan, Taha Merghoub, Zhicheng Ji, Wenpin Hou, David R. Jones, Margueritta El Asmar, Bernard J. Park, Jarushka Naidoo, Kellie N. Smith, Jinny Ha, Kenneth W. Kinzler, Ada Tam, Dipika Singh, Brian J. Mog, Justina X. Caushi, Shibin Zhou, Valsamo Anagnostou, Hongkai Ji, Emily Han-Chung Hsiue, Mara Lanis, Poromendro Burman, Begum Choudhury, Drew M. Pardoll, Arbor G. Dykema, Anuj Gupta, Laurene S. Cheung
Publikováno v:
Nature
PD-1 blockade unleashes CD8 T cells1, including those specific for mutation-associated neoantigens (MANA), but factors in the tumour microenvironment can inhibit these T cell responses. Single-cell transcriptomics have revealed global T cell dysfunct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0645be637b0cd113a8d3e9f86fc9d9bf
https://pubmed.ncbi.nlm.nih.gov/34608287
https://pubmed.ncbi.nlm.nih.gov/34608287