Connexin36 and pancreatic β-cell functions

Autor: Philippe Klee, Rachel Nlend Nlend, Laurence Zulianello, Anne Charollais, José Antonio Cancela, Laetitia Michon, Sabine Bavamian, Eric Charpantier, Nathalie Boucard, Paolo Meda, Dorothée Caille, Manon Peyrou, Céline Populaire

Publikováno v: Archives of Physiology and Biochemistry. 112:74-81

Most cell types are functionally coupled by connexin (Cx) channels, i.e. exchange cytoplasmic ions and small metabolites through gap junction domains of their membrane. This form of direct cell-to-cell communication occurs in all existing animals, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c1562625fb43507d8639dae548d3fc
https://doi.org/10.1080/13813450600712019

Novel mechanisms in the immunopathogenesis of leprosy nerve damage: The role of Schwann cells, T cells andMycobacterium leprae

Autor: Laurence Zulianello, Tjitske de Boer, Eric Spierings, Tom H. M. Ottenhoff

Publikováno v: Immunology & Cell Biology. 78:349-355

The major complication of reversal (or type 1) reactions in leprosy is peripheral nerve damage. The pathogenesis of nerve damage remains largely unresolved. In situ analyses suggest an important role for type 1 T cells. Mycobacterium leprae is known

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ad718251510fc311b49f2ddef8afac
https://doi.org/10.1046/j.1440-1711.2000.00939.x

Cx36 makes channels coupling human pancreatic β-cells, and correlates with insulin expression

Autor: Benoit R. Gauthier, Laurence Zulianello, Eric Charpantier, Thierry Berney, Paolo Meda, Dorothée Caille, Piero Marchetti, Ben N G Giepmans, Anne Charollais, Vincenzo Cirulli, Véronique Serre-Beinier, Giuseppe R. Diaferia, Shaoping Deng, Domenico Bosco, Leo Buhler, Roberto Lupi

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Human molecular genetics, Vol. 18, No 3 (2009) pp. 428-39
Human Molecular Genetics
Human Molecular Genetics; Vol 18
Human Molecular Genetics, 18(3), 428-439. Oxford University Press

Previous studies have documented that the insulin-producing beta-cells of laboratory rodents are coupled by gap junction channels made solely of the connexin36 (Cx36) protein, and have shown that loss of this protein desynchronizes beta-cells, leadin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0f5c1c19c3bdd8966ff8381f2bc08ff
http://hdl.handle.net/10261/270659

Involvement of gap junctional communication in secretion

Autor: Sabine Bavamian, Laurence Zulianello, Laetitia Michon, Nathalie Boucard, Manon Peyrou, Lorraine Bischoff, Céline Populaire, José Antonio Cancela, Dorothée Caille, Eric Charpantier, Anne Charollais, Paolo Meda, Philippe Klee, Rachel Nlend Nlend

Publikováno v: Biochimica et biophysica acta. 1719(1-2)

Glands were the first type of tissues in which the permissive role of gap junctions in the cell-to-cell transfer of membrane-impermeant molecules was shown. During the 40 years that have followed this seminal finding, gap junctions have been document

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5a1a2b79ecd5f316b043eb1bb75652f
https://pubmed.ncbi.nlm.nih.gov/16359942

Dominant-negative inhibition of prion formation diminished by deletion mutagenesis of the prion protein

Autor: Laurence Zulianello, Stanley B. Prusiner, Susanne Erpel, Dong Han, Michael J. Scott, Frederick Cohen, Kiyotoshi Kaneko

Publikováno v: Journal of virology. 74(9)

The prion diseases are a group of neurodegenerative disorders that include kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler-Scheinker disease, and fatal insomnia in humans, scrapie in sheep, and bovine spongiform encephalopathy in cattle.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::320dad6f0b9363fc1cd7d51d67b14ce0
https://pubmed.ncbi.nlm.nih.gov/10756050