Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

Autor: Manon Boulet, Guerric Gilbert, Yoan Renaud, Martina Schmidt-Dengler, Emilie Plantié, Romane Bertrand, Xinsheng Nan, Tomasz Jurkowski, Mark Helm, Laurence Vandel, Lucas Waltzer

Publikováno v: eLife, Vol 12 (2023)

N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in Drosophila, for which the erasure of this epigenetic mark has been ascribed to the ten-eleven translocation (TET) enzyme. Here, we re-evaluated 6mA presenc

Externí odkaz: https://doaj.org/article/eebc17b941504cb9bf6392b11a80f6f0

Prmt5 promotes vascular morphogenesis independently of its methyltransferase activity.

Autor: Aurélie Quillien, Guerric Gilbert, Manon Boulet, Séverine Ethuin, Lucas Waltzer, Laurence Vandel

Publikováno v: PLoS Genetics, Vol 17, Iss 6, p e1009641 (2021)

During development, the vertebrate vasculature undergoes major growth and remodeling. While the transcriptional cascade underlying blood vessel formation starts to be better characterized, little is known concerning the role and mode of action of epi

Externí odkaz: https://doaj.org/article/386d1f8654b140748e71fd8ccd1799d6

Probing small ribosomal subunit RNA helix 45 acetylation across eukaryotic evolution

Autor: Marie-line Bortolin-Cavaillé, Aurélie Quillien, Patrick Blader, Laurence Vandel, Sunny Sharma, Célia Plisson-Chastang, Justin M. Thomas, Jordan L. Meier, Schraga Schwartz, Aldema Sas-Chen, Jérôme Cavaillé, Supuni Thalalla Gamage, Denis L. J. Lafontaine

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2022, 50, pp.6284-6299. ⟨10.1093/nar/gkac404⟩

NAT10 is an essential enzyme that catalyzes the formation of N4-acetylcytidine (ac4C) in eukaryotic transfer RNA (tRNA) and 18S ribosomal RNA (rRNA). Recent studies in human cells suggested that rRNA acetylation is dependent on SNORD13, a non-canonic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0558660df973337eac429792854c63b
https://pubmed.ncbi.nlm.nih.gov/35648437

Characterization of the Drosophila adult hematopoietic system reveals a rare cell population with differentiation and proliferation potential

Autor: Laurence Vandel, Yoan Renaud, Billel Benmimoun, Lucas Waltzer, Manon Boulet, François Lapraz

While many studies have described Drosophila embryonic and larval blood cells, the hematopoietic system of the imago remains poorly characterized and conflicting data have been published concerning adult hematopoiesis. Using a combination of blood ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::52f48d404b9587edcb7491828d9aff8e
https://doi.org/10.1101/2021.07.06.451161

From Drosophila Blood Cells to Human Leukemia

Autor: Marion Miller, Manon Boulet, Lucas Waltzer, Laurence Vandel

Publikováno v: Advances in Experimental Medicine and Biology
Advances in Experimental Medicine and Biology, Kluwer, 1970, pp.195-214. ⟨10.1007/978-981-13-0529-0_11⟩
From Drosophila Blood Cells to Human Leukemia
From Drosophila Blood Cells to Human Leukemia, pp.195-214, 2018
Advances in Experimental Medicine and Biology ISBN: 9789811305283

International audience; The hematopoietic system plays a critical role in establishing the proper response against invading pathogens or in removing cancerous cells. Furthermore, deregulations of the hematopoietic differentiation program are at the o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac3f82f44f0e9a93c65fc76973cb8ab7
https://pubmed.ncbi.nlm.nih.gov/29951821