Type I Collagen Aging Increases Expression and Activation of EGFR and Induces Resistance to Erlotinib in Lung Carcinoma in 3D Matrix Model

Autor: Thomas Sarazin, Guillaume Collin, Emilie Buache, Laurence Van Gulick, Céline Charpentier, Christine Terryn, Hamid Morjani, Charles Saby

Publikováno v: Frontiers in Oncology, Vol 10 (2020)

Type I collagen is the major structural component of lung stroma. Because of its long half-life, type I collagen undergoes post-translational modifications such as glycation during aging process. These modifications have been shown to impact the stru

Externí odkaz: https://doaj.org/article/a94240fca5bd4925bda21789b5ecdd5a

An integrated approach to investigate age-related modifications of morphological, mechanical and structural properties of type I collagen

Autor: Charles Saby, Anaïs Okwieka, Hamid Morjani, Stéphane Jaisson, Emilie Dervin, Laurence Van Gulick, Philippe Gillery, Abdelilah Beljebbar

Publikováno v: Acta Biomaterialia. 137:64-78

The main propose of this study is to characterize the impact of chronological aging on mechanical, structural, biochemical, and morphological properties of type I collagen. We have developed an original approach combining a stress-strain measurement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9385c743400cf4d4af3b73543ffeaaa7
https://doi.org/10.1016/j.actbio.2021.10.020

Investigation of squalene-doxorubicin distribution and interactions within single cancer cell using Raman microspectroscopy

Autor: Hamid Morjani, Abdelilah Beljebbar, Almar Al Assaad, Patrick Couvreur, Andrei Maksimenko, Maité Callewaert, Hassan Rammal, Didier Desmaële, Laurence Van Gulick, Barbara Stella, Simona Mura, Franco Dosio

Publikováno v: Nanomedicine: Nanotechnology, Biology and Medicine
Nanomedicine: Nanotechnology, Biology and Medicine, Elsevier, 2021, 35, pp.102404. ⟨10.1016/j.nano.2021.102404⟩

International audience; Intracellular distribution of doxorubicin (DOX) and its squalenoylated (SQ-DOX) nanoparticles (NPs) form in murine lung carcinoma M109 and human breast carcinoma MDA-MB-231 cells was investigated by Raman microspectroscopy. Ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::445a8a47358238ad7550dbd266033e15
https://doi.org/10.1016/j.nano.2021.102404

Original association of ion transporters mediates the ECM-induced breast cancer cell survival: Kv10.1-Orai1-SPCA2 partnership

Autor: Marta Peretti, Alban Girault, Marie-Pierre Mabille, Laurence Van Gulick, Halima Ouadid-Ahidouch, Mehdi Badaoui, Hamid Morjani, Henri Sevestre, Riad Tebbakha

Publikováno v: Scientific Reports
Scientific Reports, 2019, 9 (1), pp.1175. ⟨10.1038/s41598-018-37602-7⟩
Scientific Reports, Nature Publishing Group, 2019, 9 (1), pp.1175. ⟨10.1038/s41598-018-37602-7⟩
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)

In the last years it has been shown that many components of tumor microenvironment (TM) can induce cell signaling that permit to breast cancer cells (BC) to maintain their aggressiveness. Ion channels have a role in mediating TM signal; recently we h

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7f8040013cd332ca3397a102217a2ec
https://doi.org/10.1038/s41598-018-37602-7

Abstract 5107: DDR1 and MT1-MMP expression levels are major determinants of 3D type I collagen-induced apoptosis in basal-like breast carcinoma

Autor: Emilie Buache, Erik Maquoi, Frédéric Saltel, Charles Saby, Guillaume Collin, Maha Sinane, Laurence Van Gulick, Hamid Morjani

Publikováno v: Cancer Research. 80:5107-5107

Type I collagen is the major adhesive component in breast interstitial stroma, which represents the first barrier against tumor cell invasion after basement-membrane degradation. Among cellular receptors, type I collagen is able to activate discoidin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15d4349efefacc561bc112721d3b03a8
https://doi.org/10.1158/1538-7445.am2020-5107