Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Laurence Stensland"'
Autor:
Marius Walter, Anoria K. Haick, Rebeccah Riley, Paola A. Massa, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Pavitra Roychoudhury, Martine Aubert, Matthew P. Taylor, Keith R. Jerome, Eric Verdin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Gene drives are genetic modifications designed to propagate efficiently through a population. Most applications rely on homologous recombination during sexual reproduction in diploid organisms such as insects, but we recently developed a gen
Externí odkaz:
https://doaj.org/article/acd1c8473e194f38b1e8720b1d136bac
Autor:
Martine Aubert, Anoria K. Haick, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Meei-Li Huang, Ollivier Hyrien, Daniel Stone, Keith R. Jerome
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Anti-HSV therapies are only suppressive because they do not eliminate latent HSV present in ganglionic neurons, the source of recurrent disease. We have developed a potentially curative approach against HSV infection, based on gene editing u
Externí odkaz:
https://doaj.org/article/9723e7ae8e8b4b0fabbaa81b521d59db
Autor:
Rossana Colón-Thillet, Daniel Stone, Michelle A. Loprieno, Lindsay Klouser, Pavitra Roychoudhury, Tracy K. Santo, Hong Xie, Laurence Stensland, Sarah L. Upham, Gregory Pepper, Meei-Li Huang, Martine Aubert, Keith R. Jerome
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 3 (2023)
ABSTRACT Hepatitis B virus (HBV) is a pathogen of major public health importance that is largely incurable once a chronic infection is established. Only humans and great apes are fully permissive to HBV infection, and this species restriction has imp
Externí odkaz:
https://doaj.org/article/dbccde519db843748d5b366653d72100
Autor:
Daniel Stone, Nadja Meumann, Anne-Sophie Kuhlmann, Christopher W. Peterson, Hong Xie, Pavitra Roychoudhury, Michelle A. Loprieno, Xuan-Khang Vu, Daniel E. Strongin, Elizabeth J. Kenkel, Anoria Haick, Laurence Stensland, Willimark M. Obenza, Jacob Parrott, Veronica Nelson, Robert D. Murnane, Meei-Li Huang, Martine Aubert, Hans-Peter Kiem, Hildegard Büning, Keith R. Jerome
Publikováno v:
Hepatology Communications, Vol 7, Iss 2, Pp e0009-e0009 (2023)
Background and Aims:. Adeno-associated virus (AAV) vectors are widely used to deliver therapeutic transgenes to distinct tissues, including the liver. Vectors based on naturally occurring AAV serotypes as well as vectors using engineered capsids have
Externí odkaz:
https://doaj.org/article/1d40d622a45b4cc6aa011947303c4dea
Autor:
Daniel Stone, Kelly R. Long, Michelle A. Loprieno, Harshana S. De Silva Feelixge, Elizabeth J. Kenkel, R. Matt Liley, Stephen Rapp, Pavitra Roychoudhury, Thuy Nguyen, Laurence Stensland, Rossana Colón-Thillet, Lindsay M. Klouser, Nicholas D. Weber, Connie Le, Jessica Wagoner, Erin A. Goecker, Alvason Zhenhua Li, Karsten Eichholz, Lawrence Corey, D. Lorne Tyrrell, Alexander L. Greninger, Meei-Li Huang, Stephen J. Polyak, Martine Aubert, John E. Sagartz, Keith R. Jerome
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 258-275 (2021)
Chronic hepatitis B virus (HBV) infection is a major public health problem. New treatment approaches are needed because current treatments do not target covalently closed circular DNA (cccDNA), the template for HBV replication, and rarely clear the v
Externí odkaz:
https://doaj.org/article/50136f1751074d8594ac5811c80e88ea
Autor:
Martine Aubert, Daniel E. Strongin, Pavitra Roychoudhury, Michelle A. Loprieno, Anoria K. Haick, Lindsay M. Klouser, Laurence Stensland, Meei-Li Huang, Negar Makhsous, Alexander Tait, Harshana S. De Silva Feelixge, Roman Galetto, Philippe Duchateau, Alexander L. Greninger, Daniel Stone, Keith R. Jerome
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Abstract We evaluate gene editing of HSV in a well-established mouse model, using adeno-associated virus (AAV)-delivered meganucleases, as a potentially curative approach to treat latent HSV infection. Here we show that AAV-delivered meganucleases, b
Externí odkaz:
https://doaj.org/article/f4d037a80a34400ba2411e4046361719
Autor:
Lucrezia Colonna, Christopher W. Peterson, John B. Schell, Judith M. Carlson, Victor Tkachev, Melanie Brown, Alison Yu, Sowmya Reddy, Willi M. Obenza, Veronica Nelson, Patricia S. Polacino, Heather Mack, Shiu-Lok Hu, Katie Zeleski, Michelle Hoffman, Joe Olvera, Scott N. Furlan, Hengqi Zheng, Agne Taraseviciute, Daniel J. Hunt, Kayla Betz, Jennifer F. Lane, Keith Vogel, Charlotte E. Hotchkiss, Cassie Moats, Audrey Baldessari, Robert D. Murnane, Christopher English, Cliff A. Astley, Solomon Wangari, Brian Agricola, Joel Ahrens, Naoto Iwayama, Andrew May, Laurence Stensland, Meei-Li W. Huang, Keith R. Jerome, Hans-Peter Kiem, Leslie S. Kean
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Allogeneic hematopoietic cell transplantation (allo-HCT) has led to the cure of HIV in one individual, but the underlying mechanisms are unclear. Here, the authors present a model of allo-HCT in SHIV-infected nonhuman primates and show that the SHIV
Externí odkaz:
https://doaj.org/article/4a76aae13cb3419a93e2049fc08cebbe
Autor:
Martine Aubert, Nicole M Boyle, Daniel Stone, Laurence Stensland, Meei-Li Huang, Amalia S Magaret, Roman Galetto, David J Rawlings, Andrew M Scharenberg, Keith R Jerome
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 3, Iss C (2014)
Following acute infection, herpes simplex virus (HSV) establishes latency in sensory neurons, from which it can reactivate and cause recurrent disease. Available antiviral therapies do not affect latent viral genomes; therefore, they do not prevent r
Externí odkaz:
https://doaj.org/article/75315e5de9ce43a89af760b711a5b7fd
Autor:
Martine Aubert, Anoria K. Haick, Daniel E. Strongin, Lindsay M. Klouser, Michelle A. Loprieno, Laurence Stensland, Tracy K. Santo, Meei-Li Huang, Ollivier Hyrien, Daniel Stone, Keith R. Jerome
Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system, from which it can reactivate, causing recurrent disease and possible transmission to a new host. Current anti-HSV therapy does not eliminate latent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::591e473f3c6eb9ccc66c2ae4aa54a589
https://doi.org/10.1101/2022.09.23.509057
https://doi.org/10.1101/2022.09.23.509057
Autor:
Martine Aubert, Shiu Lok Hu, Laurence Stensland, Motoko Tanaka, Arjun J Kumar, Christopher W. Peterson, Chul Y. Ahrens, Hans-Peter Kiem, Willimark M. Obenza, Meei-Li Huang, Michelle A. Loprieno, Elizabeth J. Kenkel, Daniel Stone, Harshana S. De Silva Feelixge, Robert D. Murnane, Keith R. Jerome, Solomon Wangari
Publikováno v:
Hum Gene Ther
Adeno-associated virus (AAV) vectors such as AAV6, which shows tropism for primary human CD4(+) T cells in vitro, are being explored for delivery of anti-HIV therapeutic modalities in vivo. However, pre-existing immunity and sequestration in nontarge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44a98e17c5b03af849d2087446f475e1
https://doi.org/10.1089/hum.2020.113
https://doi.org/10.1089/hum.2020.113