Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Laurence Richard"'
Autor:
Amandine Bernard, Mohamad Mroué, Sylvie Bourthoumieu, Malcolm Boyce, Laurence Richard, Franck Sturtz, Claire Demiot, Aurore Danigo
Publikováno v:
Pharmaceuticals, Vol 17, Iss 2, p 144 (2024)
Among the vinca-alkaloid class, vincristine is a potent chemotherapeutic agent with significant neurotoxic effects and is employed to address a wide spectrum of cancer types. Recently, the therapeutic potential of the cholecystokinin type 2 receptor
Externí odkaz:
https://doaj.org/article/0e39ca0e5f31463e81bc1e2f6a015c0f
Autor:
Mohamad Mroué, Flavien Bessaguet, Angélique Nizou, Laurence Richard, Franck Sturtz, Laurent Magy, Sylvie Bourthoumieu, Aurore Danigo, Claire Demiot
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 139 (2024)
The occurrence of neuropathic pain in chemotherapy-induced peripheral neuropathy (CIPN) is a major dose-limiting effect of many commonly-used anticancer agents. Polyvalent human immunoglobulins (hIg), used in the treatment of several peripheral neuro
Externí odkaz:
https://doaj.org/article/e9dd2cc70411450b881a9ba7a395e647
Autor:
Nesrine Benslimane, Federica Miressi, Camille Loret, Laurence Richard, Angélique Nizou, Ioanna Pyromali, Pierre-Antoine Faye, Frédéric Favreau, Fabrice Lejeune, Anne-Sophie Lia
Publikováno v:
Pharmaceuticals, Vol 16, Iss 7, p 1034 (2023)
Nonsense mutations are involved in multiple peripheral neuropathies. These mutations induce the presence of a premature termination codon (PTC) at the mRNA level. As a result, a dysfunctional or truncated protein is synthesized, or even absent linked
Externí odkaz:
https://doaj.org/article/4fcd4e5b984e4e5596c80ec1ced643e1
Autor:
Ioanna Pyromali, Laurence Richard, Paco Derouault, Jean-Michel Vallat, Karima Ghorab, Corinne Magdelaine, Franck Sturtz, Frédéric Favreau, Anne-Sophie Lia
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1565 (2023)
Hereditary sensory neuropathies (HSN) are a heterogenous group of sensory neuropathies. Mutations in ATL3 have been described in patients presenting with hereditary sensory neuropathy IF (HSN1F), a subtype of HSN. Herein, by analyzing targeted-NGS da
Externí odkaz:
https://doaj.org/article/38396eaa0d3e49e9a51bb45d20ac9caa
Autor:
Suzan Boutary, Marie Caillaud, Mévidette El Madani, Jean-Michel Vallat, Julien Loisel-Duwattez, Alice Rouyer, Laurence Richard, Céline Gracia, Giorgia Urbinati, Didier Desmaële, Andoni Echaniz-Laguna, David Adams, Patrick Couvreur, Michael Schumacher, Charbel Massaad, Liliane Massaad-Massade
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Boutary et al. describe siRNA based therapy conjugated with squalene nanoparticles as an efficient approach to normalize PMP22 protein levels, restore locomotor activity, electrophysiological parameters and function of myelin sheath in CMT1A mouse mo
Externí odkaz:
https://doaj.org/article/1040014b286640ea9f55ad4f4445c8c9
Autor:
Nadjet Gacem, Anthula Kavo, Lisa Zerad, Laurence Richard, Stephane Mathis, Raj P. Kapur, Melanie Parisot, Jeanne Amiel, Sylvie Dufour, Pierre de la Grange, Veronique Pingault, Jean Michel Vallat, Nadege Bondurand
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
ADAR1 is an RNA editing protein known to regulate immune responses to dsRNA that has been connected to neural crest cell function. Here, the authors show RNA editing by ADAR1 is important for the normal development of neural crest derived melanocytes
Externí odkaz:
https://doaj.org/article/79a56e3cdbac4d50bb37d28f7c7a9f8e
Autor:
Amandine Bernard, Aurore Danigo, Mohamad Mroué, Amandine Rovini, Laurence Richard, Angélique Nizou, Alexis Desmoulière, Franck Sturtz, Claire Demiot, Sylvie Bourthoumieu
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2823 (2022)
Vincristine (VCR) is responsible for the onset of the VCR-induced peripheral neuropathy (VIPN), associated with neuropathic pain. Several reports have strongly linked the cholecystokinin type 2 receptor (CCK2R) to nociceptive modulation. Thus, our ai
Externí odkaz:
https://doaj.org/article/2e92269a3139401c90be29b1ae67588d
Autor:
Laurent Magy, Pauline Chazelas, Laurence Richard, Nathalie Deschamps, Simon Frachet, Jean-Michel Vallat, Corinne Magdelaine, Frédéric Favreau, Flavien Bessaguet, Anne-Sophie Lia, Mathilde Duchesne
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2046 (2022)
CANVAS, a rare disorder responsible for late-onset ataxia of autosomal recessive inheritance, can be misdiagnosed. We investigated a series of eight patients with sensory neuropathy and/or an unexplained cough, who appeared to suffer from CANVAS, and
Externí odkaz:
https://doaj.org/article/7adb671fc7c64d91b1ecd08b8d3eec2e
Autor:
Hichem Bouchenaki, Aurore Danigo, Amandine Bernard, Flavien Bessaguet, Laurence Richard, Franck Sturtz, David Balayssac, Laurent Magy, Claire Demiot
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
Oxaliplatin is a key drug for colorectal cancer that causes OXP-induced peripheral neuropathy, a dose-limiting effect characterized by cold and tactile hyperesthesia. The relationship between the sensory nervous system and modulation of the renin-ang
Externí odkaz:
https://doaj.org/article/61e12599ce7146209b6c37d1cac333ea
Publikováno v:
Policy & Society, Vol 38, Iss 4, Pp 554-571 (2019)
Although policy instruments are often conceptualized as technical or neutral tools through which ideas and outcomes are connected, this article focuses on the discursive dimensions of policy instruments in Canada’s eldercare policy to explore their
Externí odkaz:
https://doaj.org/article/b9d392f5d1464a69bb271129a3b5bb83