Epi-MEIF: detecting higher order epistatic interactions for complex traits using mixed effect conditional inference forests

Autor: Saswati Saha, Laurent Perrin, Laurence Röder, Christine Brun, Lionel Spinelli

Publikováno v: Nucleic Acids Research
Nucleic Acids Research, 2022, pp.gkac715. ⟨10.1093/nar/gkac715⟩

Understanding the relationship between genetic variations and variations in complex and quantitative phenotypes remains an ongoing challenge. While Genome-wide association studies (GWAS) have become a vital tool for identifying single-locus associati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdda2985e3447aa9dd530def1c60455c
https://hal-amu.archives-ouvertes.fr/hal-03800774/document

Genetic architecture of natural variation of cardiac performance: from flies to Humans

Autor: Alexandre R. Colas, Rolf Bodmer, Laurent Kremmer, Georg Vogler, Laurence Röder, Anaïs Kervadec, Karen Ocorr, Laurent Perrin, Krifa Sallouha, Lionel Spinelli, Magali Torres, Jaime A. Castro-Mondragon, Saswati Saha, Christine Brun

Background Deciphering the genetic architecture of cardiac disorders is of fundamental importance but their underlying complexity is a major hurdle. Drosophila has gained importance as a useful model to study heart development and function and allows

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c09ac2a8f24d463337bfeae71d2c592
https://doi.org/10.1101/2021.06.08.447524

Pathologies et vieillissement cardiaque

Autor: Laurence Röder, Laurent Perrin

Publikováno v: médecine/sciences. 32:470-477

The high level of conservation of the cardiogenic gene regulatory network as well as of the cellular and physiological characteristics of the cardiomyocytes between fly and human, makes the small heart of this invertebrate the simplest and most flexi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ed9dc5d0d65e144b5033029be0969fd6
https://doi.org/10.1051/medsci/20163205013

Identification and in silico modeling of enhancers reveals new features of the cardiac differentiation network

Autor: Denis Seyres, Ouarda Taghli-Lamallem, Guillaume Junion, Yad Ghavi-Helm, Céline Guichard, Laurent Perrin, Laurence Röder, Eileen E. M. Furlong, Charles Girardot

Publikováno v: Development
Development, 2016, 143 (23), pp.4533--4542. ⟨10.1242/dev.140822⟩
Development (Cambridge, England)
Development (Cambridge, England), Company of Biologists, 2016, 143 (23), pp.4533-4542. ⟨10.1242/dev.140822⟩
Development (Cambridge, England), 2016, 143 (23), pp.4533-4542. ⟨10.1242/dev.140822⟩

Developmental patterning and tissue formation are regulated through complex gene regulatory networks (GRNs) driven through the action of transcription factors (TFs) converging on enhancer elements. Here, as a point of entry to dissect the poorly defi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7003794481dbcbbf426ec9d417e80d88
https://pubmed.ncbi.nlm.nih.gov/27899510

Approaches combining mice and Drosophila melanogaster models to decipher human sepsis

Autor: Cong Tu Nguyen, Pascal Rihet, Laurence Röder, Séverine Garnier, Béatrice Loriod, Laurent Perrin, R Ramy, Lydie Pradel, Arnaud Defaye

Publikováno v: Critical Care
Critical Care, BioMed Central, 2014, 18 (S2), ⟨10.1186/cc14070⟩
Critical Care, 2014, 18 (S2), ⟨10.1186/cc14070⟩

Sepsis is a complex and heterogeneous syndrome in which inflammatory and infection mechanisms are implicated. Thus, it is difficult to differentiate those mechanisms in mammals where inflammation is a highly complex biological process. In our laborat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::003689bf903c25879e99bf657f3e8a47
https://doi.org/10.1186/cc14070