A stratification strategy to predict secondary infection in critical illness-induced immune dysfunction: the REALIST score

Autor: Jan-Alexis Tremblay, Florian Peron, Louis Kreitmann, Julien Textoris, Karen Brengel-Pesce, Anne-Claire Lukaszewicz, Laurence Quemeneur, Christophe Vedrine, Lionel K. Tan, Fabienne Venet, Thomas Rimmele, Guillaume Monneret, the REALISM study group

Publikováno v: Annals of Intensive Care, Vol 12, Iss 1, Pp 1-10 (2022)

Abstract Background Although multiple individual immune parameters have been demonstrated to predict the occurrence of secondary infection after critical illness, significant questions remain with regards to the selection, timing and clinical utility

Externí odkaz: https://doaj.org/article/64a83ce0b7204b1eb7df7c0e40cab769

Monocyte Trajectories Endotypes Are Associated With Worsening in Septic Patients

Autor: Maxime Bodinier, Estelle Peronnet, Karen Brengel-Pesce, Filippo Conti, Thomas Rimmelé, Julien Textoris, Christophe Vedrine, Laurence Quemeneur, Andrew D. Griffiths, Lionel K. Tan, Fabienne Venet, Delphine Maucort-Boulch, Guillaume Monneret, the REALISM study group

Publikováno v: Frontiers in Immunology, Vol 12 (2021)

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection. The immune system plays a key role in sepsis onset and remains dysregulated over time in a heterogeneous manner. Here, we decipher the heterogeneity o

Externí odkaz: https://doaj.org/article/2cd9c0d146304e6d83a767d4e12c26e6

Concomitant Assessment of Monocyte HLA-DR Expression and Ex Vivo TNF-α Release as Markers of Adverse Outcome after Various Injuries—Insights from the REALISM Study

Autor: Frank Bidar, Maxime Bodinier, Fabienne Venet, Anne-Claire Lukaszewicz, Karen Brengel-Pesce, Filippo Conti, Laurence Quemeneur, Philippe Leissner, Lionel K. Tan, Julien Textoris, Thomas Rimmelé, Guillaume Monneret, on behalf of the Realism Study Group

Publikováno v: Journal of Clinical Medicine; Volume 11; Issue 1; Pages: 96
Journal of Clinical Medicine, Vol 11, Iss 96, p 96 (2022)
Journal of Clinical Medicine
Journal of Clinical Medicine, 2022, 11 (1), pp.96. ⟨10.3390/jcm11010096⟩

Intensive care unit (ICU) patients develop an altered host immune response after severe injuries. This response may evolve towards a state of persistent immunosuppression that is associated with adverse clinical outcomes. The expression of human leuk

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c34cc35ed0737ca91aeb4d16f0c7f3d6

Deciphering the domain specificity of C. difficile toxin neutralizing antibodies

Autor: Lucianna Barone, Kristl M Pacheco, Lu Li, Fuqin Ma, Christopher Rogers, Utsav Jetley, Yanhua Yan, Nicola Beltraminelli, Laurence Quemeneur, Leah E. Cole, Jinrong Zhang, Harry Kleanthous, Natalie G. Anosova, Stephen Anderson, Sophia Mundle, Jianxin Zhang

Publikováno v: Vaccine. 37:3892-3901

Clostridium difficile infection (CDI) is the principal cause of nosocomial diarrhea and pseudomembranous colitis associated with antibiotic therapy. The pathological effects of CDI are primarily attributed to toxins A (TcdA) and B (TcdB). Adequate to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::992883bcc614bec8ec9d5fb502976504
https://doi.org/10.1016/j.vaccine.2019.05.040

Clostridium difficile Toxoid Vaccine Candidate Confers Broad Protection against a Range of Prevalent Circulating Strains in a Nonclinical Setting

Autor: Patricia J Pietrobon, Nadège Arnaud-Barbe, Nadine Petiot, Laurence Quemeneur, Patricia Londoño-Hayes, Catherine Hessler

Publikováno v: Infection and Immunity

Clostridium difficile infection (CDI) is a leading cause of nosocomial and antibiotic-associated diarrhea. A vaccine, based on formalin-inactivated toxins A and B purified from anaerobic cultures of C. difficile strain VPI 10463 (toxinotype 0), has b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8571ff97b0a6358d46dbccee27200ec0
https://doi.org/10.1128/iai.00742-17