Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Laurence Pibouin"'
Autor:
Kevin Boyé, Luiz Henrique Geraldo, Jessica Furtado, Laurence Pibouin-Fragner, Mathilde Poulet, Doyeun Kim, Bryce Nelson, Yunling Xu, Laurent Jacob, Nawal Maissa, Dritan Agalliu, Lena Claesson-Welsh, Susan L. Ackerman, Anne Eichmann
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The authors show that Netrin-1-Unc5B signaling controls blood-brain barrier integrity by maintaining Wnt/b-catenin signaling and that delivery of antibodies blocking Netrin-1 binding to Unc5B causes transient and size-selective BBB breakdown.
Externí odkaz:
https://doaj.org/article/7945797555614051a865fa97526dfd6d
Autor:
Gael Genet, Kevin Boyé, Thomas Mathivet, Roxana Ola, Feng Zhang, Alexandre Dubrac, Jinyu Li, Nafiisha Genet, Luiz Henrique Geraldo, Lorena Benedetti, Steffen Künzel, Laurence Pibouin-Fragner, Jean-Leon Thomas, Anne Eichmann
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
VEGF-A/VEGFR2 signaling is a key driver of endothelial cell migration during sprouting angiogenesis. Here Genet et al. show that endophilin A2 regulates these processes by mediating clathrin-independent VEGFR2 internalization.
Externí odkaz:
https://doaj.org/article/a65242a5aee94d9999a57269b93f9bd4
Autor:
Feng Zhang, Claudia Prahst, Thomas Mathivet, Laurence Pibouin-Fragner, Jiasheng Zhang, Gael Genet, Raymond Tong, Alexandre Dubrac, Anne Eichmann
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
Robo4 is a transmembrane protein that regulates vascular permeability. Zhang et al. now reveal the mechanism of Robo4 action and show that Robo4 and UncB are required for VEGF-mediated regulation of vascular barrier by suppressing VEGF-induced phosph
Externí odkaz:
https://doaj.org/article/96fad901a4ef46c28beb417658674b86
Autor:
Jessica Furtado, Luiz Henrique Geraldo, Felipe Saceanu Leser, Mathilde Poulet, Hyojin Park, Laurence Pibouin-Fragner, Anne Eichmann, Kevin Boyé
BackgroundThe blood brain barrier (BBB) preserves neuronal function in the central nervous system (CNS) by tightly controlling metabolite exchanges with the blood. In the eye, the retina is likewise protected by the blood-retina barrier (BRB) to main
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a259d483b95e3bbb9473b58b82b56fb5
https://doi.org/10.1101/2023.01.21.525006
https://doi.org/10.1101/2023.01.21.525006
Autor:
Jinah Han, Charles-Félix Calvo, Tae Hyuk Kang, Kasey L. Baker, June-Hee Park, Carlos Parras, Marine Levittas, Ulrick Birba, Laurence Pibouin-Fragner, Pascal Fragner, Kaya Bilguvar, Ronald S. Duman, Harri Nurmi, Kari Alitalo, Anne C. Eichmann, Jean-Léon Thomas
Publikováno v:
Cell Reports, Vol 10, Iss 7, Pp 1158-1172 (2015)
Neural stem cells (NSCs) continuously produce new neurons within the adult mammalian hippocampus. NSCs are typically quiescent but activated to self-renew or differentiate into neural progenitor cells. The molecular mechanisms of NSC activation remai
Externí odkaz:
https://doaj.org/article/315ad1d0e24c4d85a80af7b8470c6a50
Autor:
Christelle Damon-Soubeyrand, Antonino Bongiovanni, Areski Chorfa, Chantal Goubely, Nelly Pirot, Luc Pardanaud, Laurence Pibouin-Fragner, Caroline Vachias, Stéphanie Bravard, Rachel Guiton, Jean-Léon Thomas, Fabrice Saez, Ayhan Kocer, Meryem Tardivel, Joël R. Drevet, Joelle Henry-Berger
Long considered an accessory tubule of the male reproductive system, the epididymis is proving to be a key determinant of male fertility. In addition to its secretory role in ensuring functional maturation and survival of spermatozoa, the epididymis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::05174a2d93517ca9b493a515817c9eb8
https://doi.org/10.1101/2022.08.26.505406
https://doi.org/10.1101/2022.08.26.505406
Publikováno v:
Cellular and Molecular Life Sciences. 79
Endothelial cells in veins differ in morphology, function and gene expression from those in arteries and lymphatics. Understanding how venous and arterial identities are induced during development is required to understand how arterio-venous malforma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f93556016517ce8ecf669e3a4e86bdb9
https://doi.org/10.1007/s00018-022-04470-4
https://doi.org/10.1007/s00018-022-04470-4
Autor:
Joost Dejaegher, Anne Eichmann, Maite Verreault, Flavia Regina Souza Lima, Andreas Bikfalvi, Marc Sanson, Thomas Mathivet, Q. Richard Lu, Corinne Lesaffre, Yunling Xu, Luiz Henrique Medeiros Geraldo, Lien Solie, Ahmed Idbaih, Justine Rudewicz, Jean-Leon Thomas, Thomas Viel, Camille Knosp, Laurent Jacob, Rohit Rao, Bertrand Tavitian, Nolwenn Lemaire, Nawal Maïssa, Thomas Daubon, Steven De Vleeschouwer, Laurence Pibouin-Fragner
Publikováno v:
J Clin Invest
The Journal of clinical investigation
The Journal of clinical investigation, 2021, 131 (16), ⟨10.1172/JCI141083⟩
The Journal of clinical investigation
The Journal of clinical investigation, 2021, 131 (16), ⟨10.1172/JCI141083⟩
SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and 2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in gliomas. In patients with glioblastoma (GBM), SLIT2 expression increased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d27effe9ebf196e59730db20b0bba20
https://doi.org/10.1172/jci141083
https://doi.org/10.1172/jci141083
Autor:
Doyeun Kim, Jessica Furtado, Laurent Jacob, Laurence Pibouin-Fragner, Lena Claesson-Welsh, Nawal Maïssa, Dritan Agalliu, Y. Xu, Anne Eichmann, Kevin Boyé, Mathilde Poulet, Geraldo Lh, Bertrand Tavitian, Susan L. Ackerman, Nelson B
Blood-brain barrier (BBB) integrity is critical for proper function of the central nervous system (CNS). Here, we showed that the endothelial Netrin1 receptor Unc5B controls BBB integrity by maintaining Wnt/β–catenin signaling. Inducible endotheli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aa7194a26113c3fe3e43b4fdb4c56837
https://doi.org/10.1101/2021.05.06.442974
https://doi.org/10.1101/2021.05.06.442974
Autor:
Lien Solie, Maite Verreault, Q. R. Lu, S. De Vleeschouwer, Camille Knosp, Joost Dejaegher, N. Lemaire, Ahmed Idbaih, Bertrand Tavitian, Luiz H. Geraldo, Anne Eichmann, Thomas Viel, Thomas Daubon, Thomas Mathivet, Marc Sanson, Justine Rudewicz, Nawal Maïssa, Jean-Leon Thomas, Laurence Pibouin-Fragner, Flavia Regina Souza Lima, Laurent Jacob, Rohit Rao, Andreas Bikfalvi, Corinne Lesaffre, Y. Xu
SLIT2 is a secreted polypeptide that guides migration of cells expressing ROBO1&2 receptors. Herein, we investigated SLIT2/ROBO signaling effects in gliomas. In patients with glioblastoma (GBM), SLIT2 expression increased with malignant progression a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d0ef6a37085feefddbcabd6a229dc1a6
https://doi.org/10.1101/2021.04.12.438457
https://doi.org/10.1101/2021.04.12.438457