Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Laurence O.W. Wilson"'
Autor:
Suzanne Scott, Adrian Westhaus, Deborah Nazareth, Marti Cabanes-Creus, Renina Gale Navarro, Deborah Chandra, Erhua Zhu, Aravind Venkateswaran, Ian E. Alexander, Denis C. Bauer, Laurence O.W. Wilson, Leszek Lisowski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 4, Pp 101351- (2024)
Gene therapies using recombinant adeno-associated virus (AAV) vectors have demonstrated considerable clinical success in the treatment of genetic disorders. Improved vectors with favorable tropism profiles, decreased immunogenicity, and enhanced manu
Externí odkaz:
https://doaj.org/article/6a6bf17f07fb448284aae0543a3f1d82
Autor:
Marti Cabanes-Creus, Renina Gale Navarro, Erhua Zhu, Grober Baltazar, Sophia H.Y. Liao, Matthieu Drouyer, Anais K. Amaya, Suzanne Scott, Loan Hanh Nguyen, Adrian Westhaus, Matthias Hebben, Laurence O.W. Wilson, Adrian J. Thrasher, Ian E. Alexander, Leszek Lisowski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 24, Iss , Pp 88-101 (2022)
Recent clinical successes have intensified interest in using adeno-associated virus (AAV) vectors for therapeutic gene delivery. The liver is a key clinical target, given its critical physiological functions and involvement in a wide range of genetic
Externí odkaz:
https://doaj.org/article/1abf6bd1dabc4da8b922b404440e19d1
Autor:
Priya Ramarao-Milne, Yatish Jain, Letitia M.F. Sng, Brendan Hosking, Carol Lee, Arash Bayat, Michael Kuiper, Laurence O.W. Wilson, Natalie A. Twine, Denis C. Bauer
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 2942-2950 (2022)
New SARS-CoV-2 variants emerge as part of the virus’ adaptation to the human host. The Health Organizations are monitoring newly emerging variants with suspected impact on disease or vaccination efficacy as Variants Being Monitored (VBM), like Delt
Externí odkaz:
https://doaj.org/article/8e6feb29918e4976bf4737d0e7397e96
Autor:
Marti Cabanes-Creus, Renina Gale Navarro, Sophia H.Y. Liao, Grober Baltazar, Matthieu Drouyer, Erhua Zhu, Suzanne Scott, Clement Luong, Laurence O.W. Wilson, Ian E. Alexander, Leszek Lisowski
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 21, Iss , Pp 607-620 (2021)
Recent successes in clinical gene therapy applications have intensified the interest in using adeno-associated viruses (AAVs) as vectors for gene delivery into human liver. An inherent intriguing characteristic of AAVs is that vector variants vary su
Externí odkaz:
https://doaj.org/article/c6035f1c9a8f453c82104f8bd5281f81
Autor:
Suzanne Scott, Susanna Grigson, Felix Hartkopf, Claus V. Hallwirth, Ian E. Alexander, Denis C. Bauer, Laurence O.W. Wilson
Publikováno v:
Data in Brief, Vol 42, Iss , Pp 108161- (2022)
Viral integration is a complex biological process, and it is useful to have a reference integration dataset with known properties to compare experimental data against, or for comparing with the results from computational tools that detect integration
Externí odkaz:
https://doaj.org/article/3361f4494be64f42a53a4eea6dc2497c
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss , Pp 3810-3816 (2021)
External DNA sequences can be inserted into an organism’s genome either through natural processes such as gene transfer, or through targeted genome engineering strategies. Being able to robustly identify such foreign DNA is a crucial capability for
Externí odkaz:
https://doaj.org/article/2f6d6e0669f54c6ea845fbad8bf041a9
Autor:
Geneviève Almouzni, Paul Cottu, Yves Pommier, Alfonso Valencia, David Gentien, Elisabetta Marangoni, Cecile Reyes, Fabricio G. Sousa, Sophie Postel-Vinay, Vera Pancaldi, Laurence O.W. Wilson, Zachary A. Gurard-Levin
Chromatin regulators included in this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a423e4fe926d98beaac38125a69a32a
https://doi.org/10.1158/1535-7163.22508128
https://doi.org/10.1158/1535-7163.22508128
Autor:
Geneviève Almouzni, Paul Cottu, Yves Pommier, Alfonso Valencia, David Gentien, Elisabetta Marangoni, Cecile Reyes, Fabricio G. Sousa, Sophie Postel-Vinay, Vera Pancaldi, Laurence O.W. Wilson, Zachary A. Gurard-Levin
Clinical characteristics of the Institut Curie patient cohort
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ba239b060c02319ce92195f91b3624
https://doi.org/10.1158/1535-7163.22508110.v1
https://doi.org/10.1158/1535-7163.22508110.v1
Autor:
Adrian Westhaus, Marti Cabanes-Creus, Kimberley L. Dilworth, Erhua Zhu, David Salas Gómez, Renina G. Navarro, Anais K. Amaya, Suzanne Scott, Magdalena Kwiatek, Alexandra L. McCorkindale, Tara E. Hayman, Silke Frahm, Dany P. Perocheau, Bang Manh Tran, Elizabeth Vincan, Sharon L. Wong, Shafagh A. Waters, Georgina E. Riddiough, Marcos V. Perini, Laurence O.W. Wilson, Julien Baruteau, Sebastian Diecke, Gloria González-Aseguinolaza, Giorgia Santilli, Adrian J. Thrasher, Ian E. Alexander, Leszek Lisowski
The liver is a prime target for in vivo gene therapies using recombinant adeno-associated viral vectors (rAAV). Multiple clinical trials have been undertaken for this target in the past 15 years, however we are still to see market approval of the fir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::456eba301b4b73f9427328cdc937aa92
http://edoc.mdc-berlin.de/23212/1/23212oa.pdf
http://edoc.mdc-berlin.de/23212/1/23212oa.pdf
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 19, Iss, Pp 3810-3816 (2021)
Computational and Structural Biotechnology Journal
Computational and Structural Biotechnology Journal
Graphical abstract
External DNA sequences can be inserted into an organism’s genome either through natural processes such as gene transfer, or through targeted genome engineering strategies. Being able to robustly identify such foreign DNA is
External DNA sequences can be inserted into an organism’s genome either through natural processes such as gene transfer, or through targeted genome engineering strategies. Being able to robustly identify such foreign DNA is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e116e9f9c13f92319fe632d687e292b
https://doi.org/10.1016/j.csbj.2021.06.045
https://doi.org/10.1016/j.csbj.2021.06.045