Zobrazeno 1 - 10
of 163
pro vyhledávání: '"Laurence O. Trussell"'
Publikováno v:
eLife, Vol 12 (2024)
Cartwheel interneurons of the dorsal cochlear nucleus (DCN) potently suppress multisensory signals that converge with primary auditory afferent input, and thus regulate auditory processing. Noradrenergic fibers from locus coeruleus project to the DCN
Externí odkaz:
https://doaj.org/article/d670d0361fef4194a72f886971dc2474
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
The dorsal cochlear nucleus (DCN) is the first site of multisensory integration in the auditory pathway of mammals. The DCN circuit integrates non-auditory information, such as head and ear position, with auditory signals, and this convergence may co
Externí odkaz:
https://doaj.org/article/03cbe5f2aa104d88b51904cd1b5c32b4
Autor:
Gabriel E Romero, Laurence O Trussell
Publikováno v:
eLife, Vol 10 (2021)
Activity in each brain region is shaped by the convergence of ascending and descending axonal pathways, and the balance and characteristics of these determine the neural output. The medial olivocochlear (MOC) efferent system is part of a reflex arc t
Externí odkaz:
https://doaj.org/article/d5263c9a1808421ba41828ab165a865e
Publikováno v:
eLife, Vol 10 (2021)
Synapses of glutamatergic mossy fibers (MFs) onto cerebellar unipolar brush cells (UBCs) generate slow excitatory (ON) or inhibitory (OFF) postsynaptic responses dependent on the complement of glutamate receptors expressed on the UBC’s large dendri
Externí odkaz:
https://doaj.org/article/40bcaadd705042619bc680f3d0f1cc81
Publikováno v:
eLife, Vol 9 (2020)
Auditory processing depends upon inhibitory signaling by interneurons, even at its earliest stages in the ventral cochlear nucleus (VCN). Remarkably, to date only a single subtype of inhibitory neuron has been documented in the VCN, a projection neur
Externí odkaz:
https://doaj.org/article/ae653638f2c9436882698a6ae1f1c5be
Autor:
Zheng-Quan Tang, Laurence O. Trussell
Publikováno v:
Cell Reports, Vol 20, Iss 8, Pp 1844-1854 (2017)
Many studies have explored how neuromodulators affect synaptic function, yet little is known about how they modify computations at the microcircuit level. In the dorsal cochlear nucleus (DCN), a region that integrates auditory and multisensory inputs
Externí odkaz:
https://doaj.org/article/7afe025b24a04623982d0bf5e1327015
Autor:
Timothy S Balmer, Laurence O Trussell
Publikováno v:
eLife, Vol 8 (2019)
In vestibular cerebellum, primary afferents carry signals from single vestibular end organs, whereas secondary afferents from vestibular nucleus carry integrated signals. Selective targeting of distinct mossy fibers determines how the cerebellum proc
Externí odkaz:
https://doaj.org/article/ad7066654f7b4e2f8d8119d749a21a3d
Autor:
Junzhan Jing, Ming Hu, Tenzin Ngodup, Qianqian Ma, Shu Ning Natalie Lau, Cecilia Ljungberg, Matthew J. McGinley, Laurence O. Trussell, Xiaolong Jiang
Publikováno v:
bioRxiv
The cochlear nucleus (CN), the starting point for all central auditory processing, comprises a suite of neuronal cell types that are morphologically and biophysically specialized for initiating parallel pathways, yet their molecular distinctions are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ff8b76a1e7eb6c8e9620d7c6fb075c0
https://doi.org/10.1101/2023.05.15.539065
https://doi.org/10.1101/2023.05.15.539065
Publikováno v:
J Neurosci
The presynaptic action potential (AP) is required to drive calcium influx into nerve terminals, resulting in neurotransmitter release. Accordingly, the AP waveform is crucial in determining the timing and strength of synaptic transmission. The calyx
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56628f11b37eb9ea3403a7ea35fb9b9d
https://doi.org/10.1523/jneurosci.0363-20.2022
https://doi.org/10.1523/jneurosci.0363-20.2022
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Efferent neurons are believed to play essential roles in maintaining auditory function. The lateral olivocochlear (LOC) neurons—which project from the brainstem to the inner ear, where they release multiple transmitters including peptides, catechol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e155988cdd3363a1df40007196df4b4f
https://doi.org/10.1073/pnas.2209565119
https://doi.org/10.1073/pnas.2209565119