Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Laurence Novo-Perez"'
Autor:
Anthony Nichols, David Covini, Anna Quattropani, Jean-François Arrighi, Yves Cambet, Maurizio Maio, Thierry Martin, Olivier Schott, Bernard Françon, Laurence Novo-Perez, Don Simpson, Delphine Marin, Delphine Rivron, Cristina Donini, Agnes Bombrun, Pierre-Alain Vitte, Stefano Crosignani, Wolfgang H. B. Sauer, Isabelle Martinou, Dominique Swinnen, Valerie Eligert, Fabienne Burgat-Charvillon
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:1516-1519
The discovery of a novel series of S1P1 agonists is described. Starting from a micromolar HTS positive, iterative optimization gave rise to several single-digit nanomolar S1P1 agonists. The compounds were able to induce internalization of the S1P1 re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016d011f2a43aa5c6d794dc932148d8b
https://doi.org/10.1016/j.bmcl.2010.01.102
https://doi.org/10.1016/j.bmcl.2010.01.102
Autor:
Alexander Scheer, Paul Lang, Pascale Gaillard, Jean-Pierre Gotteland, Laurence Novo-Perez, Patrick Page, Karen Yeow
Publikováno v:
ASSAY and Drug Development Technologies. 4:451-460
Glycogen synthase kinase-3 (GSK3) is a serine-threonine protein kinase that exists as two isozymes, GSK3alpha and GSK3beta. It plays important roles in regulating cell structure, function, and survival, and dysregulation of its function is linked to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd65c3dfaaa014652d73b9b357dd5568
https://doi.org/10.1089/adt.2006.4.451
https://doi.org/10.1089/adt.2006.4.451
Autor:
Sebastien Nock, Valerie Eligert, Stefano Crosignani, Manfred Schneider, Agnes Bombrun, Adriano Luis Soares de Souza, Anna Quattropani, Delphine Marin, Susanna Carboni, Fanny Beltran, Patrick Gerber, Jerome Gonzalez, Pierre-Alain Vitte, Jerome Dorbais, Ursula Boschert, Katrin Georgi, Laurence Novo-Perez, Anthony Nichols, Mathilde Muzerelle, Wolfgang H. B. Sauer, Jennifer Hantson, Jean-François Arrighi
Publikováno v:
ChemMedChem. 10(4)
Sphingosine-1-phosphate (S1P) receptor agonists have shown promise as therapeutic agents for multiple sclerosis (MS) due to their regulatory roles within the immune, central nervous system, and cardiovascular system. Here, the design and optimization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3f80d36b98d5c2c0d0c39b6edbe49c6
https://pubmed.ncbi.nlm.nih.gov/25735812
https://pubmed.ncbi.nlm.nih.gov/25735812
Autor:
Isruth Hussain, Paul Smith, Laurence Anderes, Laurence Novo-Perez, Bruno Permanne, Valerie Eligert, Dirk Beher, Solenne Ousson, Anna Quattropani
Publikováno v:
Alzheimer's & Dementia. 7
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6110676a8bfe837ed9c3b4ae924c63e9
https://doi.org/10.1016/j.jalz.2011.05.324
https://doi.org/10.1016/j.jalz.2011.05.324
Autor:
Karen Yeow, Laurence Novo-Perez, Pascale Gaillard, Patrick Page, Jean-Pierre Gotteland, Alexander Scheer, Paul Lang
Publikováno v:
Assay & Drug Development Technologies; Aug2006, Vol. 4 Issue 4, p451-460, 10p