Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants

Autor: Tokhir Dadaev, Edward J. Saunders, Paul J. Newcombe, Ezequiel Anokian, Daniel A. Leongamornlert, Mark N. Brook, Clara Cieza-Borrella, Martina Mijuskovic, Sarah Wakerell, Ali Amin Al Olama, Fredrick R. Schumacher, Sonja I. Berndt, Sara Benlloch, Mahbubl Ahmed, Chee Goh, Xin Sheng, Zhuo Zhang, Kenneth Muir, Koveela Govindasami, Artitaya Lophatananon, Victoria L. Stevens, Susan M. Gapstur, Brian D. Carter, Catherine M. Tangen, Phyllis Goodman, Ian M. Thompson, Jyotsna Batra, Suzanne Chambers, Leire Moya, Judith Clements, Lisa Horvath, Wayne Tilley, Gail Risbridger, Henrik Gronberg, Markus Aly, Tobias Nordström, Paul Pharoah, Nora Pashayan, Johanna Schleutker, Teuvo L. J. Tammela, Csilla Sipeky, Anssi Auvinen, Demetrius Albanes, Stephanie Weinstein, Alicja Wolk, Niclas Hakansson, Catharine West, Alison M. Dunning, Neil Burnet, Lorelei Mucci, Edward Giovannucci, Gerald Andriole, Olivier Cussenot, Géraldine Cancel-Tassin, Stella Koutros, Laura E. Beane Freeman, Karina Dalsgaard Sorensen, Torben Falck Orntoft, Michael Borre, Lovise Maehle, Eli Marie Grindedal, David E. Neal, Jenny L. Donovan, Freddie C. Hamdy, Richard M. Martin, Ruth C. Travis, Tim J. Key, Robert J. Hamilton, Neil E. Fleshner, Antonio Finelli, Sue Ann Ingles, Mariana C. Stern, Barry Rosenstein, Sarah Kerns, Harry Ostrer, Yong-Jie Lu, Hong-Wei Zhang, Ninghan Feng, Xueying Mao, Xin Guo, Guomin Wang, Zan Sun, Graham G. Giles, Melissa C. Southey, Robert J. MacInnis, Liesel M. FitzGerald, Adam S. Kibel, Bettina F. Drake, Ana Vega, Antonio Gómez-Caamaño, Laura Fachal, Robert Szulkin, Martin Eklund, Manolis Kogevinas, Javier Llorca, Gemma Castaño-Vinyals, Kathryn L. Penney, Meir Stampfer, Jong Y. Park, Thomas A. Sellers, Hui-Yi Lin, Janet L. Stanford, Cezary Cybulski, Dominika Wokolorczyk, Jan Lubinski, Elaine A. Ostrander, Milan S. Geybels, Børge G. Nordestgaard, Sune F. Nielsen, Maren Weisher, Rasmus Bisbjerg, Martin Andreas Røder, Peter Iversen, Hermann Brenner, Katarina Cuk, Bernd Holleczek, Christiane Maier, Manuel Luedeke, Thomas Schnoeller, Jeri Kim, Christopher J. Logothetis, Esther M. John, Manuel R. Teixeira, Paula Paulo, Marta Cardoso, Susan L. Neuhausen, Linda Steele, Yuan Chun Ding, Kim De Ruyck, Gert De Meerleer, Piet Ost, Azad Razack, Jasmine Lim, Soo-Hwang Teo, Daniel W. Lin, Lisa F. Newcomb, Davor Lessel, Marija Gamulin, Tomislav Kulis, Radka Kaneva, Nawaid Usmani, Chavdar Slavov, Vanio Mitev, Matthew Parliament, Sandeep Singhal, Frank Claessens, Steven Joniau, Thomas Van den Broeck, Samantha Larkin, Paul A. Townsend, Claire Aukim-Hastie, Manuela Gago-Dominguez, Jose Esteban Castelao, Maria Elena Martinez, Monique J. Roobol, Guido Jenster, Ron H. N. van Schaik, Florence Menegaux, Thérèse Truong, Yves Akoli Koudou, Jianfeng Xu, Kay-Tee Khaw, Lisa Cannon-Albright, Hardev Pandha, Agnieszka Michael, Andrzej Kierzek, Stephen N. Thibodeau, Shannon K. McDonnell, Daniel J. Schaid, Sara Lindstrom, Constance Turman, Jing Ma, David J. Hunter, Elio Riboli, Afshan Siddiq, Federico Canzian, Laurence N. Kolonel, Loic Le Marchand, Robert N. Hoover, Mitchell J. Machiela, Peter Kraft, The PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium, Matthew Freedman, Fredrik Wiklund, Stephen Chanock, Brian E. Henderson, Douglas F. Easton, Christopher A. Haiman, Rosalind A. Eeles, David V. Conti, Zsofia Kote-Jarai

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)

Prostate cancer (PrCa) involves a large heritable genetic component. Here, the authors perform multivariate fine-mapping of known PrCa GWAS loci, identifying variants enriched for biological function, explaining more familial relative risk, and with

Externí odkaz: https://doaj.org/article/36e01625dae94bd89d2103af9c540d34

Data from Tobacco and Alcohol in Relation to Male Breast Cancer: An Analysis of the Male Breast Cancer Pooling Project Consortium

Autor: Louise A. Brinton, Walter C. Willett, David B. Thomas, Anthony Swerdlow, Howard D. Sesso, Elio Riboli, Eleni Th. Petridou, Dominick Parisi, Håkan Olsson, Eva Negri, Valerie A. McCormack, Jay H. Lubin, Elsebeth Lynge, Carlo La Vecchia, Laurence N. Kolonel, Kenneth Johnson, Ann W. Hsing, Laurel A. Habel, George Gkiokas, Mia M. Gaudet, Roni T. Falk, Marianne Ewertz, Stephen K. Van Den Eeden, Rosie Cooke, John T. Casagrande, Karin B. Michels, Piet A. van den Brandt, Susan M. Gapstur, Pascal Guénel, Michael B. Cook

Background: The etiology of male breast cancer is poorly understood, partly due to its relative rarity. Although tobacco and alcohol exposures are known carcinogens, their association with male breast cancer risk remains ill-defined.Methods: The Male

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1468e508abda9500f840569c226007ad
https://doi.org/10.1158/1055-9965.c.6516364.v1

Supplementary Figure S1 from Characterizing Genetic Susceptibility to Breast Cancer in Women of African Ancestry

Autor: Christopher A. Haiman, Julie R. Palmer, Olufunmilayo I. Olopade, Daniel O. Stram, Gerhard A. Coetzee, David V. Conti, Laurence N. Kolonel, Andrew F. Olshan, Loic Le Marchand, Stephen J. Chanock, Jeannette T. Bensen, Lara E. Sucheston-Campbell, Kathryn L. Lunetta, Katherine L. Nathanson, Lisa Signorello, Qiuyin Cai, William Blot, Stefan Ambs, Barbara Nemesure, Anselm Hennis, Adeyinka G. Falusi, Oladosu Ojengbede, Clement Adebamowo, Timothy R. Rebbeck, Temidayo O. Ogundiran, Yoo-Jeong Han, Song Yao, Yonglan Zheng, Jorge L. Rodriguez-Gil, Sandra L. Deming, Michael F. Press, Sue A. Ingles, Elisa V. Bandera, Sarah Nyante, Regina G. Ziegler, Jennifer J. Hu, Wei Zheng, Leslie Bernstein, Esther M. John, Christine B. Ambrosone, Stephen A. Haddad, Edward A. Ruiz-Narvaez, Dezheng Huo, Suhn Kyong Rhie, Ye Feng

Supplementary Figure S1, Supplementary Figure S1. Regional plots of 3p24, 11q13, 12p11, 14q13, 16q12/TOX3, 16q12/FTO, 16q23, and 19p13.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2953e406dedef5f0a92b74783aedd3b9
https://doi.org/10.1158/1055-9965.22436277

Supplementary Table 1 from CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium

Autor: David J. Hunter, Loïc Le Marchand, Jarmo Virtamo, Paolo Vineis, Dimitrios Trichopoulos, Anne Tjønneland, Michael J. Thun, Daniel O. Stram, Meir Stampfer, Elio Riboli, Laudina Rodriguez, Jing Ma, Laurence N. Kolonel, Rudolf Kaaks, Brian E. Henderson, Christopher A. Haiman, Edward Giovannucci, J. Michael Gaziano, Heather Spencer Feigelson, Richard Hayes, Alison M. Dunning, Stephen Chanock, Eugenia E. Calle, H. Bas Bueno-de-Mesquita, Heiner Boeing, Sonja I. Berndt, Goran Berglund, Demetrius Albanes, Naomi E. Allen, Peter Kraft, Joel N. Hirschhorn, Fredrick Schumacher, Ruth C. Travis

Supplementary Table 1 from CYP19A1 Genetic Variation in Relation to Prostate Cancer Risk and Circulating Sex Hormone Concentrations in Men from the Breast and Prostate Cancer Cohort Consortium

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3052e53d754d2441fc59667e75270cfd
https://doi.org/10.1158/1055-9965.22435174.v1

Supplementary Material from Exploring Differences in the Aspirin–Colorectal Cancer Association by Sex and Race/Ethnicity: The Multiethnic Cohort Study

Autor: Loïc Le Marchand, Christopher A. Haiman, Kristine R. Monroe, Laurence N. Kolonel, Lynne R. Wilkens, Song-Yi Park

Supplementary Table 1. Association between NSAID use and colorectal cancer risk by duration of use and race/ethnicity in the MEC.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24d6dae1b5b61ca02195a8b9f099cf01
https://doi.org/10.1158/1055-9965.22437159.v1