Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Laurence Menard"'
Autor:
Bradley Garman, Can Jiang, Sherif Daouti, Sanah Kumar, Priyanka Mehta, Miye K. Jacques, Laurence Menard, Nataly Manjarrez-Orduno, Sonia Dolfi, Piali Mukherjee, Sharmila Chamling Rai, Ana Lako, Jennifer D. Koenitzer, Justin M. David
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
BackgroundImmune cell expression profiling from patient samples is critical for the successful development of immuno-oncology agents and is useful to understand mechanism-of-action, to identify exploratory biomarkers predictive of response, and to gu
Externí odkaz:
https://doaj.org/article/324c0c0207fc4feeb6f9cf0d6a14e5a6
Autor:
Jeff W. Chen, Jean-Nicolas Schickel, Nikolaos Tsakiris, Joel Sng, Florent Arbogast, Delphine Bouis, Daniele Parisi, Ruchi Gera, Joshua M. Boeckers, Fabien R. Delmotte, Margaret Veselits, Catharina Schuetz, Eva-Maria Jacobsen, Carsten Posovszky, Ansgar S. Schulz, Klaus Schwarz, Marcus R. Clark, Laurence Menard, Eric Meffre
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 2 (2022)
Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of
Externí odkaz:
https://doaj.org/article/e5d69aac33524de49d493bed037a80ad
Autor:
Justin David, Miye Jacques, Bradley Garman, Laurence Menard, Can Jiang, Sherif Daouti, Priyanka Mehta, Mohan Bolisetty, Nataly Manjarrez Orduno
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Externí odkaz:
https://doaj.org/article/cd2b322619b846c38bc2770016928ae2
Autor:
Yu Feng, Liguo Liu, Jing Li, Jia Huang, Jenny Xie, Laurence Menard, Yanfen Shi, Xiaohong Zhao, Shan Xie, Wenjuan Zang, Haidong Tan, Zhiying Yang, Ling Ni
Publikováno v:
Oncology Reports
Hepatocellular carcinoma (HCC) is an immunogenic malignancy, which exhibits low responsiveness to programmed cell death protein-1 (PD-1)/programmed death ligand-1 (PD-L1) antibodies. Therefore, the identification of novel immunotherapeutic targets to
Autor:
Bert van der Vegt, Arjan Vissink, Laurence Menard, Gwenny M Verstappen, Frederik Spijkervet, Yanhua Hu, Julie Carman, Lu Gao, Sarah Pringle, Silvia C Liefers, Vishal Patel, Sumanta Mukherjee, Hendrika Bootsma, Frans G. M. Kroese, Erlin A. Haacke
Publikováno v:
Frontiers in Immunology
Frontiers in Immunology, 12:681941, 1-11. Frontiers Media SA
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology, 12:681941, 1-11. Frontiers Media SA
Frontiers in Immunology, Vol 12 (2021)
BackgroundWhile all salivary glands (SGs) can be involved in primary Sjögren’s syndrome (pSS), their respective role in pathogenesis remains unclear. Our objective was to assess immunopathway activation in paired parotid and labial gland tissue fr
Autor:
Daniele Parisi, Florent Arbogast, Nikolaos Tsakiris, Fabien R. Delmotte, Jean-Nicolas Schickel, Delphine Bouis, Catharina Schuetz, Laurence Menard, Marcus R. Clark, Carsten Posovszky, Ruchi Gera, Eva-Maria Jacobsen, Joshua M Boeckers, Klaus Schwarz, Margaret Veselits, Jeff W. Chen, Ansgar Schulz, Joel Sng, Eric Meffre
Publikováno v:
The Journal of Clinical Investigation
Although negative selection of developing B cells in the periphery is well described, yet poorly understood, evidence of naive B cell positive selection remains elusive. Using 2 humanized mouse models, we demonstrate that there was strong skewing of
Autor:
Bradley Garman, Laurence Menard, Can Jiang, Sherif Daouti, Priyanka Mehta, Miye Jacques, Mohan Bolisetty, Christos Hatzis, Nataly Manjarrez Orduno, Michaela Bowden, Justin David
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 8, Iss Suppl 3 (2020)
Background Characterization of human immune responses by profiling immune cells from patients is critical for the successful development of immuno-oncology agents and is useful to understand mechanism-of-action, identify pharmacodynamic/response biom
Autor:
Jacob Zalaznick, Bogdan Sleczka, Eugene Ciccimaro, Hongwei Zhang, Petia Shipkova, Timothy V Olah, Laurence Menard
Publikováno v:
Bioanalysis. 12(18)
Background: S1PR1, a G protein-coupled receptor (GPCR) protein, is a therapeutic target for treatment of autoimmune diseases. As a potential biomarker for drug effect and patient stratification, it is of great significance to measure it in biological
Autor:
Noah W. Palm, Jennifer H. Anolik, Jason Catanzaro, Jeff W. Chen, Agata A. Bielecka, Haowei Wang, Eric Meffre, Laurence Menard, Tyler Rice, Juliet D. Strauss, Jason M. Bannock
Publikováno v:
Science (New York, N.Y.). 369(6501)
Prenatal antibodies are polyreactive Extensive immunoglobulin gene rearrangements allow humans to recognize a diversity of potential pathogens. This antibody repertoire is more restricted during early life to prevent the generation of autoreactive B
Autor:
Suzanne J. Suchard, Somnath Bandyopadhyay, Sium Habte, Sherif Daouti, Steven G. Nadler, Selena Kansal, Richard Furie, Deborah Lee, Julie Carman, Nataly Manjarrez-Orduño, Francesca Casano, Laurence Menard, Can Jiang, Yanhua Hu
Publikováno v:
ImmunoHorizons. 1:124-132
Systemic lupus erythematosus (SLE) is a highly heterogeneous disease with limited therapeutic options, where clinical manifestations are the result of activation of innate and adaptive immune mechanisms. The elucidation of these mechanisms is critica