Výsledky vyhledávání - "Laurence Maggiorella"

Akademický článek

Oncogenic K-Ras Signals through Epidermal Growth Factor Receptor and Wild-Type H-Ras to Promote Radiation Survival in Pancreatic and Colorectal Carcinoma Cells

Autor: Keith A. Cengel, K. Rahn Voong, Sanjay Chandrasekaran, Laurence Maggiorella, Thomas B. Brunner, Eric Stanbridge, Gary D. Kao, W. Gillies McKenna, Eric J. Bernhard

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 4, Pp 341-348 (2007)

Pancreatic and colorectal carcinomas frequently express oncogenic/mutant K-Ras that contributes to both tumorigenesis and clinically observed resistance to radiation treatment. We have previously shown that farnesyltransferase inhibitors (FTI) radios

Externí odkaz: https://doaj.org/article/f48a0521806f495baa1a5c443b948ea5

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A Disease-Causing Single Amino Acid Deletion in the Coiled-Coil Domain of RAD50 Impairs MRE11 Complex Functions in Yeast and Humans

Autor: Laëtitia Kermasson, Laurence Maggiorella, Marcel Hohl, Mauro Modesti, John H.J. Petrini, Talia Ileri, Jean-Pierre de Villartay, Marie Chansel-Da Cruz, Petr Cejka, Ilaria Ceppi, Patrick Revy

Publikováno v: Cell Reports
Cell Reports, Elsevier Inc, 2020, 33 (13), pp.108559. ⟨10.1016/j.celrep.2020.108559⟩
Cell Reports, 2020, 33 (13), pp.108559. ⟨10.1016/j.celrep.2020.108559⟩
Cell Reports, 33 (13)

Summary The MRE11-RAD50-NBS1 complex plays a central role in response to DNA double-strand breaks. Here, we identify a patient with bone marrow failure and developmental defects caused by biallelic RAD50 mutations. One of the mutations creates a null

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e57ab328d251aa59eb99a76bb2cdac0
https://hal-amu.archives-ouvertes.fr/hal-03438613

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Oncogenic K-Ras signals through epidermal growth factor receptor and wild-type H-Ras to promote radiation survival in pancreatic and colorectal carcinoma cells

Autor: Thomas Brunner, Laurence Maggiorella, K. Rahn Voong, Eric J. Bernhard, Sanjay Chandrasekaran, W. Gillies McKenna, Keith A. Cengel, Gary D. Kao, Eric J. Stanbridge

Publikováno v: Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 4, Pp 341-348 (2007)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fc234d4fff62b89f9e9402b8e7004f1
https://ora.ox.ac.uk/objects/uuid:7e006fb4-b74b-4989-be5d-128e755275de

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Les stratégies nouvelles pour moduler les effets de l'irradiation : exemples d’interactions entre biomodulateurs et radiothérapie

Autor: Laurence Maggiorella, J. H. Bourhis, A. Kaliski, Eric Deutsch

Publikováno v: Cancer/Radiothérapie. 9:69-76

The development of several new anti cancer agents has been made possible because of recent significant achievements in our global understanding of cancer biology. These new "targeted" agents selectively inhibit targets necessary for tumor cell growth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ab413c6f7de6af4562bc26d8c80252c2
https://doi.org/10.1016/j.canrad.2004.12.002

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Tyrphostin AG 1024 modulates radiosensitivity in human breast cancer cells

Autor: Laurence Maggiorella, V Frascona, Elisabetta Marangoni, Eric Deutsch, B Wen, Jean Bourhis, N. Chavaudra, Bassam Abdulkarim

Publikováno v: British Journal of Cancer

Insulin-like growth factor-1 (IGF-1) plays an important growth-promoting effect by activating the PI3K/Akt signalling pathway, inhibiting apoptotic pathways and mediating mitogenic actions. Tyrphostin AG 1024, one selective inhibitor of IGF-1R, was u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0db16dc6a7453a18bc5141c12c9686
http://europepmc.org/articles/PMC2364012

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Fibronectin expression in glioblastomas promotes cell cohesion, collective invasion of basement membrane in vitro and orthotopic tumor growth in mice

Autor: Franck Debarbieux, Geneviève Rougon, Dominique Grall, E Serres, Dominique Figarella-Branger, Thierry Virolle, Fabio Stanchi, Laurent Turchi, Laurence Maggiorella, E Van Obberghen-Schilling, Fanny Burel-Vandenbos

Publikováno v: Oncogene
Oncogene, Nature Publishing Group, 2013, epub ahead of print. ⟨10.1038/onc.2013.305⟩
Oncogene, 2013, epub ahead of print. ⟨10.1038/onc.2013.305⟩

International audience; : Glioblastoma multiforme (GBM) are highly invasive and angiogenic malignancies with a median survival time from diagnosis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ddb51ae9fadee7144c40c873e4733dd
https://hal.archives-ouvertes.fr/hal-00862133

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Nanoscale radiotherapy with hafnium oxide nanoparticles

Autor: Laurence Maggiorella, Jean Bourhis, Laurent Levy, Gilles Barouch, Eric Deutsch, Elsa Borghi, Corinne Devaux, Agnès Pottier

Publikováno v: Future oncology (London, England). 8(9)

Aim: There is considerable interest in approaches that could improve the therapeutic window of radiotherapy. In this study, hafnium oxide nanoparticles were designed that concentrate in tumor cells to achieve intracellular high-energy dose deposit. M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7489ba34fdfb7ff262ebde2d18ca4e12
https://pubmed.ncbi.nlm.nih.gov/23030491

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Cooperative effect of roscovitine and irradiation targets angiogenesis and induces vascular destabilization in human breast carcinoma

Autor: Fabien Milliat, Corinne Aubel, J. H. Bourhis, C. Haton, Paule Opolon, Laurence Maggiorella, E. Connault, Eric Deutsch

Publikováno v: Cell Proliferation
Cell Proliferation, 2009, 42 (1), pp.38-48. ⟨10.1111/j.1365-2184.2008.00570.x⟩

International audience; Angiogenesis is considered as an essential process for tumour development and invasion. Previously, we demonstrated that cyclin-dependent kinase inhibition by roscovitine induces a radiosensitization and a synergistic antitumo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fee22b93ef3c309988166c018835dc2c
https://hal.archives-ouvertes.fr/hal-02985071

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Combined radiation sensitizing and anti-angiogenic effects of ionizing radiation and the protease inhibitor ritonavir in a head and neck carcinoma model

Autor: Laurence, Maggiorella, Bixiu, Wen, Valerie, Frascogna, Paule, Opolon, Jean, Bourhis, Eric, Deutsch

Publikováno v: Anticancer research. 25(6B)

Ritonavir, a protease inhibitor, has been successfully applied in the treatment of HIV infection. Reports of dramatic improvement of AIDS-related cancers, such as primary central system lymphoma after radiation therapy as well as Kaposi's sarcoma, le

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c7f61a2560fd104a1924930b534a1d4e
https://pubmed.ncbi.nlm.nih.gov/16309240

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Angiogenesis and tumor growth inhibition by a matrix metalloproteinase inhibitor targeting radiation-induced invasion

Autor: Laurence Maggiorella, A. Kaliski, Nathalie Lassau, Jean Bourhis, Valérie Rouffiac, Denis Mathé, Paule Opolon, Eric Deutsch, Keith A. Cengel

Publikováno v: Molecular Cancer Therapeutics
Molecular Cancer Therapeutics, American Association for Cancer Research, 2005, 4(11), pp.1717-28

In this study, we have evaluated the interactions between ionizing radiation and a matrix metalloproteinase (MMP) inhibitor. Using Matrigel invasion assays, we show that ionizing radiation induced a dose-dependent increase in the invasive phenotype o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35ef2a649984507c5d22c31058a9fea7
https://hal.archives-ouvertes.fr/hal-00094565

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