Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Laurence M Brill"'
Autor:
Marzia Scortegagna, Hyungsoo Kim, Jian-Liang Li, Hang Yao, Laurence M Brill, Jaeseok Han, Eric Lau, David Bowtell, Gabriel Haddad, Randal J Kaufman, Ze'ev A Ronai
Publikováno v:
PLoS Genetics, Vol 10, Iss 5, p e1004348 (2014)
The endoplasmic reticulum (ER) responds to changes in intracellular homeostasis through activation of the unfolded protein response (UPR). Yet, it is not known how UPR-signaling coordinates adaptation versus cell death. Previous studies suggested tha
Externí odkaz:
https://doaj.org/article/6ddf1d2d0fe64df59b796ae086022ff2
Autor:
April N Meyer, Kristine A Drafahl, Christopher W McAndrew, Jennifer E Gilda, Leandro H Gallo, Martin Haas, Laurence M Brill, Daniel J Donoghue
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e84497 (2013)
Signaling regulated by NFκB and related transcription factors is centrally important to many inflammatory and autoimmune diseases, cancer, and stress responses. The kinase that directly regulates the canonical NFκB transcriptional pathway, Inhibito
Externí odkaz:
https://doaj.org/article/94e790c838bc4b7db7445582e2055c14
Autor:
Juan C. Piña-Crespo, Eliezer Masliah, Tomohiro Nakamura, Olga Prikhodko, Stuart A. Lipton, Chang-ki Oh, Shu-ichi Okamoto, Scott R. McKercher, Laurence M. Brill, Anthony Adame, Nobuki Nakanishi
Publikováno v:
Neurobiol Dis
Neurobiology of Disease, Vol 127, Iss, Pp 390-397 (2019)
Neurobiology of Disease, Vol 127, Iss, Pp 390-397 (2019)
Tuberous sclerosis (TSC) is an autosomal dominant disorder caused by heterozygous mutations in the TSC1 or TSC2 gene. TSC is often associated with neurological, cognitive, and behavioral deficits. TSC patients also express co-morbidity with anxiety a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f096d3e1599cf685a03df3eaf2da95
https://escholarship.org/uc/item/0f96239z
https://escholarship.org/uc/item/0f96239z
Autor:
Brian T. D. Tobe, Alicia M. Winquist, Laurence M. Brill, Gustavo J. Gutierrez, Andrew Crain, Stuart A. Lipton, Junjie Hou, Jennifer Choy, Kutbuddin S. Doctor, Maria Talantova, Evan Y. Snyder, Esther La Monaca, Dieter A. Wolf, Xiayu Huang, David Horn, Ilyas Singec
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 7, Iss 3, Pp 527-542 (2016)
Stem cell reports, vol 7, iss 3
Stem Cell Reports, Vol 7, Iss 3, Pp 527-542 (2016)
Stem cell reports, vol 7, iss 3
Summary Controlled differentiation of human embryonic stem cells (hESCs) can be utilized for precise analysis of cell type identities during early development. We established a highly efficient neural induction strategy and an improved analytical pla
Autor:
Laurence M. Brill, Keith L. Wycoff
Publikováno v:
Molecular Methods in Plant Pathology ISBN: 9780203746523
This chapter reviews advances in the study of plant disease brought about by using monoclonal antibodies raised against fungi. It also reviews the use of monoclonal antibodies in plant disease research. Successful detection and quantitation of fungal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e39001190227feb5afca3ac1fb92cec7
https://doi.org/10.1201/9780203746523-27
https://doi.org/10.1201/9780203746523-27
Autor:
Karen Krchma, Kapil Kapoor, Jian Su Shao, Dwight A. Towler, Bart O. Williams, Abraham Behrmann, Ranjan J. Perera, Carolyn Smith, Attila Kovacs, Su Li Cheng, Megan Mead, Yoanna Bello Arredondo, Bindu Ramachandran, Laurence M. Brill
Publikováno v:
Circulation Research. 117:142-156
Rationale: Wnt signaling regulates key aspects of diabetic vascular disease. Objective: We generated SM22-Cre;LRP6(fl/fl);LDLR −/− mice to determine contributions of Wnt coreceptor low-density lipoprotein receptor–related protein 6 (LRP6) in th
Autor:
Laurence M. Brill, Reinhard Dummer, Adriano Piris, Mitchell P. Levesque, Jennifer A. Wargo, Yardena Samuels, Clemens Krepler, Ally Perlina, Kevin M. Brown, Tongwu Zhang, Ze'ev Ronai, Ruth Halaban, Meenhard Herlyn, Hyungsoo Kim, Nicholas K. Hayward, Zachary A. Cooper, Yongmei Feng, Keith T. Flaherty, Dennie T. Frederick
Publikováno v:
Cell reports
Cell Reports, Vol 11, Iss 9, Pp 1458-1473 (2015)
Cell Reports, Vol 11, Iss 9, Pp 1458-1473 (2015)
SUMMARY Despite the remarkable clinical response of melanoma harboring BRAF mutations to BRAF inhibitors (BRAFi), most tumors become resistant. Here, we identified the downregulation of the ubiquitin ligase RNF125 in BRAFi-resistant melanomas and dem
Autor:
Fumio Nakamura, Husseini K. Manji, Namrata D. Udeshi, Hagop S. Akiskal, Jeffrey H. Price, Nikolaos Venizelos, Wen-Ning Zhao, Cordulla Duerr, Ryan W. Logan, Jeffrey S. Nye, Jasmin Lalonde, Steven D. Sheridan, Joseph T. Coyle, Toshio Ohshima, Yoshio Goshima, Michael McCarthy, Shelley Halpain, Barbara Calabrese, Joshua G. Hunsberger, Martin Alda, Yuuka Inoue, Gustavo J. Gutierrez, Stephen J. Haggarty, Brian T. D. Tobe, Cameron D. Pernia, Richard L. Sidman, Moyuka Wada, Hiroko Makihara, Laurence M. Brill, Glenn T. Konopaske, Yang Liu, De-Maw M. Chuang, Ranor C. B. Basa, Alicia M. Winquist, Yang D. Teng, Michelle M. Sidor, Steven A. Carr, Colleen A. McClung, Guy A. Rouleau, Katsuhiko Mikoshiba, Evan Y. Snyder, Laurel Dorsett, Lina Mastrangelo, Guang Chen, Jianxue Li, Haruko Nakamura, Andrew Crain, Philipp Mertins, Michael G. Brandel, Dongmei Wu, Naoya Yamashita
Publikováno v:
Publikationer från Örebro universitet.
The molecular pathogenesis of bipolar disorder (BPD) is poorly understood. Using human-induced pluripotent stem cells (hiPSCs) to unravel such mechanisms in polygenic diseases is generally challenging. However, hiPSCs from BPD patients responsive to
Autor:
Scott R. McKercher, Nobuki Nakanishi, Mohd Waseem Akhtar, Stuart A. Lipton, Laurence M. Brill, Shing Fai Chan, Shu-ichi Okamoto, Rameez Zaidi, Samuel Sances
Publikováno v:
The Journal of Neuroscience. 34:4640-4653
Mutations in the ataxia telangiectasia mutated (ATM) gene, which encodes a kinase critical for the normal DNA damage response, cause the neurodegenerative disorder ataxia-telangiectasia (AT). The substrates of ATM in the brain are poorly understood.
Autor:
Gustavo J. Gutierrez, Shannon McLaughlan, Pedro Aza-Blanc, Tal Varsano, Yongmei Feng, Nahum Sonenberg, Valentina Gandin, Tiago Ferreira, Qingyan Au, Ivan Topisirovic, Tommy Alain, Ze'ev Ronai, Laurence M. Brill
Publikováno v:
Molecular and Cellular Biology. 33:2510-2526
Folding of newly synthesized polypeptides (NSPs) into functional proteins is a highly regulated process. Rigorous quality control ensures that NSPs attain their native fold during or shortly after completion of translation. Nonetheless, signaling pat