Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Laurence Lesueur"'
Autor:
Dennis Bigg, José Camara, Laurence Lesueur-Ginot, Hélène Coulomb, Philip G. Kasprzyk, Danièle Demarquay, Marion Huchet, Olivier Lavergne, Gregoire Prevost
Publikováno v:
Cancer Research. 64:4942-4949
BN80927 belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered β-hydroxylactone ring. Preclinical data reported here show
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::503adab5a27c3987410b3a0e91a21700
https://doi.org/10.1158/0008-5472.can-03-3872
https://doi.org/10.1158/0008-5472.can-03-3872
Autor:
José Camara, Laurence Lesueur-Ginot, Christian Bailly, Hélène Coulomb, Marion Huchet, Danièle Demarquay, Dennis Bigg, Olivier Lavergne, Philip G. Kasprzyk
Publikováno v:
Anti-Cancer Drugs. 12:9-19
BN 80915, a lead compound of the homocamptothecin (hCPT) family, has entered clinical trials. BN 80915 is a difluoro-hCPT where the six-membered a-hydroxylactone ring of camptothecin (CPT) is replaced by a seven-membered b-hydroxylactone ring. Precli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a91118914428641bbd02e097e292545
https://doi.org/10.1097/00001813-200101000-00003
https://doi.org/10.1097/00001813-200101000-00003
Autor:
Olivier Lavergne, Alain Rolland, Christophe Lanco, Laurence Lesueur-Ginot, Marion Huchet, Dennis Bigg, Danièle Demarquay, Hélène Coulomb, Jeremiah Harnett
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 9:2599-2602
BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::509d0222579727f64bca61d8645c5fc3
https://doi.org/10.1016/s0960-894x(99)00428-x
https://doi.org/10.1016/s0960-894x(99)00428-x
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2235-2238
The crucial E-ring of camptothecin has been modified to afford the homologous β-hydroxylactone derivative BN 80245. This compound, which is more stable than camptothecin, remains a potent inhibitor of both cell growth and topoisomerase I.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::34b0331733e1db17b65f6b0b2a5fc072
https://doi.org/10.1016/s0960-894x(97)00398-3
https://doi.org/10.1016/s0960-894x(97)00398-3
Autor:
François Schächter, Philippe Froguel, Laurence Faure-Delanef, Laurence Lesueur-Ginot, Hervé Rouger, Daniel Cohen, Frédérique Guénot
Publikováno v:
Nature Genetics. 6:29-32
In an effort to dissect the genetic components of longevity, we have undertaken case-control studies of populations of centenarians (n = 338) and adults aged 20-70 years at several polymorphic candidate gene loci. Here we report results on two genes,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3960d7ddda9164ec52fecac8319cd8d0
https://doi.org/10.1038/ng0194-29
https://doi.org/10.1038/ng0194-29
Publikováno v:
ChemInform. 28
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ea46bde02369b94b3f003552a24cc00a
https://doi.org/10.1002/chin.199752240
https://doi.org/10.1002/chin.199752240
Autor:
Alain Rolland, Christophe Lanco, Olivier Lavergne, Marion Huchet, Hélène Coulomb, Dennis Bigg, Laurence Lesueur-Ginot, Danièle Demarquay, Jeremiah Harnett
Publikováno v:
ChemInform. 30
BN 80927, a novel homocamptothecin derivative, inhibits both topoisomerase I and topoisomerase II mediated DNA relaxation and shows pronounced cytotoxicity against HT29, SKOV-3, DU145 and MCF7 human tumor cell lines.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3ac45dad2ceaf2e3351f53a6082eae9
https://doi.org/10.1002/chin.199949194
https://doi.org/10.1002/chin.199949194
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1991, 88 (3), pp.824-828
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1991, 88 (3), pp.824-828
The biological activities of long and short forms of the prolactin receptor have been compared. These two receptors expressed in mammalian cells were shown to bind prolactin with equal high affinity. The ability of these different forms to transduce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f98ee82247e696271064489b5f0ba53
https://doi.org/10.1073/pnas.88.3.824
https://doi.org/10.1073/pnas.88.3.824
Autor:
Laurence, Lesueur, Jean-Louis, Arne
Publikováno v:
La Revue du praticien. 57(18)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4c1a34cfd14fafc8d175e47d139acb1f
https://pubmed.ncbi.nlm.nih.gov/18389555
https://pubmed.ncbi.nlm.nih.gov/18389555
Autor:
Danièle, Demarquay, Marion, Huchet, Helène, Coulomb, Laurence, Lesueur-Ginot, Olivier, Lavergne, José, Camara, Philip G, Kasprzyk, Grégoire, Prévost, Dennis C H, Bigg
Publikováno v:
Cancer research. 64(14)
BN80927 belongs to a novel family of camptothecin analogs, the homocamptothecins, developed on the concept of topoisomerase I (Topo I) inhibition and characterized by a stable seven-membered beta-hydroxylactone ring. Preclinical data reported here sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::62a098ada186a8b6157c1bdda2bf5c07
https://pubmed.ncbi.nlm.nih.gov/15256467
https://pubmed.ncbi.nlm.nih.gov/15256467