Zobrazeno 1 - 10
of 121
pro vyhledávání: '"Laurence Lafanechère"'
Autor:
Alaa Al Assi, Solène Posty, Frédéric Lamarche, Amel Chebel, Jérôme Guitton, Cécile Cottet-Rousselle, Renaud Prudent, Laurence Lafanechère, Stéphane Giraud, Patrick Dallemagne, Peggy Suzanne, Aurélie Verney, Laurent Genestier, Marie Castets, Eric Fontaine, Marc Billaud, Martine Cordier-Bussat
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-14 (2024)
Abstract Cancer cells are highly dependent on bioenergetic processes to support their growth and survival. Disruption of metabolic pathways, particularly by targeting the mitochondrial electron transport chain complexes (ETC-I to V) has become an att
Externí odkaz:
https://doaj.org/article/3280099ad7854690b1351796393f9c52
Autor:
Cécile Letulle, François-Xavier Toublet, Aline Pinon, Soufyane Hba, Aurélie Laurent, Vincent Sol, Catherine Fagnère, Benjamin Rioux, Florent Allais, Sophie Michallet, Laurence Lafanechère, Youness Limami, Mounia Oudghiri, Mohamed Othman, Adam Daïch, Bertrand Liagre, Ata Martin Lawson, Christelle Pouget
Publikováno v:
Pharmaceuticals, Vol 17, Iss 9, p 1207 (2024)
In the context of designing innovative anticancer agents, the synthesis of a series of chalcones bearing a 3,4,5-trimethoxylated A ring and a variety of B rings, including phenols and original heterocycles such as chromones, was conducted. For this e
Externí odkaz:
https://doaj.org/article/bcc1be4f4ae54c15861b7cb9f5906914
Autor:
Laurence Lafanechère
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Compounds targeting microtubules are widely used in cancer therapy with a proven efficacy. However, because they also target non-cancerous cells, their administration leads to numerous adverse effects. With the advancement of knowledge on the structu
Externí odkaz:
https://doaj.org/article/01451f6e5b534777bfff07ea2dba5281
Autor:
Anne-Sophie Ribba, Morgane Batzenschlager, Clotilde Rabat, Thierry Buchou, Sylvie Moog, Saadi Khochbin, Ekaterina Bourova-Flin, Laurence Lafanechère, François Lanza, Karin Sadoul
Publikováno v:
Platelets, Vol 32, Iss 4, Pp 568-572 (2021)
The discoid shape of resting platelets is maintained by a peripheral, circular bundle of microtubules called marginal band. Marginal band microtubules are acetylated on lysine 40 of the alpha-tubulin subunits. We have previously shown that the deacet
Externí odkaz:
https://doaj.org/article/7ca4772011f947889cf80c1268389000
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3592 (2023)
Radiation resistance and radiation-related side effects warrant research into alternative strategies in the application of this modality to cancer treatment. Designed in silico to improve the pharmacokinetics and anti-cancer properties of 2-methoxyes
Externí odkaz:
https://doaj.org/article/db1402002e694f6c83451e94eca6adf1
Publikováno v:
Platelets, Vol 31, Iss 5, Pp 551-558 (2020)
Although live imaging of dynamic processes in platelets is a challenging task, several important observations have been published during the last 20 years. We will discuss the amazing insights that have been achieved, the difficulties that can be enc
Externí odkaz:
https://doaj.org/article/d7c9a2d5514545248932a21cd9cdbb4f
Autor:
Sylvie Gory-Fauré, Rebecca Powell, Julie Jonckheere, Fabien Lanté, Eric Denarier, Leticia Peris, Chi Hung Nguyen, Alain Buisson, Laurence Lafanechère, Annie Andrieux
Publikováno v:
Frontiers in Pharmacology, Vol 12 (2021)
The search for effective treatments for neuropsychiatric disorders is ongoing, with progress being made as brain structure and neuronal function become clearer. The central roles played by microtubules (MT) and actin in synaptic transmission and plas
Externí odkaz:
https://doaj.org/article/c1a192c89d934d5a9b191202b317f1b4
Autor:
Sacnite Ramirez Rios, Anaelle Torres, Hélène Diemer, Véronique Collin-Faure, Sarah Cianférani, Laurence Lafanechère, Thierry Rabilloud
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0252450 (2021)
Except cells circulating in the bloodstream, most cells in vertebrates are adherent. Studying the repercussions of adherence per se in cell physiology is thus very difficult to carry out, although it plays an important role in cancer biology, e.g. in
Externí odkaz:
https://doaj.org/article/d63958df8ca14344aa756ed03b7a7839
Autor:
Sacnicte Ramirez-Rios, Sophie Michallet, Leticia Peris, Caroline Barette, Clotilde Rabat, Yangbo Feng, Marie-Odile Fauvarque, Annie Andrieux, Karin Sadoul, Laurence Lafanechère
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect. However the detection of a stabilized microtubule network needs specific assays sin
Externí odkaz:
https://doaj.org/article/adc39229977a4d7ebef42931cfe2c180
Publikováno v:
Cells, Vol 11, Iss 3, p 403 (2022)
The organization of cell populations within animal tissues is essential for the morphogenesis of organs during development. Cells recognize three-dimensional positions with respect to the whole organism and regulate their cell shape, motility, migrat
Externí odkaz:
https://doaj.org/article/efac612f5b2349469a8d1a01bfd709e5