Zobrazeno 1 - 10
of 45
pro vyhledávání: '"Laurence J. King"'
Autor:
Michael N. Clifford, Laurence J. King, Asimina Kerimi, Maria Gema Pereira-Caro, Gary Williamson
Publikováno v:
Critical Reviews in Food Science and Nutrition. :1-58
ω-Phenyl-alkenoic acids are abundant in coffee, fruits, and vegetables. Along with ω-phenyl-alkanoic acids, they are produced from numerous dietary (poly)phenols and aromatic amino acids in vivo. This review addresses how phenyl-ring substitution a
Autor:
Marian S. Faughnan, Brian Wolfe, Linda Zimmer-Nechemias, Laurence J. King, Anne Hawdon, Aedin Cassidy, Jonathan E. Brown, Kenneth D.R. Setchell, Joe Millward
Publikováno v:
The Journal of Nutrition. 136:45-51
The precise role that isoflavones play in the health-related effects of soy foods, and their potential for adverse effects are controversial. This may be due in part to a lack of basic knowledge regarding their bioavailability and metabolism, particu
Publikováno v:
Toxicology and Applied Pharmacology. 143:420-428
The reductive metabolic activation of 1,1-dichloro-2,2,2-trifluoroethane (HCFC-123), one of the potential substitutes for the ozone-depleting chlorofluorocarbons and a close structural analogue of the hepatotoxic anesthetic halothane, was investigate
Publikováno v:
Chemical Research in Toxicology, 9, 1092-1102. American Chemical Society
Commandeur, J N M, King, L J, Koymans, L & Vermeulen, N P E 1996, ' Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates. ', Chemical Research in Toxicology, vol. 9, pp. 1092-1102 . https://doi.org/10.1021/tx960049b
Commandeur, J N M, King, L J, Koymans, L & Vermeulen, N P E 1996, ' Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: Indications for formation of both thionoacylating species and thiiranes as reactive intermediates. ', Chemical Research in Toxicology, vol. 9, pp. 1092-1102 . https://doi.org/10.1021/tx960049b
The covalent binding of reactive intermediates, formed by beta-elimination of cysteine S-conjugates of halogenated alkenes, to nucleophiles was studied using 19F-NMR and GC-MS analysis. beta-Elimination reactions were performed using rat renal cytoso
Autor:
Florian Viton, Stavroula Stoupi, Jonathan E. Brown, Laurence J. King, Michael N. Clifford, Gary Williamson, Denis Barron
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 38(2)
Procyanidins are important biologically active compounds, but the pathway and extent of absorption and metabolism are controversial. We conducted a mass balance study to evaluate the total radioactivity excreted in urine and feces after oral administ
Autor:
A. M. Symons, Laurence J. King
Publikováno v:
Inflammopharmacology. 11(1)
Inflammation may ultimately result from damage to membrane lipids by reactive oxygen species (ROS) such as peroxide, superoxide anion, hydroxyl radical and singlet oxygen. This study compares some of the methods used to determine ROS—ethane exhalat
Objective: Our purpose was to investigate iron status parameters in preeclampsia with a view to exploring their possible contribution to the etiology. Study Design: In prepared serum samples from 40 preeclamptic women and matched pregnant control sub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcbe9b7a0d12ba8b37836f3f0edc2668
https://surrey.eprints-hosting.org/185979/
https://surrey.eprints-hosting.org/185979/
Autor:
Laurence Howells, Claudia Langlais, David D Macpherson, Laurence J King, Maurice J. Sauer, A. Santi, Nick G. Coldham, Clara Montesissa
Publikováno v:
The Journal of steroid biochemistry and molecular biology. 70(4-6)
Biotransformation of the phytoestrogen [14C]genistein was investigated in male and female rats by application of narrow-bore radio-HPLC-MSn (LCQ, Finnigan) to determine intermediates in metabolism. Urine contained five metabolites, Gm1-Gm5, 24 h afte
Autor:
J. Barril-Antuña, Maurizio Manno, Lionel Gil, J.S.L. Fowler, O. Torres-Alanı́s, Fernando Díaz-Barriga, Patricia Ostrosky-Wegman, R.I. Patño, Arnulfo Albores, Wolfgang Dekant, F. De Matteis, Mariano E. Cebrián, Laurence J. King, G. Olarte, Fernando Jaramillo-Juárez
Publikováno v:
Repositorio U. El Bosque
Universidad El Bosque
instacron:Universidad El Bosque
Universidad El Bosque
instacron:Universidad El Bosque
Industrial development has resulted in an increased release of chemicals and other agents into the environment, resulting in damage to the environment as well as increasing the risk of adverse effects on human health. Environmental toxicology (ET) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26ecb3fe7689a07c717751c6e8b6a446
Publikováno v:
Archives of Toxicology. 64:511-513
Study of influence of ketonazole ou cyclosporin blood concentrations after it had reached steady-state levels in rats. The possibilities that the site of interaction is during metabolism or during absorption were investigated