Výsledky vyhledávání - "Laurence J. Hurley"

Abstract 2967: Activity of G-quadruplex stabilizing small molecule that downregulates MYC and synergizes with Navitoclax in acute myeloid leukemia cells

Autor: Justin J. Montoya, Megan A. Turnidge, Daniel H. Wai, David W. Lee, Apruvi Patel, Vijay Gokhale, Laurence J. Hurley, David O. Azorsa

Publikováno v: Cancer Research. 79:2967-2967

Acute Myeloid Leukemia (AML) is a malignancy of myeloid precursor cells that can occur when genomic changes alter expression of key genes, causing cells to resume an undifferentiated state and proliferate. Ongoing efforts have focused on developing t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ce3c0b31b360362c54018472e7c37b08
https://doi.org/10.1158/1538-7445.am2019-2967

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Abstract B24: Targeting promoter regions of oncogenic drivers in pediatric AML cells using G-quadruplex Interacting Drugs (GQIDs)

Autor: Justin J. Montoya, Daniel H. Wai, Robert J. Arceci, David W. Lee, Apurvi Patel, David O. Azorsa, Laurence J. Hurley, Marya S. Sabir, Megan A. Turnidge, Eiman Aleem, Vijay Gokhale

Publikováno v: Cancer Research. 76:B24-B24

Cancer is primarily a disease characterized by aberrant gene expression that is manifested by the overexpression of key genes that support tumor development and maintenance. In many instances, oncogenic drivers are frequently ‘undruggable’ becaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d48099dd920caf9d7553dc61bbab62fa
https://doi.org/10.1158/1538-7445.pedca15-b24

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