Zobrazeno 1 - 10
of 183
pro vyhledávání: '"Laurence J Marton"'
Autor:
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Publikováno v:
PLoS ONE, Vol 12, Iss 5, p e0178102 (2017)
[This corrects the article DOI: 10.1371/journal.pone.0175917.].
Externí odkaz:
https://doaj.org/article/0d46307286994a9b96a2e3ed61ba3387
Autor:
Tracy Murray-Stewart, Elena Ferrari, Ying Xie, Fei Yu, Laurence J Marton, David Oupicky, Robert A Casero
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0175917 (2017)
Synthesizing polycationic polymers directly from existing drugs overcomes the drug-loading limitations often associated with pharmacologically inert nanocarriers. We recently described nanocarriers formed from a first-generation polyamine analogue, b
Externí odkaz:
https://doaj.org/article/bb99cdd867ba49acb4ce1c6c0927efe0
Autor:
Robert A. Casero, Laurence J. Marton, Patrick M. Woster, Christin L. Hanigan, Tracy Murray-Stewart
PDF file, 87K, Figure S1. Chemical structures of the natural polyamine spermine and the spermine analogues PG-11047 and BENSpm. Figure S2. Effects of treatment with PG-11047, BENSpm, and MS-275 on chromatin acetylation status. (A) Promoter region occ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c20f3bd3f9285eca58802c97f76490d
https://doi.org/10.1158/1535-7163.22497417.v1
https://doi.org/10.1158/1535-7163.22497417.v1
Autor:
Robert A. Casero, Laurence J. Marton, Patrick M. Woster, Christin L. Hanigan, Tracy Murray-Stewart
The treatment of specific tumor cell lines with poly- and oligoamine analogs results in a superinduction of polyamine catabolism that is associated with cytotoxicity; however, other tumor cells show resistance to analog treatment. Recent data indicat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba0267cf5856ca7baf2d5cedb3aa1cf
https://doi.org/10.1158/1535-7163.c.6535608.v1
https://doi.org/10.1158/1535-7163.c.6535608.v1
Autor:
Robert A. Casero, Patrick M. Woster, Richard J. Jones, Brandy Perkins, Laurence J. Marton, Stephen B. Baylin, Yu Wu, Tracy Murray Stewart, Yi Huang
CCR Translation for the Article from Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520d9423f442a140ed86d07d2cb0d7ec
https://doi.org/10.1158/1078-0432.22439985
https://doi.org/10.1158/1078-0432.22439985
Autor:
Robert A. Casero, Patrick M. Woster, Richard J. Jones, Brandy Perkins, Laurence J. Marton, Stephen B. Baylin, Yu Wu, Tracy Murray Stewart, Yi Huang
Supplementary Data from Novel Oligoamine Analogues Inhibit Lysine-Specific Demethylase 1 and Induce Reexpression of Epigenetically Silenced Genes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::126b6a7be80754b24afc2a245b2fe76f
https://doi.org/10.1158/1078-0432.22439982
https://doi.org/10.1158/1078-0432.22439982
Autor:
Robert A. Casero, Patrick M. Woster, Richard J. Jones, Brandy Perkins, Laurence J. Marton, Stephen B. Baylin, Yu Wu, Tracy Murray Stewart, Yi Huang
Purpose: Abnormal DNA CpG island hypermethylation and transcriptionally repressive histone modifications are associated with the aberrant silencing of tumor suppressor genes. Lysine methylation is a dynamic, enzymatically controlled process. Lysine-s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34d612b28d495f07f1aae76c07a4f3ec
https://doi.org/10.1158/1078-0432.c.6517362.v1
https://doi.org/10.1158/1078-0432.c.6517362.v1
Autor:
John L. Cleveland, Laurence J. Marton, Robert A. Casero, Janet A. Houghton, Andrew Goodwin, Jerold E. Rehg, Dorothy Bush, Venudhar K. Reddy, Steffan T. Nawrocki, Jennifer S. Carew
Supplementary Methods and Figure 1 from The Novel Polyamine Analogue CGC-11093 Enhances the Antimyeloma Activity of Bortezomib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd8460dc97a3713f6aeaa6e9a1e6323
https://doi.org/10.1158/0008-5472.22375283
https://doi.org/10.1158/0008-5472.22375283
Autor:
John L. Cleveland, Laurence J. Marton, Robert A. Casero, Janet A. Houghton, Andrew Goodwin, Jerold E. Rehg, Dorothy Bush, Venudhar K. Reddy, Steffan T. Nawrocki, Jennifer S. Carew
Multiple myeloma (MM) is an incurable plasma cell malignancy. The recent successes of the proteasome inhibitor bortezomib in MM therapy have prompted investigations of its efficacy in combination with other anticancer agents. Polyamines play importan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12bffe127ebb916d8b031116f9e5b864
https://doi.org/10.1158/0008-5472.c.6497762
https://doi.org/10.1158/0008-5472.c.6497762
Autor:
Carlos Becerra, Donald A. Richards, Thomas E. Boyd, Paul Conkling, Hillary H. Wu, Tracy Murray Stewart, Joe Stephenson, Daniel D. Von Hoff, Nicholas J. Vogelzang, Robert A. Casero, Lawrence Garbo, David Smith, Michael L. Fitzgerald, Robert M. Jotte, Laurence J. Marton
Publikováno v:
Cancer Chemother Pharmacol
PURPOSE: Polyamines are absolutely essential for maintaining tumor cell proliferation. PG-11047, a polyamine analogue, is a nonfunctional competitor of the natural polyamine spermine that has demonstrated anticancer activity in cells and animal model
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07dc2814931dcb5a17c92aa4a2ab11fb
https://doi.org/10.1007/s00280-020-04201-1
https://doi.org/10.1007/s00280-020-04201-1