Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Laurence H. Patterson"'
Autor:
Daniela Presa, Syed A. Khurram, Amir Z. A. Zubir, Sneha Smarakan, Patricia A. Cooper, Goreti R. Morais, Maria Sadiq, Mark Sutherland, Paul M. Loadman, James McCaul, Steven D. Shnyder, Laurence H. Patterson, Klaus Pors
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract Epidemiological studies have shown that head and neck cancer (HNC) is a complex multistage process that in part involves exposure to a combination of carcinogens and the capacity of certain drug-metabolising enzymes including cytochrome P450
Externí odkaz:
https://doaj.org/article/4ea9b86b01fd4ec18d301c0d665c1e69
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 107K, In vivo metabolic profile of tumour and liver after administration of ICT2700 to CYP1A1 tumor-bearing mice
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53fa7a3eeadf697425f73382b1b2ff93
https://doi.org/10.1158/1535-7163.22499368.v1
https://doi.org/10.1158/1535-7163.22499368.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
We identify cytochrome P450 1A1 (CYP1A1) as a target for tumor-selective drug development in bladder cancer and describe the characterization of ICT2700, designed to be metabolized from a prodrug to a potent cytotoxin selectively by CYP1A1. Elevated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e7d993df8c3092c76202f58dfbcd09
https://doi.org/10.1158/1535-7163.c.6536128.v1
https://doi.org/10.1158/1535-7163.c.6536128.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 120K, Representative CYP1A1 activity of the EJ138 bladder cell line and EJ138-1A1 bladder cell line, determined by measurement of Ethoxyresorufin O-de-ethylation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d566ccd99f7fb819d8b39d53982cf80
https://doi.org/10.1158/1535-7163.22499371.v1
https://doi.org/10.1158/1535-7163.22499371.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 109K, Methodology for analysis of CYP1 gene and protein expression,Detection of DNA-damage induced gamma-H2AX protein expression, and analysis of ICT2700 metabolism in mouse and human liver ex vivo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520a633e7c506912b1f2b1a15a04c4c2
https://doi.org/10.1158/1535-7163.22499362
https://doi.org/10.1158/1535-7163.22499362
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 52K, Lack of CYP1 induction by the chloromethylpyrroloindoline ICT2700
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a05076c72e09564975269b0cf51d4414
https://doi.org/10.1158/1535-7163.22499356.v1
https://doi.org/10.1158/1535-7163.22499356.v1
Autor:
Laurence H. Patterson, Steve D. Shnyder, Klaus Pors, Mark Searcey, Patricia A. Cooper, Mohammed N. Alandas, Nicola A. Illingworth, Helen M. Sheldrake, Jonathan P. Laye, Paul M. Loadman, Jason H. Gill, Mark Sutherland
PDF file - 85k, Expression of CYP1A1 protein in human transitional cell carcinoma (TCC) of the bladder by immunohistochemical analyses.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15d0a32d12084077e7d0db0a60ef4948
https://doi.org/10.1158/1535-7163.22499359.v1
https://doi.org/10.1158/1535-7163.22499359.v1
Autor:
Declan J. McKenna, Stephanie R. McKeown, Paul J. Smith, Laurence H. Patterson, Rachel J. Errington, Jenny Worthington, Louise Ming, S. Nicole Williams, Niall M. Byrne, Heather Nesbitt
Purpose: To understand the role of hypoxia in prostate tumor progression and to evaluate the ability of the novel unidirectional hypoxia-activated prodrug OCT1002 to enhance the antitumor effect of bicalutamide.Experimental Design: The effect of OCT1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36c0ea6dd16f9a923565737e218b3f4a
https://doi.org/10.1158/1078-0432.c.6525969
https://doi.org/10.1158/1078-0432.c.6525969
Autor:
Magnus Ingelman-Sundberg, Laurence H. Patterson, Souren Mkrtchian, Helen M. Sheldrake, Mohammed N. Alandas, Inger Johansson, Steven D. Shnyder, Paul M. Loadman, Klaus Pors, Sandra Travica
Supplementary Figure 1 - PDF file 89K, Structures of the compounds used in the study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16c088849684e08114fd574e4d0b4548
https://doi.org/10.1158/1078-0432.22450713
https://doi.org/10.1158/1078-0432.22450713
Autor:
Magnus Ingelman-Sundberg, Laurence H. Patterson, Souren Mkrtchian, Helen M. Sheldrake, Mohammed N. Alandas, Inger Johansson, Steven D. Shnyder, Paul M. Loadman, Klaus Pors, Sandra Travica
Supplementary Table 1 - PDF file 24K, Pharmacokinetic data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4120cf5b2d2fe9b815cb9702b45981bd
https://doi.org/10.1158/1078-0432.22450707.v1
https://doi.org/10.1158/1078-0432.22450707.v1