Výsledky vyhledávání - "Laurence F. Morton"

The Collagen-binding A-domains of Integrins α1β1 and α2β1Recognize the Same Specific Amino Acid Sequence, GFOGER, in Native (Triple-helical) Collagens

Autor: Anthony R. Peachey, C. Graham Knight, Michael J. Barnes, Danny S. Tuckwell, Richard W. Farndale, Laurence F. Morton

Publikováno v: Journal of Biological Chemistry. 275:35-40

We have previously assigned an integrin alpha(2)beta(1)-recognition site in collagen I to the sequence, GFOGERGVEGPOGPA (O = Hyp), corresponding to residues 502-516 of the alpha(1)(I) chain and located in the fragment alpha(1)(I)CB3 (Knight, C. G., M

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b34231ba86d8cf04aad4131ca929a972
https://doi.org/10.1074/jbc.275.1.35

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Adhesive Domains in the Collagen III Fragment α1(III)CB4 that Support α2β1- and von Willebrand Factor-mediated Platelet Adhesion under Flow Conditions

Autor: C.G. Knight, Verkleij Mw, M. J. W. Ijsseldijk, G.J. Heijnen-Snyder, Laurence F. Morton, J. J. Sixma, de Groot Pg, Huizinga Eg, Mike Barnes

Publikováno v: Thrombosis and Haemostasis. 82:1137-1144

Seven overlapping peptides derived from the bovine alpha1(III)CB4 fragment of collagen III support static platelet adhesion, and an integrin alpha2beta1-recognition site has been assigned within this fragment to residues 522-528 of the collagen alpha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ddb7ba6131c12ddcc191919f7b793e12
https://doi.org/10.1055/s-0037-1614343

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Identification in Collagen Type I of an Integrin α2β1-binding Site Containing an Essential GER Sequence

Autor: C. Graham Knight, Laurence F. Morton, Anthony R. Peachey, David J. Onley, Peter A. Smethurst, Richard W. Farndale, Michael J. Barnes, Danny S. Tuckwell, Anthea J. Messent

Publikováno v: Journal of Biological Chemistry. 273:33287-33294

The collagen type I-derived fragment alpha1(I)CB3 is known to recognize the platelet collagen receptor integrin alpha2beta1 as effectively as the parent collagen, although it lacks platelet-aggregatory activity. We have synthesized the fragment as se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d296080f56458e8585ef87173ba3640
https://doi.org/10.1074/jbc.273.50.33287

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Simple Collagen-Like Peptides Support Platelet Adhesion Under Static But Not Under Flow Conditions: Interaction Via α2β1 and von Willebrand Factor With Specific Sequences in Native Collagen Is a Requirement to Resist Shear Forces

Autor: Michael J. Barnes, Marilyn W. Verkleij, Philip G. de Groot, Laurence F. Morton, Jan J. Sixma, C. Graham Knight

Publikováno v: Blood. 91:3808-3816

The aim of this study was to define the need for specific collagen sequences and the role of their conformation in platelet adhesion to collagen under both static and flow conditions. We recently reported that simple triple-helical collagen-related p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d049fa0ba36e6be6bdf6f16cde2e30d
https://doi.org/10.1182/blood.v91.10.3808.3808_3808_3816

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The Platelet Reactivity of Synthetic Peptides Based on the Collagen III Fragment α1(III)CB4

Autor: Anthony R. Peachey, Laurence F. Morton, Mike Barnes, Richard W. Farndale, C. Graham Knight

Publikováno v: Journal of Biological Chemistry. 272:11044-11048

The platelet-reactive collagen III-derived fragment alpha1(III)CB4 has been synthesized as seven overlapping peptides, each as a homotrimeric triple-helical species covalently linked at the C terminus. Additional Gly-Pro-Hyp triplets were introduced

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::95e07d8e531905255359f210edcea815
https://doi.org/10.1074/jbc.272.17.11044

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A Collagen-Like Peptide Stimulates Tyrosine Phosphorylation of syk and Phospholipase Cγ2 in Platelets Independent of the Integrin α2β1

Autor: Marcus Achison, Laurence F. Morton, Mike Barnes, Young Han Lee, Richard W. Farndale, Steve P. Watson, J. Asselin, Jonathan M. Gibbins

Publikováno v: Blood. 89:1235-1242

Activation of platelets by collagen is mediated through a tyrosine kinase-dependent pathway that is associated with phosphorylation of the Fc receptor gamma chain, the tyrosine kinase syk, and phospholipase C gamma2 (PLC gamma2). We recently describe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::56ce4ee36a93029242c9986102aa7133
https://doi.org/10.1182/blood.v89.4.1235

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Integrin α2β1-independent activation of platelets by simple collagen-like peptides: collagen tertiary (triple-helical) and quaternary (polymeric) structures are sufficient alone for α2β1-independent platelet reactivity

Autor: R D Young, Laurence F. Morton, Michael J. Barnes, Richard W. Farndale, Philip G. Hargreaves

Publikováno v: Biochemical Journal. 306:337-344

The platelet reactivities of two simple collagen-like synthetic peptides, Gly-Lys-Hyp-(Gly-Pro-Hyp)10-Gly-Lys-Hyp-Gly and Gly-Cys-Hyp-(Gly-Pro-Hyp)10-Gly-Cys-Hyp-Gly, were investigated. Both peptides adopted a stable triple-helical conformation in so

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a935040b5a71f2048a9301b34ed35352
https://doi.org/10.1042/bj3060337

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Collagen-platelet interaction: Gly-Pro-Hyp is uniquely specific for platelet Gp VI and mediates platelet activation by collagen

Autor: David J. Onley, C.G. Knight, Tatsuo Ichinohe, Laurence F. Morton, Michael J. Barnes, Richard W. Farndale, Minoru Okuma, Anthony R. Peachey

Publikováno v: Cardiovascular research. 41(2)

Peptides consisting of a repeat Gly-Pro-Hyp sequence are potent platelet agonists. The aim of this study was: (1) to examine the specificity of this sequence for platelet activation; (2) to confirm its recognition by platelet glycoprotein VI; and (3)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4211fe1aea8654df787c5268a8dd556
https://pubmed.ncbi.nlm.nih.gov/10341844

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Role for p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue

Autor: Lesley Rawlinson, Richard W. Farndale, Mike Barnes, Laurence F. Morton, John C. Lee, R J Waller, Simon Sarsfield, J Saklatvala

Publikováno v: The Journal of biological chemistry. 271(12)

p38 mitogen-activated protein kinase (MAPK) was identified in platelets on the basis of (a) its reactivity with antibodies to C-terminal and N-terminal peptides, and (b) its ability to activate MAPK-activated protein kinase-2, which phosphorylates th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::795fbda774e03a22aa6922a90b6d2bf3
https://pubmed.ncbi.nlm.nih.gov/8636072

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Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I

Autor: Michael J. Barnes, Martin J. Humphries, Lynn S. Zijenah, Laurence F. Morton, A H Goodall, Anthony R. Peachey

Publikováno v: Europe PubMed Central

Platelet adhesion has been measured to type-I monomeric collagen, collagen fibres, alpha 1(I) and alpha 2(I) chains and the chain fragments alpha 1(I)CB3, alpha 1(I)CB6, alpha 1(I)CB7 and alpha 1(I)CB8, and alpha 2(I)CB3,5 and alpha 2(I)CB4. Little i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39454575806e88303daf96ea333d3aa4
https://pubmed.ncbi.nlm.nih.gov/7514871

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