Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laurence Dube"'
Autor:
Jillian Drage, Jalaj Arora, Nancy Barriault, Jack Peragine, Ian Egle, Michel Bordeleau, Keith Jarvie, Lucy Mazzocco, Laurence Dube, Ashok Tehim
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 14:4847-4850
A series of N-(1-benzylpyrrolidin-3-yl)arylbenzamides 8 has been prepared, and their structure-activity relationships studied. Potent ligands selective for human D(4) (hD(4)) over hD(2) and alpha(1) have been identified. One example was determined to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::773535cb6f2b81e6a6f0176314f61727
https://doi.org/10.1016/j.bmcl.2004.07.045
https://doi.org/10.1016/j.bmcl.2004.07.045
Autor:
Glenn Goodwin, Christian Ryckeley, Davide Fox, Michael Ashley, Laurence Dubensky, Mauricio Danckers, Todd Slesinger
Publikováno v:
Interactive Journal of Medical Research, Vol 12, p e43295 (2023)
Scleroderma is a group of autoimmune diseases that principally affects the skin, blood vessels, muscles, and viscera. One of the more well-known subgroups of scleroderma is the limited cutaneous form of the multisystem connective tissue disorder know
Externí odkaz:
https://doaj.org/article/9e62b3c8f10549beaee3a77b72d12ac2
Autor:
Karim Dardim, Jérôme Fernandes, Arnaud Panes, Julien Beisel, Aurélie Schmidt, Josephine Wolfram, Lora Todorova, Laurence Dubel, Thierry Lobbedez
Publikováno v:
PLoS ONE, Vol 18, Iss 7, p e0287859 (2023)
BackgroundMinimal data are available regarding the prevalence and incidence of anemia among patients with non-dialysis-dependent chronic kidney disease (NDD-CKD) in France.MethodsThis was a retrospective non-interventional study of patients with a re
Externí odkaz:
https://doaj.org/article/63c62c46cda340849d56e44cfd772a87
Autor:
Laurence Dube, Richard Friesen, Karen Townson, Daniel Dube, Jean-François Lévesque, Susana Liu, Michel Gallant, Dwight Macdonald, Donald W. Nicholson, Zheng Huang, Renee Aspiotis, Rebecca Dias, Sebastien Laliberte, Patrick Lacombe, Pierre Hamel, Daniel Guay, Kerry A. Waters, Mario Girard, Joseph A. Mancini, Stephen Day, Robert N. Young, Angela Styhler, Yves Girard
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(22)
The structure-activity relationship of a novel series of 8-biarylnaphthyridinones acting as type 4 phosphodiesterase (PDE4) inhibitors for the treatment of long-term memory loss and mild cognitive impairment is described herein. The manuscript descri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2255fde5f2d2efbe35673f8b5806fa8e
https://pubmed.ncbi.nlm.nih.gov/20933411
https://pubmed.ncbi.nlm.nih.gov/20933411
Autor:
Laurence Dube, David Martin, Daniel Dube, Dan McKay, Michel Gallant, Robert Houle, Austin Chen, Dwight Macdonald, Bruce Mackay, Erich L. Grimm, Suzanna Liu, Sebastien Laliberte, Patrick Lacombe, Sébastien Gagné, David A. Powell, Mireille Gaudreault, Jean-François Lévesque
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(17)
Time-dependent inhibitors of CYPs have the potential to perpetrate drug-drug interactions in the clinical setting. After finding that several leading compounds in a novel series of substituted amino propanamide renin inhibitors inactivated CYP3A4 in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f193309cdedef2ef1eb3b94189c04f54
https://pubmed.ncbi.nlm.nih.gov/20673718
https://pubmed.ncbi.nlm.nih.gov/20673718
Autor:
Laurence Dube, Ian Egle, Jack Peragine, Keith Jarvie, Jalaj Arora, Ashok Tehim, Michel Bordeleau, Lucy Mazzocco
Publikováno v:
Bioorganicmedicinal chemistry letters. 15(23)
A series of N-[(3S)-1-benzylpyrrolidin-3-yl]-(2-thienyl)benzamides 8 has been prepared and found to bind with high affinity to the human D(4) (hD(4)) and 5-HT(2A) receptors. Several compounds displayed selectivity for these receptors versus hD(2) and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec0cb647f1d3b836229fc07160746d3e
https://pubmed.ncbi.nlm.nih.gov/16168646
https://pubmed.ncbi.nlm.nih.gov/16168646