The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity

Autor: Benoît Bragantini, Christophe Charron, Maxime Bourguet, Arnaud Paul, Decebal Tiotiu, Benjamin Rothé, Hélène Marty, Guillaume Terral, Steve Hessmann, Laurence Decourty, Marie-Eve Chagot, Jean-Marc Strub, Séverine Massenet, Edouard Bertrand, Marc Quinternet, Cosmin Saveanu, Sarah Cianférani, Stéphane Labialle, Xavier Manival, Bruno Charpentier

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Biogenesis of small nucleolar RNAs ribonucleoproteins (snoRNPs) requires dedicated assembly machinery. Here, the authors show that a subset of snoRNP assembly factors interacts, genetically or directly, with factors modulating chromatin architecture,

Externí odkaz: https://doaj.org/article/334ab11b5a9d40c685790e1db511ecac

Long Open Reading Frame Transcripts Escape Nonsense-Mediated mRNA Decay in Yeast

Autor: Laurence Decourty, Antonia Doyen, Christophe Malabat, Emmanuel Frachon, Delphine Rispal, Bertrand Séraphin, Frank Feuerbach, Alain Jacquier, Cosmin Saveanu

Publikováno v: Cell Reports, Vol 6, Iss 4, Pp 593-598 (2014)

Nonsense-mediated mRNA decay (NMD) destabilizes eukaryotic transcripts with long 3′ UTRs. To investigate whether other transcript features affect NMD, we generated yeast strains expressing chromosomal-derived mRNAs with 979 different promoter and o

Externí odkaz: https://doaj.org/article/7e77ba57b9334124ad7b0f22e19c7d82

Deadenylation rate is not a major determinant of RNA degradation in yeast

Autor: Léna Audebert, Frank Feuerbach, Laurence Decourty, Abdelkader Namane, Emmanuelle Permal, Gwenaël Badis, Cosmin Saveanu

Gene expression and its regulation depend on mRNA degradation. In eukaryotes, degradation is controlled by deadenylation rates, since a short poly(A) tail is considered to be the signal that activates decapping and triggers mRNA degradation. In contr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aced56b419332ca667440f6e9b0b33c
https://doi.org/10.1101/2023.01.16.524186

The box C/D snoRNP assembly factor Bcd1 interacts with the histone chaperone Rtt106 and controls its transcription dependent activity

Autor: Laurence Decourty, Séverine Massenet, Stéphane Labialle, Marie-Eve Chagot, Guillaume Terral, Benoît Bragantini, Marc Quinternet, Maxime Bourguet, Cosmin Saveanu, Edouard Bertrand, Decebal Tiotiu, Christophe Charron, Sarah Cianférani, Bruno Charpentier, Xavier Manival, Jean-Marc Strub, Arnaud Paul, Steve Hessmann, Hélène Marty, Benjamin Rothé

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2021, 12 (1), pp.1859. ⟨10.1038/s41467-021-22077-4⟩
Nature Communications, 2021, 12 (1), pp.1859. ⟨10.1038/s41467-021-22077-4⟩
'Nature Communications ', vol: 12, pages: 1859-1-1859-17 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)

Biogenesis of eukaryotic box C/D small nucleolar ribonucleoproteins initiates co-transcriptionally and requires the action of the assembly machinery including the Hsp90/R2TP complex, the Rsa1p:Hit1p heterodimer and the Bcd1 protein. We present geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::67633b11639536dd51b6d7c59ecbc1b7
https://hal.univ-lorraine.fr/hal-03181046

Investigation of RNA metabolism through large-scale genetic interaction profiling in yeast

Autor: Cosmin Saveanu, Laurence Decourty, Emmanuel Frachon, Christophe Malabat, Alain Jacquier

Gene deletion and gene expression alteration can lead to growth defects that are amplified or reduced when a second mutation is present in the same cells. We performed 154 genetic interaction mapping (GIM) screens with mutants related with RNA metabo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f083dbc23c88422be3a655c3ce4c17db
https://doi.org/10.1101/2020.10.04.325191