Structural basis of HCV neutralization by human monoclonal antibodies resistant to viral neutralization escape.

Autor: Thomas Krey, Annalisa Meola, Zhen-Yong Keck, Laurence Damier-Piolle, Steven K H Foung, Felix A Rey

Publikováno v: PLoS Pathogens, Vol 9, Iss 5, p e1003364 (2013)

The high mutation rate of hepatitis C virus allows it to rapidly evade the humoral immune response. However, certain epitopes in the envelope glycoproteins cannot vary without compromising virus viability. Antibodies targeting these epitopes are resi

Externí odkaz: https://doaj.org/article/7a34f878544d4b63971ddd2895bc189d

An alpaca nanobody inhibits hepatitis C virus entry and cell-to-cell transmission

Autor: Pierre Lafaye, Laurence Damier-Piolle, Félix A. Rey, Alexander W. Tarr, Jane A. McKeating, Richard J. C. Brown, Luke W. Meredith, Jean-Luc Jestin, Annalisa Meola, Richard A. Urbanowicz, Thomas Krey, Jonathan K. Ball

Publikováno v: Hepatology. 58:932-939

Severe liver disease caused by chronic hepatitis C virus is the major indication for liver transplantation. Despite recent advances in antiviral therapy, drug toxicity and unwanted side effects render effective treatment in liver-transplanted patient

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5851fde0afa4bd6403a3bb50328fa3e2
https://doi.org/10.1002/hep.26430

The disulfide bonds in glycoprotein E2 of hepatitis C virus reveal the tertiary organization of the molecule

Autor: Félix A. Rey, Aure Saulnier, Annette Martin, Patrick England, Carlos M. Kikuti, Bruno Baron, Bruno Robert, I. Petitpas, Mats A. A. Persson, Laurence Damier-Piolle, Rajiv G. Tawar, Daniel X. Johansson, Thomas Krey, Jacques d'Alayer

Publikováno v: PLoS Pathogens, Vol 6, Iss 2, p e1000762 (2010)
PLoS Pathogens
PLoS Pathogens, Public Library of Science, 2010, 6 (2), pp.e1000762. ⟨10.1371/journal.ppat.1000762⟩
PLoS Pathogens, 2010, 6 (2), pp.e1000762. ⟨10.1371/journal.ppat.1000762⟩

Hepatitis C virus (HCV), a major cause of chronic liver disease in humans, is the focus of intense research efforts worldwide. Yet structural data on the viral envelope glycoproteins E1 and E2 are scarce, in spite of their essential role in the viral

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f65baf646a5f2d203413ee015c250fd2
http://europepmc.org/articles/PMC2824758?pdf=render

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

Autor: Annalisa Meola, Steven K. H. Foung, Thomas Krey, Laurence Damier-Piolle, Félix A. Rey, Zhen-Yong Keck

Publikováno v: PLoS Pathogens, Vol 9, Iss 5, p e1003364 (2013)
PLoS Pathogens
PLoS Pathogens, 2013, 9 (5), pp.e1003364. ⟨10.1371/journal.ppat.1003364⟩

The high mutation rate of hepatitis C virus allows it to rapidly evade the humoral immune response. However, certain epitopes in the envelope glycoproteins cannot vary without compromising virus viability. Antibodies targeting these epitopes are resi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7812af2d83ad672e58042386a812669
https://doi.org/10.1371/journal.ppat.1003364

Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

Autor: Krey, Thomas^1,2 tkrey@pasteur.fr, Meola, Annalisa^1,2, Keck, Zhen-yong³, Damier-Piolle, Laurence^1,2, Foung, Steven K. H.³, Rey, Felix A.^1,2

Publikováno v: PLoS Pathogens. May2013, Vol. 9 Issue 5, p1-10. 10p. 3 Diagrams, 1 Chart, 1 Graph.