Deep-learning-derived input function in dynamic [18F]FDG PET imaging of mice

Autor: Samuel Kuttner, Luigi T. Luppino, Laurence Convert, Otman Sarrhini, Roger Lecomte, Michael C. Kampffmeyer, Rune Sundset, Robert Jenssen

Publikováno v: Frontiers in Nuclear Medicine, Vol 4 (2024)

Dynamic positron emission tomography and kinetic modeling play a critical role in tracer development research using small animals. Kinetic modeling from dynamic PET imaging requires accurate knowledge of an input function, ideally determined through

Externí odkaz: https://doaj.org/article/a2f205c353d544dbaaca7c31c1b0ff70

Real-Time Microfluidic Blood-Counting System for PET and SPECT Preclinical Pharmacokinetic Studies

Autor: Jean-Francois Pratte, Réjean Lebel, Vincent Aimez, Roger Lecomte, Suzanne Gascon, Rejean Fontaine, Paul G. Charette, Laurence Convert

Publikováno v: Journal of Nuclear Medicine
Journal of Nuclear Medicine, Society of Nuclear Medicine, 2016, 57 (9), pp.1460-1466. ⟨10.2967/jnumed.115.162768⟩

Small-animal nuclear imaging modalities have become essential tools in the development process of new drugs, diagnostic procedures, and therapies. Quantification of metabolic or physiologic parameters is based on pharmacokinetic modeling of radiotrac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9abea8a2eff948278a37d3bebdcebcbb
https://doi.org/10.2967/jnumed.115.162768

High efficiency microfluidic beta detector for pharmacokinetic studies in small animals

Autor: Alan Renaudin, Abdelatif Jaouad, Frédérique Girard-Baril, Etienne Grondin, Vincent Aimez, Laurence Convert, Paul G. Charette, Roger Lecomte

Publikováno v: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment. 652:735-738

New radiotracers are continuously being developed to improve diagnostic efficiency using Single Photon Emission Computed Tomography (SPECT) or Positron Emission Tomography (PET). The characterization of their pharmacokinetics requires blood radioacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::86be69915a4e322ba38c1471dbf7df5c
https://doi.org/10.1016/j.nima.2010.09.111

Microfluidic beta and conversion electron radiation detector for preclinical pharmacokinetic studies with PET and SPECT radiotracers

Autor: Rejean Fontaine, Jean-Francois Pratte, Vincent Aimez, F. Girard-Baril, Paul G. Charette, Roger Lecomte, Laurence Convert, V. Boisselle

Publikováno v: IEEE Nuclear Science Symposuim & Medical Imaging Conference.

The characterization of new radiotracer pharmacokinetics in small animals is very challenging because of the small volume of blood available. For this purpose, a microfluidic blood counter prototype made of a microchannel on silicon containing PIN ph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::11f91abc5087e41c8f2e0ed5208e73f5
https://doi.org/10.1109/nssmic.2010.5874155

A new tool for molecular imaging: the microvolumetric beta blood counter

Autor: Roger Lecomte, Laurence Convert, Mélanie Archambault, Jules Cadorette, Guillaume Morin-Brassard, M'hamed Bentourkia

Publikováno v: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 48(7)

Radiotracer kinetic modeling in small animals with PET allows absolute quantification of physiologic and biochemical processes in vivo. It requires blood and tissue tracer concentrations as a function of time. Manual sampling, the reference method fo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::739668223b8681fc529507764c5382d1
https://pubmed.ncbi.nlm.nih.gov/17574990