Zobrazeno 1 - 10
of 30
pro vyhledávání: '"Laurence Brugiere"'
Autor:
Amélie Roehrig, Theo Z. Hirsch, Aurore Pire, Guillaume Morcrette, Barkha Gupta, Charles Marcaillou, Sandrine Imbeaud, Christophe Chardot, Emmanuel Gonzales, Emmanuel Jacquemin, Masahiro Sekiguchi, Junko Takita, Genta Nagae, Eiso Hiyama, Florent Guérin, Monique Fabre, Isabelle Aerts, Sophie Taque, Véronique Laithier, Sophie Branchereau, Catherine Guettier, Laurence Brugières, Brice Fresneau, Jessica Zucman-Rossi, Eric Letouzé
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract Hepatoblastomas (HB) display heterogeneous cellular phenotypes that influence the clinical outcome, but the underlying mechanisms are poorly understood. Here, we use a single-cell multiomic strategy to unravel the molecular determinants of t
Externí odkaz:
https://doaj.org/article/14c4d115a5e440889f8a8405c0ba7b92
Autor:
Jill Pilet, Theo Z. Hirsch, Barkha Gupta, Amélie Roehrig, Guillaume Morcrette, Aurore Pire, Eric Letouzé, Brice Fresneau, Sophie Taque, Laurence Brugières, Sophie Branchereau, Christophe Chardot, Isabelle Aerts, Sabine Sarnacki, Monique Fabre, Catherine Guettier, Sandra Rebouissou, Jessica Zucman-Rossi
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Pediatric liver tumors are very rare tumors with the most common diagnosis being hepatoblastoma. While hepatoblastomas are predominantly sporadic, around 15% of cases develop as part of predisposition syndromes such as Beckwith-Wiedemann (11
Externí odkaz:
https://doaj.org/article/b855b46d29ee498d9b652b37172ee706
Autor:
Charlotte Rigaud, Samuel Abbou, Stephane Ducassou, Mathieu Simonin, Lou Le Mouel, Victor Pereira, Stephanie Gourdon, Anne Lambilliotte, Birgit Geoerger, Veronique Minard-Colin, Laurence Brugieres
Publikováno v:
Haematologica, Vol 107, Iss 9 (2022)
Externí odkaz:
https://doaj.org/article/1abe8705448e4f5d86c7a4e2495fabc0
Autor:
Marie-Dominique Tabone, Laurence Brugières, Sophie Piperno-Neumann, Marie-Ange Selva, Perrine Marec-Bérard, Hélène Pacquement, Cyril Lervat, Nadège Corradini, Jean-Claude Gentet, Rémy Couderc, Aurélie Chevance, Céline Mahier-Ait Oukhatar, Natacha Entz-Werle, Jean-Yves Blay, Marie-Cecile Le Deley
Publikováno v:
BMC Cancer, Vol 17, Iss 1, Pp 1-10 (2017)
Abstract Background Angiogenesis is essential for the progression and metastatic spread of solid tumours. Expression of vascular endothelial growth factor (VEGF) has been linked to poor survival among osteosarcoma patients but the clinical relevance
Externí odkaz:
https://doaj.org/article/1045f74df09a40b1a55af072986c74a6
Autor:
Hanna IJspeert, Pauline A. van Schouwenburg, Ingrid Pico-Knijnenburg, Jan Loeffen, Laurence Brugieres, Gertjan J. Driessen, Claudia Blattmann, Manon Suerink, Danuta Januszkiewicz-Lewandowska, Amedeo A. Azizi, Marcus G. Seidel, Heinz Jacobs, Mirjam van der Burg
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The generation of high-affinity antibodies depends on somatic hypermutation (SHM). SHM is initiated by the activation-induced cytidine deaminase (AID), which generates uracil (U) lesions in the B-cell receptor (BCR) encoding genes. Error-prone proces
Externí odkaz:
https://doaj.org/article/02fdf5b9344e419387263bfb88fdd747
Autor:
Marine Huby, Laurence Brugières, Eric Mascard, Nathalie Gaspar, Stéphanie Pannier, Jean-Charles Aurégan
Publikováno v:
Case Reports in Orthopedics, Vol 2019 (2019)
Li-Fraumeni syndrome is a rare inherited disease characterized by the early onset of multiple primary malignant tumors. Sarcomas account for more than 30% of all malignant tumors occurring at pediatric age. Furthermore, it was shown that the rates of
Externí odkaz:
https://doaj.org/article/2f3eb36719734812a4109c731ea72d96
Autor:
Victoria K. Tesch, Hanna IJspeert, Andrea Raicht, Daniel Rueda, Nerea Dominguez-Pinilla, Luis M. Allende, Chrystelle Colas, Thorsten Rosenbaum, Denisa Ilencikova, Hagit N. Baris, Michaela H. M. Nathrath, Manon Suerink, Danuta Januszkiewicz-Lewandowska, Iman Ragab, Amedeo A. Azizi, Soeren S. Wenzel, Johannes Zschocke, Wolfgang Schwinger, Matthias Kloor, Claudia Blattmann, Laurence Brugieres, Mirjam van der Burg, Katharina Wimmer, Markus G. Seidel
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
Immunoglobulin class-switch recombination (CSR) and somatic hypermutations (SHMs) are prerequisites for antibody and immunoglobulin receptor maturation and adaptive immune diversity. The mismatch repair (MMR) machinery, consisting of homologs of MutS
Externí odkaz:
https://doaj.org/article/34b5e5ca683a46b5b6319eb07943d6d2
Autor:
Anne Gomez-Brouchet, Claire Illac, Julia Gilhodes, Corinne Bouvier, Sébastien Aubert, Jean-Marc Guinebretiere, Béatrice Marie, Frédérique Larousserie, Natacha Entz-Werlé, Gonzague de Pinieux, Thomas Filleron, Véronique Minard, Vincent Minville, Eric Mascard, François Gouin, Marta Jimenez, Marie-Cécile Ledeley, Sophie Piperno-Neumann, Laurence Brugieres, Françoise Rédini
Publikováno v:
OncoImmunology, Vol 6, Iss 9 (2017)
The French phase 3 trial (OS 2006) testing zoledronic acid, an osteoclast inhibitor, with chemotherapy and surgery did not improve the outcome of patients with osteosarcoma (OS). To understand this unexpected result, the presence of infiltrating immu
Externí odkaz:
https://doaj.org/article/22862af3f75941cab3151166cb91d536
Autor:
Andishe Attarbaschi, Elisa Carraro, Oussama Abla, Shlomit Barzilai-Birenboim, Simon Bomken, Laurence Brugieres, Eva Bubanska, Birgit Burkhardt, Alan K.S. Chiang, Monika Csoka, Alina Fedorova, Janez Jazbec, Edita Kabickova, Zdenka Krenova, Jelena Lazic, Jan Loeffen, Georg Mann, Felix Niggli, Natalia Miakova, Tomoo Osumi, Leila Ronceray, Anne Uyttebroeck, Denise Williams, Wilhelm Woessmann, Grazyna Wrobel, Marta Pillon
Publikováno v:
Haematologica, Vol 101, Iss 12 (2016)
Children and adolescents with pre-existing conditions such as DNA repair defects or other primary immunodeficiencies have an increased risk of non-Hodgkin lymphoma. However, large-scale data on patients with non-Hodgkin lymphoma and their entire spec
Externí odkaz:
https://doaj.org/article/1dc6d42f02884cda90cf605fdcfa1d7c
Autor:
Natacha Entz-Werle, Thomas Lavaux, Nadia Metzger, Corinne Stoetzel, Christelle Lasthaus, Perrine Marec, Chantal Kalita, Laurence Brugieres, Helene Pacquement, Claudine Schmitt, Marie-Dominique Tabone, Jean-Claude Gentet, Patrick Lutz, Annie Babin, Pierre Oudet, Marie Pierre Gaub, Fabienne Perrin-Schmitt
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 8, Pp 678-688 (2007)
Dysregulated cell growth or differentiation due to misexpression of developmental critical factors seems to be a decisive event in oncogenesis. As osteosarcomas are histologically defined by malignant osteoblasts producing an osteoid component, we pr
Externí odkaz:
https://doaj.org/article/cfc9824b4f324ad5822d130e6c542c0a