Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Laurence Biggers"'
Publikováno v:
PLoS ONE, Vol 19, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/cd322d63f3ad448ca81be682c90732b2
Autor:
Ronak Lakhia, Harini Ramalingam, Chun-Mien Chang, Patricia Cobo-Stark, Laurence Biggers, Andrea Flaten, Jesus Alvarez, Tania Valencia, Darren P. Wallace, Edmund C. Lee, Vishal Patel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
ADPKD, a common aetiology of kidney failure, is caused by heterozygous PKD1 or PKD2 mutations. Here the authors show that preventing 3′-UTR cis-inhibition of mRNAs produced by the non-inactivated PKD1/2 alleles ameliorates preclinical ADPKD.
Externí odkaz:
https://doaj.org/article/5c3d27a136564233923d3e2f24e558f2
Publikováno v:
Protein Sci
An engineered variant of T4 lysozyme serves as a model for studying induced remote conformational changes in a full protein context. The design involves a duplicated surface helix, flanked by two loops, that switches between two different conformatio
Autor:
Laurence Biggers, Venakt Malladi, Patricia Cobo-Stark, Ronak Lakhia, Sachin Hajarnis, Abheepsa Mishra, Vishal Patel
Widespread aberrant gene expression is pathological hallmark of polycystic kidney disease (PKD). Numerous pathogenic signaling cascades, including c-Myc, Fos, and Jun are transactivated. However, the underlying epigenetic regulators are poorly define
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eccc416f7031370e17f6387242e8c124
https://doi.org/10.1101/2021.11.19.469306
https://doi.org/10.1101/2021.11.19.469306
Autor:
Laurence Biggers, Thomas L. Carroll, Peter Igarashi, Ronak Lakhia, Harini Ramalingam, Vishal Patel, Silvia Ferrè, Darren P. Wallace, Karam Aboudehen, Matanel Yheskel, Abheepsa Mishra, Andrea Flaten, Christopher P. Chaney
Publikováno v:
JCI Insight
Renal cysts are the defining feature of autosomal dominant polycystic kidney disease (ADPKD); however, the substantial interstitial inflammation is an often-overlooked aspect of this disorder. Recent studies suggest that immune cells in the cyst micr
Autor:
Ackad, Edward Michael1 (AUTHOR) eackad@siue.edu, Biggers, Laurence2 (AUTHOR), Meister, Mary3 (AUTHOR), Kontoyianni, Maria4 (AUTHOR)
Publikováno v:
PLoS ONE. 3/18/2024, Vol. 19 Issue 3, p1-24. 24p.
Autor:
Lakhia, Ronak, Ramalingam, Harini, Chang, Chun-Mien, Cobo-Stark, Patricia, Biggers, Laurence, Flaten, Andrea, Alvarez, Jesus, Valencia, Tania, Wallace, Darren P., Lee, Edmund C., Patel, Vishal
Publikováno v:
Nature Communications; 8/15/2022, Vol. 13 Issue 1, p1-14, 14p
Publikováno v:
Protein Science: A Publication of the Protein Society; Feb2020, Vol. 29 Issue 2, p542-554, 13p
Publikováno v:
Annals of Human Biology; 1986, Vol. 13 Issue 6, p537-545, 9p