Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Laurence Barrier"'
Publikováno v:
International Journal of Alzheimer's Disease, Vol 2011 (2011)
There is evidence linking sphingolipid abnormalities, APP processing, and neuronal death in Alzheimer's disease (AD). We previously reported a strong elevation of ceramide levels in the brain of the APPSL/PS1Ki mouse model of AD, preceding the neuron
Externí odkaz:
https://doaj.org/article/ee735e4e682345e7962bb25810dcdb8f
Autor:
Marjorie Laurence Barrier, Iwona Teresa Myszor, Priyanka Sahariah, Snaevar Sigurdsson, Miguel Carmena-Bargueño, Horacio Pérez-Sánchez, Gudmundur Hrafn Gudmundsson
Publikováno v:
Molecular Immunology. 155:153-164
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::10ecaa867b3faa747047650d583d77f3
https://doi.org/10.1016/j.molimm.2023.02.003
https://doi.org/10.1016/j.molimm.2023.02.003
Ganglioside and related-sphingolipid profiles are altered in a cellular model of Alzheimer's disease
Publikováno v:
Biochimie. 137:158-164
Sphingolipid-related issues are increasingly discussed to contribute to the neuropathological process of Alzheimer's disease (AD). In this study, gangliosides and related-sphingolipids (ceramides, neutral glycosphingolipids and sphingomyelins) were a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57de56a47dada1e7b50c8e425d4020bc
https://doi.org/10.1016/j.biochi.2017.03.019
https://doi.org/10.1016/j.biochi.2017.03.019
Publikováno v:
Molecular and Cellular Neuroscience. 75:63-70
Evidence has suggested that ganglioside abnormalities may be linked to the proteolytic processing of amyloid precursor protein (APP) in Alzheimer's disease (AD) and that pharmacological inhibition of ganglioside synthesis may reduce amyloid β-peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2eb92bf4e05e4c5720c46c4cfc18152
https://doi.org/10.1016/j.mcn.2016.06.009
https://doi.org/10.1016/j.mcn.2016.06.009
Publikováno v:
Life Sciences. 158:14-21
Aims GSK3β activation in Aβ conditions leading to tau phosphorylation at pathological sites is a well-known phenomenon. However, the serine/tyrosine phosphorylation processes implied in Aβ-induced GSK3β activation and responsible for tau phosphor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36d8e5937b461b4e59328bf2f75185d1
https://doi.org/10.1016/j.lfs.2016.06.020
https://doi.org/10.1016/j.lfs.2016.06.020
Publikováno v:
Experimental Neurology. 271:308-318
Accumulating evidence implicates ganglioside and/or related-sphingolipid disturbance in the pathogenesis of Alzheimer's disease (AD). However, it is not known whether these lipidic alterations are connected with other important features of AD, such a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42e75da7badca2d78bfa0c4307360aa4
https://doi.org/10.1016/j.expneurol.2015.06.021
https://doi.org/10.1016/j.expneurol.2015.06.021
Autor:
Guylène Page, Sabrina Ingrand, Laurence Barrier, Milena Damjanac, Agnès Rioux Bilan, Jacques Hugon
Publikováno v:
Neurobiology of Aging. 28:1863-1872
In this study, brain gangliosides of different transgenic mouse models of Alzheimer's disease (AD) were analyzed and compared with age-matched wild-type mice. Gangliosides were analyzed in cerebral cortex, a region with extensive A beta plaques, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0b824cb0d771d128c9992d4ec6ca65
https://doi.org/10.1016/j.neurobiolaging.2006.08.002
https://doi.org/10.1016/j.neurobiolaging.2006.08.002
Autor:
Sabrina Ingrand, Claire Lafay-Chebassier, Jacques Hugon, Laurence Barrier, Bernard Fauconneau, Guylène Page
Publikováno v:
FEBS Letters. 581:4473-4478
Inhibition of double-stranded RNA-dependent protein kinase (PKR) represents an interesting strategy for neuroprotection. However, inhibiting this kinase which triggers the apoptotic process could favour in counterpart cell proliferation and tumorigen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8915dc224e663d84d9b63e6e4e5d7c73
https://doi.org/10.1016/j.febslet.2007.08.022
https://doi.org/10.1016/j.febslet.2007.08.022
Autor:
Sabrina Ingrand, Olivier Guillard, Stéphanie Pain, Alain Piriou, Guylène Page, Laurence Barrier, Nadine Vantelon, Bernard Fauconneau, Agnès Rioux-Bilan
Publikováno v:
European Journal of Neuroscience. 26:689-700
The goals of this work were first to assess whether the lactic acidosis observed in vivo in ischemia may by itself explain the inhibition of protein synthesis described in the literature and second to study the factors controlling the initiation of p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::076adb507a816c11ad8253c6ed521d3d
https://doi.org/10.1111/j.1460-9568.2007.05698.x
https://doi.org/10.1111/j.1460-9568.2007.05698.x
Autor:
Jacques Hugon, Agnès Rioux Bilan, Milena Damjanac, Guylène Page, Cantereau Anne, Raymond Pontcharraud, Laurence Barrier
Publikováno v:
Brain Research
Brain Research, Elsevier, 2006, 1128, pp.40-49. ⟨10.1016/j.brainres.2006.05.050⟩
Brain Research, Elsevier, 2006, 1128, pp.40-49. ⟨10.1016/j.brainres.2006.05.050⟩
International audience; Fluoro-Jade ® B is known as a high affinity fluorescent marker for the localization of neuronal degeneration during acute neuronal distress. However, one study suggested that fluoro-Jade ® B stains reactive astroglia in the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba3af64778a434f6be9765acc815c4a3
https://doi.org/10.1016/j.brainres.2006.05.050
https://doi.org/10.1016/j.brainres.2006.05.050