Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Laurence Ayvazian"'
Autor:
Catherine Chapus, Laurence Ayvazian, Simone Granon, Brigitte Kerfelec, Isabelle Crenon, Edith Foglizzo, Christophe Dubois
Publikováno v:
Journal of Biological Chemistry. 276:14014-14018
In vertebrates, dietary fat digestion mainly results from the combined effect of pancreatic lipase, colipase, and bile. It has been proposed that in vivo lipase adsorption on oil-water emulsion is mediated by a preformed lipase-colipase-mixed micelle
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1d2dbc73e346b7dc02843e17755debd9
https://doi.org/10.1074/jbc.m010328200
https://doi.org/10.1074/jbc.m010328200
Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering
Autor:
Laurence Ayvazian, Catherine Chapus, Peter Timmins, Juan C. Fontecilla-Camps, Brigitte Kerfelec, Juan A. Hermoso, Isabelle Crenon, David Pignol
Publikováno v:
The Journal of biological chemistry. 275(6)
In the duodenum, pancreatic lipase (PL) develops its activity on triglycerides by binding to the bile-emulsified oil droplets in the presence of its protein cofactor pancreatic colipase (PC). The neutron crystal structure of a PC-PL-micelle complex (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56f918e0f576eacd2511e2e0ac87c1eb
https://pubmed.ncbi.nlm.nih.gov/10660587
https://pubmed.ncbi.nlm.nih.gov/10660587
Autor:
Juan A. Hermoso, Laurence Ayvazian, Brigitte Kerfelec, Catherine Chapus, Isabelle Crenon, David Pignol
Publikováno v:
The Journal of biological chemistry. 273(50)
Among the polar interactions occurring in pancreatic lipase/colipase binding, only one ion pair involving lysine 400 on lipase and glutamic acid 45 on colipase has been described. These residues are strictly conserved among species, suggesting that t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30e20b7192d6ca7c1cf7477e33496f1
https://pubmed.ncbi.nlm.nih.gov/9837944
https://pubmed.ncbi.nlm.nih.gov/9837944
Publikováno v:
Protein engineering. 9(8)
The organization of the pancreatic lipase in two well defined domains has been correlated to a specific function for each domain, catalytic activity for the N-terminal domain and colipase binding for the C-terminal domain. In order to see if such an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233574fd25df5b1d8620aa1177e35ce7
https://pubmed.ncbi.nlm.nih.gov/8875648
https://pubmed.ncbi.nlm.nih.gov/8875648