Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Laurence Antonio"'
Autor:
Laurence Antonio, Juliet A. Gerrard, F. Grant Pearce, Geoffrey B. Jameson, Andrew E. Whitten, Renwick C. J. Dobson, Michael D. W. Griffin, Matthew A. Perugini, Jill Trewhella, Joel P. Mackay, Chu K. Liew
Publikováno v:
Journal of Molecular Biology. 380:691-703
Dihydrodipicolinate synthase (DHDPS) is an essential enzyme in (S)-lysine biosynthesis and an important antibiotic target. All X-ray crystal structures solved to date reveal a homotetrameric enzyme. In order to explore the role of this quaternary str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f450e661e922d2f8848713252be12a23
https://doi.org/10.1016/j.jmb.2008.05.038
https://doi.org/10.1016/j.jmb.2008.05.038
Autor:
Laurence Antonio, Anna Radominska-Pandya, Joanna M. Little, Jing Xu, Brian Burchell, Jacques Magdalou
Publikováno v:
Archives of Biochemistry and Biophysics. 411:251-261
The substrate specificity of human gastric and intestinal UDP-glucuronosyltransferases (UGTs) toward catechols was investigated and compared to that of liver UGTs. Small catechols were efficiently glucuronidated by stomach (0.8-10.2 nmol/mgprotein x
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17660385267cc570d4793110ab6a3305
https://doi.org/10.1016/s0003-9861(02)00748-8
https://doi.org/10.1016/s0003-9861(02)00748-8
Autor:
Eivor Elovaara, Jacques Magdalou, Sylvie Fournel-Gigleux, Laurence Antonio, Marie-Helene Piet, Mohamed Ouzzine, Joël-Paul Grillasca, Brian T. Ethell, Jyrki Taskinen, Brian Burchell
Publikováno v:
Drug Metabolism and Disposition. 30:199-207
Catechols are a class of substances from natural or synthetic origin that contain a 1,2-dihydroxybenzene group. We have characterized the glucuronidation by rat liver microsomes and by the rat liver recombinant UDP-glucuronosyltransferase isoforms UG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619b1f1c614c8cb469fe83094cf7d1bb
https://doi.org/10.1124/dmd.30.2.199
https://doi.org/10.1124/dmd.30.2.199
Autor:
Laurence Antonio, Jacques Magdalou, Mohamed Ouzzine, Brian Burchell, Sylvie Fournel-Gigleux, Patrick Netter
Publikováno v:
Molecular Pharmacology. 58:1609-1615
The human UDP-glucuronosyltransferase isoform UGT1A6 catalyzes the nucleophilic attack of phenolic xenobiotics on glucuronic acid, leading to the formation of water-soluble glucuronides. Based on the irreversible inhibition of the enzyme activity by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3232c39b015cb3481e576f901541fb63
https://doi.org/10.1124/mol.58.6.1609
https://doi.org/10.1124/mol.58.6.1609
Autor:
Leena Luukkanen, Risto Kostiainen, Eivor Elovaara, Helena Keski-Hynnilä, Jyrki Taskinen, Laurence Antonio, Mika Kurkela, Jacques Magdalou
Publikováno v:
Analytical chemistry. 74(14)
The applicability of different ionization techniques, electrospray ionization (ESI), atmospheric pressure chemical ionization (APCI), and a novel atmospheric pressure photoionization (APPI), were tested for the identification of the phase II metaboli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c142a08d13bcb3ebadd484d3a7e5ea2
https://pubmed.ncbi.nlm.nih.gov/12139053
https://pubmed.ncbi.nlm.nih.gov/12139053
Autor:
Laurence, Antonio, Jol-Paul, Grillasca, Jyrki, Taskinen, Eivor, Elovaara, Brian, Burchell, Marie-Helene, Piet, Brian, Ethell, Mohamed, Ouzzine, Sylvie, Fournel-Gigleux, Jacques, Magdalou
Publikováno v:
Drug Metabolism and Disposition; February 2002, Vol. 30 Issue: 2 p199-207, 9p