Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Laurence Anne Mevellec"'
Autor:
Jorge Vialard, Kelly Federowicz, Geoff Struble, Weixue Wang, Samantha J Allen, Daniel Jason Krosky, Annie Liu, Robyn L. Miller, Berthold Wroblowski, Kay Ahn, Laurence Anne Mevellec
Publikováno v:
Biochemistry. 60(41)
Achieving selectivity across the human kinome is a major hurdle in kinase inhibitor drug discovery. Assays using active, phosphorylated protein kinases bias hits toward poorly selective inhibitors that bind within the highly conserved adenosine triph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a434c7c0f939d41bacdd35042e3e1f1e
https://pubmed.ncbi.nlm.nih.gov/34608799
https://pubmed.ncbi.nlm.nih.gov/34608799
Autor:
Peter King, Suso Platero, Matthew V. Lorenzi, Kelly Van De Ven, Caroline Paulussen, Liang Xie, Jennifer Yang, Jorge Vialard, Christopher Moy, Eleonora Jovcheva, Timothy Perera, David R. Newell, Jayaprakash Karkera, Sylvie Laquerre, Martin Page, Ron Gilissen, David C. Rees, Neil T. Thompson, George Ward, Desiree De Lange, Laurence Anne Mevellec, Patrick Angibaud, Matthew S Squires, Tinne Verhulst, Na Cheng, Eddy Jean Edgard Freyne, Christopher William Murray, Gordon Saxty
Publikováno v:
Molecular Cancer Therapeutics. 16:1010-1020
Fibroblast growth factor (FGF) signaling plays critical roles in key biological processes ranging from embryogenesis to wound healing and has strong links to several hallmarks of cancer. Genetic alterations in FGF receptor (FGFR) family members are a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b4415ac185c23833df1086dc6f666f7
https://doi.org/10.1158/1535-7163.mct-16-0589
https://doi.org/10.1158/1535-7163.mct-16-0589
Autor:
Timothy Perera, Tinne Verhulst, Boudewijn Janssens, Glen Clack, Marion Libouban, Eleonora Jovcehva, Souichi Ogata, Berthold Wroblowski, Desiree De Lange, Laurence Anne Mevellec, Tianbao Lu
Publikováno v:
Cancer Research. 78:4791-4791
Activation of the MET/HGF pathway has been linked to tumor initiation, metastasis, angiogenesis and resistance to therapeutic agents. Here we present pharmacological characterization of OMO-1 (formerly JNJ-38877618), a potent, highly selective, orall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::075f06cdf2ceac4069f4bb5df1069441
https://doi.org/10.1158/1538-7445.am2018-4791
https://doi.org/10.1158/1538-7445.am2018-4791
Autor:
Laurence Anne Mevellec, Ian Stansfield, Lars Neumann, Matthias Versele, G Karthikeyan, Nicolas Winssinger, Ricardo Attar, Martin Augustin, Lieven Meerpoel, M Röthlingshöfer, Sofia Barluenga, Ron Gilissen, Berthold Wroblowski, Jan Cools, Kris Jacobs, Burkhard Haefner
Publikováno v:
Cancer Research. 76:4800-4800
Inhibition of Flt3 kinase activity is a promising strategy for the treatment of Flt3 mutant acute myeloid leukemia (AML). However, clinical studies with Flt3 kinase inhibitors have shown that mutations of the gate keeper or an activation loop residue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f07d368b46c2badd110df2eb533b648f
https://doi.org/10.1158/1538-7445.am2016-4800
https://doi.org/10.1158/1538-7445.am2016-4800
Autor:
Berthold Wroblowski, Norbert Esser, Matthew S Squires, Ron Gilissen, Neil Thompson, Lynsey Fazal, David R. Newell, Patrick Angibaud, George Ward, Laurence Anne Mevellec, Gordon Saxty, Tinne Verhulst, Timothy Perera, Eddy Jean Edgard Freyne, Peter King, Eleanora Jovcheva, Christopher William Murray, Jorge Vialard, Suso Platero, Olivier Querolle
Publikováno v:
Cancer Research. 74:1738-1738
The fibroblast growth factor (FGF) signaling axis is increasingly implicated in tumorigenesis and chemoresistance. Alterations in FGFR family members including focal amplification of FGF receptor 1 (FGFR1), mutations in FGFR 2, 3 and 4, translocation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9160fdb857aedd1d6274678e5d9962e3
https://doi.org/10.1158/1538-7445.am2014-1738
https://doi.org/10.1158/1538-7445.am2014-1738
Autor:
Said Akzinnay, Sophie Descamps, Christophe Adelinet, Jeroen Van De Ven, Thierry François Alain Jean Jousseaume, Lieven Meerpoel, Etienne Daras, Javier Astray Gandara, Nele Van Slycken, Inge Boeckx, Marine Bourgeois, Laurence Anne Mevellec, Berthold Wroblowski, Guillaume Jean Maurice Mercey, Jorge Vialard, Mariette Bekkers, Elisabeth Thérèse Jeanne Pasquier, Aurélie Luguern, Jeanty Matthieu Ludovic, Ron Gilissen, Tinne Verhulst
Publikováno v:
Cancer Research. 74:4745-4745
Chromosomal rearrangements resulting in oncogenic fusion proteins containing the ROS1 receptor tyrosine kinase have been described in subsets of a variety of human malignancies including non-small-cell lung cancer (NSCLC), cholangiocarcinoma, and gli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::85e989182ba8b5372717f9c85e176ede
https://doi.org/10.1158/1538-7445.am2014-4745
https://doi.org/10.1158/1538-7445.am2014-4745
Autor:
David C. Rees, Timothy Perera, E Sement, Martin Page, Yannick Ligny, Christopher William Murray, P Benderitter, Rhalid Akkari, Alexandra Papanikos, Andrew Madin, Laurence Anne Mevellec, Janine Arts, Berthold Wroblowski, Y Simmonet, Steve Mcclue, M. Squires, Neil T. Thompson, Ronaldus Arnodus Hendrika Joseph Gilissen, V Berdini, Gordon Saxty, Sharna J. Rich, Pascal Bonnet, Anne Cleasby, H Newell, S. Saalau-Bethell, V. Tronel, Freyne Eddy Jean Edgard, Werner Constant Johan Embrechts, Peter King, Olivier Querolle, Patrick Angibaud, Marc Willems, Jean Fernand Armand Lacrampe, George Ward
Publikováno v:
Cancer Research. 71:1361-1361
Recent data in a number of tumour types has implicated Fibroblast Growth Factor (FGF) and Fibroblast Growth Factor receptor (FGFR) signalling as being key to the molecular pathology of cancer. A fragment screening campaign was conducted against the t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f7c5a52d1de2257d30a9811b29f98374
https://doi.org/10.1158/1538-7445.am2011-1361
https://doi.org/10.1158/1538-7445.am2011-1361