Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Laurence A Lasky"'
Autor:
Raffi Tonikian, Yingnan Zhang, Stephen L Sazinsky, Bridget Currell, Jung-Hua Yeh, Boris Reva, Heike A Held, Brent A Appleton, Marie Evangelista, Yan Wu, Xiaofeng Xin, Andrew C Chan, Somasekar Seshagiri, Laurence A Lasky, Chris Sander, Charles Boone, Gary D Bader, Sachdev S Sidhu
Publikováno v:
PLoS Biology, Vol 6, Iss 9, p e239 (2008)
PDZ domains are protein-protein interaction modules that recognize specific C-terminal sequences to assemble protein complexes in multicellular organisms. By scanning billions of random peptides, we accurately map binding specificity for approximatel
Externí odkaz:
https://doaj.org/article/4ed87eb30eb5451a85620aede5da754a
Publikováno v:
Stem Cells and Development. 14:105-110
Previous studies have demonstrated that mice null (-/-) for either CD34 or c-mpl are viable and have greatly decreased numbers of multipotential (CFU-Mix), erythroid (BFU-E), and granulocytemacrophage (CFU-GM) progenitor cells in the bone marrow (BM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d68600c24e1d281fd67374b7f0c4dee8
https://doi.org/10.1089/scd.2005.14.105
https://doi.org/10.1089/scd.2005.14.105
Autor:
Kerry Zobel, Wai Lee Wong, Sachdev S. Sidhu, Jian Ping Yin, Michael F. T. Koehler, Laurence A. Lasky, M. Theresa Pisabarro, Sherry Yeh, Nicholas J. Skelton
Publikováno v:
Journal of Biological Chemistry. 278:7645-7654
The LAP (leucine-rich repeatand PDZ-containing) family of proteins play a role in maintaining epithelial and neuronal cell size, and mutation of these proteins can have oncogenic consequences. The LAP protein Erbin has been implicated previously in a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::143346cbd8141dae6a282d915194d24f
https://doi.org/10.1074/jbc.m209751200
https://doi.org/10.1074/jbc.m209751200
Autor:
Laurence A. Lasky, Miranda Thomas, Charles L. Sawyers, Karin Hepner, Richard P. Laura, Lawrence Banks, Ernesto Guccione
Publikováno v:
Oncogene. 21:5088-5096
The E6 proteins from the high-risk human papillomavirus (HPV) types have previously been shown to target a number of PDZ domain-containing proteins for proteasome-mediated degradation. These include the hDlg tumour suppressor and the MAGI-1 protein.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1a91319877b185d1f50a0e2e052d14
https://doi.org/10.1038/sj.onc.1205668
https://doi.org/10.1038/sj.onc.1205668
Publikováno v:
Experimental Cell Research. 275:155-170
Tight junctions are apically localized structures that regulate the passage of small molecules and proteins through intercellular regions of epithelial or endothelial cells. These structures are complex multimolecular assemblages that contain both tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4a52a0da91c14bddffb28b087db546c
https://doi.org/10.1006/excr.2002.5475
https://doi.org/10.1006/excr.2002.5475
Autor:
Lisa M. Toney, Laurence A. Lasky, Donald Dowbenko, Tracy Tang, Amanda Jackson, Alexander L. Dent, David A. Lewin
Publikováno v:
Journal of Biological Chemistry. 277:14255-14265
The activation of the AKT/protein kinase B kinases by mutation of the PTEN lipid phosphatase results in enhanced survival of a diversity of tumors. This resistance to apoptosis is partly accomplished by the inhibition of genetic programs induced by a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98e964ff1e5191e917e0713d47460daf
https://doi.org/10.1074/jbc.m110901200
https://doi.org/10.1074/jbc.m110901200
Publikováno v:
Journal of Biological Chemistry. 277:11352-11361
p21(Cip1/WAF1) (p21), a p53-inducible protein, is a critical regulator of cell cycle and cell survival. p21 binds to and inhibits both the DNA synthesis regulator proliferating cell nuclear antigen and cyclin A/E-CDK2 complexes. Recently, p21 has als
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93211df89466ca278610ac4c25fcf3e7
https://doi.org/10.1074/jbc.m109062200
https://doi.org/10.1074/jbc.m109062200
Publikováno v:
The American Journal of Pathology. 158:809-816
Prostate stem cell antigen (PSCA) is a GPI-anchored membrane protein whose expression is reportedly up-regulated in a majority of human prostate cancers, including advanced stages and metastases. In this study, we investigate the expression pattern o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfcefd75a53d164b64b5d17607516a37
https://doi.org/10.1016/s0002-9440(10)64028-x
https://doi.org/10.1016/s0002-9440(10)64028-x
Autor:
M. Teresa Pisabarro, Germaine Fuh, Sachdev S. Sidhu, Clifford Quan, Laurence A. Lasky, Ying Li
Publikováno v:
Journal of Biological Chemistry. 275:21486-21491
PDZ domains mediate protein-protein interactions at specialized subcellular sites, such as epithelial cell tight junctions and neuronal post-synaptic densities. Because most PDZ domains bind extreme carboxyl-terminal sequences, the phage display meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::233f2fc924e0f54d2415629ecf009496
https://doi.org/10.1074/jbc.275.28.21486
https://doi.org/10.1074/jbc.275.28.21486
Autor:
Yan Wu, Laurence A. Lasky, Qimin Gu, Richard P. Laura, Susan D. Spencer, James Lee, Donald Dowbenko
Publikováno v:
Journal of Biological Chemistry. 275:21477-21485
PTEN/MMAC is a phosphatase that is mutated in multiple human tumors. PTEN/MMAC dephosphorylates 3-phosphorylated phosphatidylinositol phosphates that activate AKT/protein kinase B (PKB) kinase activity. AKT/PKB is implicated in the inhibition of apop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55dc66697588bff1451bc4738ca7d0a6
https://doi.org/10.1074/jbc.m909741199
https://doi.org/10.1074/jbc.m909741199