Zobrazeno 1 - 10
of 50
pro vyhledávání: '"Laurence, B Lovat"'
Autor:
Madeleine H. Williams, Andreas V. Hadjinicolaou, Benjamin C. Norton, Rawen Kader, Laurence B. Lovat
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Lynch syndrome (LS) is an inherited cancer predisposition syndrome associated with high lifetime risk of developing tumours, most notably colorectal and endometrial. It arises in the context of pathogenic germline variants in one of the mismatch repa
Externí odkaz:
https://doaj.org/article/bddf8d5141c34a76b59194e2b7e37b3b
Autor:
Pradeep Bhandari, Laurence B Lovat, Rehan Haidry, Krish Ragunath, Hugh Barr, Clive Stokes, Mohammad Farhad Peerally, Howard Smart, John De Caestecker, Clare Jackson
Publikováno v:
BMJ Open, Vol 13, Iss 1 (2023)
Objectives Strong recruitment and retention into randomised controlled trials involving invasive therapies is a matter of priority to ensure better achievement of trial aims. The BRIDE (Barrett’s Randomised Intervention for Dysplasia by Endoscopy)
Externí odkaz:
https://doaj.org/article/a2c627e57fa44367b82a524d0bc38433
A comparison of epithelial cell content of oral samples estimated using cytology and DNA methylation
Autor:
Yen Ting Wong, Michael A Tayeb, Timothy C. Stone, Laurence B. Lovat, Andrew E. Teschendorff, Rafal Iwasiow, Jeffrey M Craig
Publikováno v:
Epigenetics, Vol 17, Iss 3, Pp 327-334 (2022)
Saliva and buccal samples are popular for epigenome wide association studies (EWAS) due to their ease of collection compared and their ability to sample a different cell lineage compared to blood. As these samples contain a mix of white blood cells a
Externí odkaz:
https://doaj.org/article/7ef3e432403b416ab198b58fec31cb84
Autor:
Kai Man Alexander Ho, Hywel Davies, Ruth Epstein, Paul Bassett, Áine Hogan, Yusuf Kabir, John Rubin, Gee Yen Shin, Jonathan P. Reid, Ryo Torii, Manish K. Tiwari, Ramanarayanan Balachandran, Laurence B. Lovat
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract COVID-19 has restricted singing in communal worship. We sought to understand variations in droplet transmission and the impact of wearing face masks. Using rapid laser planar imaging, we measured droplets while participants exhaled, said ‘
Externí odkaz:
https://doaj.org/article/e1e2bcaf77fc437f88b5559bf7c3bf08
Publikováno v:
BMC Surgery, Vol 21, Iss 1, Pp 1-13 (2021)
Abstract Surgical training in the UK and Ireland has faced challenges following the implementation of the European Working Time Directive and postgraduate training reform. The health services are undergoing a digital transformation; digital technolog
Externí odkaz:
https://doaj.org/article/5f6bfcffb6af478cbf953195409ad02d
Publikováno v:
Frontline Gastroenterology. 14:249-257
The prevalence of the gastro-oesophageal reflux disease (GORD) in the western world is increasing. Uncontrolled GORD can lead to harmful long-term sequela such as oesophagitis, stricture formation, Barrett’s oesophagus and oesophageal adenocarcinom
Autor:
Omer F Ahmad, Evangelos Mazomenos, Francois Chadebecq, Rawen Kader, Mohamed Hussein, Rehan J Haidry, Juana González‐Bueno Puyal, Patrick Brandao, Daniel Toth, Peter Mountney, Ed Seward, Roser Vega, Danail Stoyanov, Laurence B Lovat
Publikováno v:
Journal of Gastroenterology and Hepatology. 38:768-774
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 20:171-182
Modern endoscopy relies on digital technology, from high-resolution imaging sensors and displays to electronics connecting configurable illumination and actuation systems for robotic articulation. In addition to enabling more effective diagnostic and
Autor:
Roisin Sullivan, Susan Heavey, David G Graham, Rachel Wellman, Saif Khan, Sri Thrumurthy, Benjamin S Simpson, Tina Baker, Sarah Jevons, Jose Ariza, Victor Eneh, Hayley Pye, Hayley Luxton, Rifat Hamoudi, Hayley Whitaker, Laurence B Lovat
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229791 (2020)
Saliva represents an ideal matrix for diagnostic biomarker development as it is readily available and requires no invasive collection procedures. However, salivary RNA is labile and rapidly degrades. Previous attempts to isolate RNA from saliva have
Externí odkaz:
https://doaj.org/article/bfb08694d38e4c588b963dcf60b1bbe1
Autor:
Avi Rosenfeld, PhD, David G Graham, MBBS, Sarah Jevons, PhD, Jose Ariza, RGN, Daryl Hagan, MSc, Ash Wilson, BSc, Samuel J Lovat, Sarmed S Sami, MBBS, Omer F Ahmad, MBBS, Marco Novelli, ProfMBChB, Manuel Rodriguez Justo, MBBS, Alison Winstanley, MBBS, Eliyahu M Heifetz, PhD, Mordehy Ben-Zecharia, PhD, Uria Noiman, PhD, Rebecca C Fitzgerald, ProfMBChB, Peter Sasieni, ProfPhD, Laurence B Lovat, ProfMBBS, Karen Coker, Wanfeng Zhao, Kathryn Brown, Beverley Haynes, Tara Nuckcheddy Grant, Massimiliano di Pietro, Eleanor Dewhurst, Bincy Alias, Leanne Mills, Caroline Wilson, Elizabeth Bird-Lieberman, Jan Bornschein, Yean Lim, Kareem Shariff, Roberto Cayado Lopez, Myrna Udarbe, Claire Shaw, Glynis Rose, Ian Sargeant, M Al-Izzi, Roisin Schimmel, Elizabeth Green, Morgan Moorghen, Reshma Kanani, Mariann Baulf, Jayne Butcher, Adil Butt, Steve Bown, Gideon Lipman, Rami Sweis, Vinay Sehgal, Matthew Banks, Rehan Haidry, John Louis-Auguste, Darina Kohoutova, Sarah Kerr, Victor Eneh, Nigel Butter, Haroon Miah, Rommel Butawan, Grace Adesina, Sabrina Holohan, Joan Idris, Nick Hayes, Shajahan Wahed, Nelson Kath Houghton, Marc Hopton, Anne Eastick, Debasis Majumdar, Kassem Manuf, Lyndsey Fieldson, Helen Bailey, Jacobo Fernandez-Sordo Ortiz, Mina Patel, Suzanne Henry, Samantha Warburton, Jonathan White, Lisa Gadeke, Beverley Longhurst, Richmond Abeseabe, Peter Basford, Rupam Bhattacharyya, Scott Elliot, Roisin Bevan, Carly Brown, Philippa Laverick, Gayle Clifford, Anita Gibbons, Julie Ingmire, Abdullah Mawas, Jacquelyn Harvey, Sharon Cave
Publikováno v:
The Lancet: Digital Health, Vol 2, Iss 1, Pp e37-e48 (2020)
Summary: Background: Screening for Barrett's oesophagus relies on endoscopy, which is invasive and few who undergo the procedure are found to have the condition. We aimed to use machine learning techniques to develop and externally validate a simple
Externí odkaz:
https://doaj.org/article/a1c2697d1f57456aa1b1b0078466e610