Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Lauren Zebertavage"'
Autor:
Lauren Zebertavage, Allison Schopf, Megan Nielsen, Joel Matthews, Amy K. Erbe, Taylor J. Aiken, Sydney Katz, Claire Sun, Cole M. Witt, Alexander L. Rakhmilevich, Paul M. Sondel
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 9, p 2561 (2024)
Background: Incorporating GD2-targeting monoclonal antibody into post-consolidation maintenance therapy has improved survival for children with high-risk neuroblastoma. However, ~50% of patients do not respond to, or relapse following, initial treatm
Externí odkaz:
https://doaj.org/article/733faad25dac4283bca0cc877a4c2049
Autor:
Terry R. Medler, Gwen Kramer, Shelly Bambina, Andrew J. Gunderson, Alejandro Alice, Tiffany Blair, Lauren Zebertavage, Thomas Duhen, Rebekka Duhen, Kristina Young, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-17 (2023)
Abstract Tissue resident memory (Trm) CD8 T cells infiltrating tumors represent an enriched population of tumor antigen-specific T cells, and their presence is associated with improved outcomes in patients. Using genetically engineered mouse pancreat
Externí odkaz:
https://doaj.org/article/71fc1c1f57f6476d9ed4a952100a3793
Autor:
Tiffany C. Blair, Alejandro F. Alice, Lauren Zebertavage, Marka R. Crittenden, Michael J. Gough
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Analysis of tumor infiltration using conventional methods reveals a snapshot view of lymphocyte interactions with the tumor environment. However, lymphocytes have the unique capacity for continued recirculation, exploring varied tissues for the prese
Externí odkaz:
https://doaj.org/article/bfbeee4e26dc4d0a92e5e24aef9d72df
Autor:
Marka R. Crittenden, Lauren Zebertavage, Gwen Kramer, Shelly Bambina, David Friedman, Victoria Troesch, Tiffany Blair, Jason R. Baird, Alejandro Alice, Michael J. Gough
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-15 (2018)
Abstract Radiation therapy is a source of tumor antigen release that has the potential to serve as an endogenous tumor vaccination event. In preclinical models radiation therapy synergizes with checkpoint inhibitors to cure tumors via CD8 T cell resp
Externí odkaz:
https://doaj.org/article/5f487b6ccc674a53808df9b8692dc7ec
Autor:
Lauren Zebertavage, Shelly Bambina, Jessica Shugart, Alejandro Alice, Kyra D Zens, Peter Lauer, Bill Hanson, Michael J Gough, Marka R Crittenden, Keith S Bahjat
Publikováno v:
PLoS ONE, Vol 14, Iss 1, p e0209153 (2019)
Dysregulated signaling via the epidermal growth factor receptor (EGFR)-family is believed to contribute to the progression of a diverse array of cancers. The most common variant of EGFR is EGFRvIII, which results from a consistent and tumor-specific
Externí odkaz:
https://doaj.org/article/4c25820ef0e34565971f0f5e86283508
Autor:
Andrew J Gunderson, Tomoko Yamazaki, Kayla McCarty, Michaela Phillips, Alejandro Alice, Shelly Bambina, Lauren Zebertavage, David Friedman, Benjamin Cottam, Pippa Newell, Michael J Gough, Marka R Crittenden, Pieter Van der Veken, Kristina H Young
Publikováno v:
PLoS ONE, Vol 14, Iss 2, p e0211117 (2019)
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a fibrotic stroma with a poor lymphocyte infiltrate, in part driven by cancer-associated fibroblasts (CAFs). CAFs, which express fibroblast activation protein (FAP), contribute to immune esc
Externí odkaz:
https://doaj.org/article/2e99967ed537478dbb6b319acc802e12
Autor:
Amy K. Erbe, Arika S. Feils, Alina Hampton, Dan Spiegelman, Noah Tsarovsky, Anna Hoefges, Peter M. Carlson, Alex Pieper, Callie Haertle, Mackenzie Heck, Sabrina VandenHeuvel, Lizzie Frankel, Lauren Zebertavage, Alexa Heaton, Zachary S. Morris, Ravi Patel, Alexander Rakhmilevich, Paul M. Sondel
Publikováno v:
Cancer Research. 83:4142-4142
Using an in situ vaccine (ISV) regimen that includes a combination therapy of radiation (given at D0) with hu14.18-IL2 immunocytokine [anti-GD2 linked to IL2, (Anyxis Immuno-Oncology GmbH (Austria)); given at D5-D9], we can cure mice of large B78 mel
Autor:
Taylor J Aiken, Amy K Erbe, Lauren Zebertavage, David Komjathy, Arika S Feils, Matthew Rodriguez, Ashley Stuckwisch, Stephen D Gillies, Zachary S Morris, Jen Birstler, Alexander L Rakhmilevich, Paul M Sondel
Publikováno v:
Journal for immunotherapy of cancer. 10(5)
BackgroundMost pediatric cancers are considered immunologically cold with relatively few responding to immune checkpoint inhibition. We recently described an effective combination radio-immunotherapy treatment regimen (combinationadaptive-innate immu
Autor:
Amy K. Erbe, Arika Feils, Mackenzie Heck, Sabrina VandenHeuvel, Julianna Castillo, Alina Hampton, Lizzie Frankel, Anna Hoefges, Peter Carlson, Alex A. Pieper, Taylor Aiken, Lauren Zebertavage, David Komjathy, Dan Spiegelman, Noah Tsarovsky, Zachary S. Morris, Ravi Patel, Alexander Rakhmilevich, Paul M. Sondel
Publikováno v:
Cancer Research. 82:1385-1385
Introduction: Using an in situ vaccine (ISV) regimen consisting of radiation combined with immunocytokine (tumor-targeting mAb linked to IL2), we can cure mice of well established B78 melanoma tumors (B78s). Mice cured of their B78s with ISV demonstr
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020)
Radiation therapy has been shown to enhance the efficacy of various T cell-targeted immunotherapies that improve antigen-specific T cell expansion, T regulatory cell depletion, or effector T cell function. Additionally, radiation therapy has been pro