Výsledky vyhledávání - "Lauren W, Wang"

Akademický článek

Proteolysis of fibrillin-2 microfibrils is essential for normal skeletal development

Autor: Timothy J Mead, Daniel R Martin, Lauren W Wang, Stuart A Cain, Cagri Gulec, Elisabeth Cahill, Joseph Mauch, Dieter Reinhardt, Cecilia Lo, Clair Baldock, Suneel S Apte

Publikováno v: eLife, Vol 11 (2022)

The embryonic extracellular matrix (ECM) undergoes transition to mature ECM as development progresses, yet few mechanisms ensuring ECM proteostasis during this period are known. Fibrillin microfibrils are macromolecular ECM complexes serving structur

Externí odkaz: https://doaj.org/article/5a97c8b12bf54934ac67208635fbd524

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Akademický článek

Secreted metalloproteases ADAMTS9 and ADAMTS20 have a non-canonical role in ciliary vesicle growth during ciliogenesis

Autor: Sumeda Nandadasa, Caroline M. Kraft, Lauren W. Wang, Anna O’Donnell, Rushabh Patel, Heon Yung Gee, Kay Grobe, Timothy C. Cox, Friedhelm Hildebrandt, Suneel S. Apte

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Ciliogenesis is a complex process requiring hundreds of molecules, although few secreted proteins have been implicated. Here, the authors show that the secreted metalloproteases ADAMTS9 and ADAMTS20 intracellularly regulate ciliogenesis from unique p

Externí odkaz: https://doaj.org/article/ab5baac1ec5848ec9b9f690a16ccfcb8

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Supplementary Figure Legends from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Autor: Jay S. Wunder, Benjamin A. Alman, Karen McGovern, Suneel S. Apte, Lauren W. Wang, Jennifer Proctor, John Keilty, Qingxia Wei, Raymond Poon, Heather Whetstone, Chang Ye Yale Wang, S. Amanda Ali, Puviindran Nadesan, Veronica T. Campbell

PDF - 62K, Legends for Supplementary Figures 1 and 2.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0031bc8b77d1f2a721eb5f234c31d844
https://doi.org/10.1158/1535-7163.22500409

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Supplementary Table 1 from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

PDF - 71K, A list of the solid tumor xenografts tested for regulation of human or murine Gli1 following IPI-926 treatment, as measured by q-RT-PCR on whole tumor RNA extracts.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::638ed50f91999fe61a2302b662e42782
https://doi.org/10.1158/1535-7163.22500406.v1

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Supplementary Figure 1 from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

PDF - 516K, Hh signaling in normal mouse chondrocytes is inhibited by IPI-926 treatment and leads to growth plate closure. A. Active control growth plate with a normal appearance. B. Corresponding growth plate from an IPI-926 treated mouse shows prem

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44aefa78616bb576a241604483aa4a6f
https://doi.org/10.1158/1535-7163.22500415

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Supplementary Figure 2 from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

PDF - 427K, Representative image of a hematoxylin and esosin stained primary chondrosarcoma xenograft. The image shows a typical appearance of low cellularity (blue nuclei) with considerable extracellular matrix between the cells and no obvious tumor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::702ae81a80dc902a1a4f76b5b7b3c9ac
https://doi.org/10.1158/1535-7163.22500412

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Data from Hedgehog Pathway Inhibition in Chondrosarcoma Using the Smoothened Inhibitor IPI-926 Directly Inhibits Sarcoma Cell Growth

Hedgehog (Hh) pathway inhibition in cancer has been evaluated in both the ligand-independent and ligand-dependent settings, where Hh signaling occurs either directly within the cancer cells or within the nonmalignant cells of the tumor microenvironme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a69e28631a45293ed007035d20a8495d
https://doi.org/10.1158/1535-7163.c.6536443

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Akademický článek

Adamtsl2 deletion results in bronchial fibrillin microfibril accumulation and bronchial epithelial dysplasia – a novel mouse model providing insights into geleophysic dysplasia

Autor: Dirk Hubmacher, Lauren W. Wang, Robert P. Mecham, Dieter P. Reinhardt, Suneel S. Apte

Publikováno v: Disease Models & Mechanisms, Vol 8, Iss 5, Pp 487-499 (2015)

Mutations in the secreted glycoprotein ADAMTSL2 cause recessive geleophysic dysplasia (GD) in humans and Musladin–Lueke syndrome (MLS) in dogs. GD is a severe, often lethal, condition presenting with short stature, brachydactyly, stiff skin, joint

Externí odkaz: https://doaj.org/article/e8534e7b6a6648f88a2245a4e021bde7

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