Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Lauren Trull"'
Autor:
Albert C. Lockhart, Andrea Wang-Gillam, Michael J. Naughton, Joel Picus, Rama Suresh, Feng Gao, Gretel Terrero, Maria Q. Baggstrom, Lauren Trull, Cynthia Ma, Paula M. Fracasso, Benjamin R. Tan, Manik Amin, Stephanie Belanger
Publikováno v:
American Journal of Clinical Oncology. 44:443-448
Introduction The mammalian target of rapamycin (mTOR) is a downstream mediator in the phosphatidylinositol 3-kinase/Akt signaling pathway, and plays a central role in cell proliferation, growth, differentiation, migration, and survival. Temsirolimus
Autor:
Jennifer Frye, Richard Laforest, Barry A. Siegel, Jeanne Mendell, Lauren Trull, Farrokh Dehdashti, Joel Picus, Syed Mahmood, Madhuri Desai, Yongjian Liu, A. Craig Lockhart, Michael J. Welch, Stefanie Belanger
Publikováno v:
Molecular Imaging and Biology. 18:446-453
The purpose of this study was to evaluate the safety, dosimetry, and apparent receptor occupancy (RO) of [(64)Cu]DOTA-patritumab, a radiolabeled monoclonal antibody directed against HER3/ERBB3 in subjects with advanced solid tumors.Dosimetry subjects
Autor:
Andrea Wang-Gillam, A. Craig Lockhart, David J. Mauro, Lauren Trull, Darcy A. Hille, Cheryl A. Pickett, Jared Lunceford, Mark N. Stein, Smitha S. Krishnamurthi, Susan Minton, Manik Amin, Patricia LoRusso
Background MK-5108 is a potent/highly selective Aurora A kinase inhibitor. Methods A randomized Phase I study of MK-5108, administered p.o. BID Q12h on days 1-2 in 14-21 day cycles either alone (MT; Panel1/n = 18; 200 to 1800 mg) or in combination (C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::799f6ac723e235ef759cc12d434c7aec
https://europepmc.org/articles/PMC4806784/
https://europepmc.org/articles/PMC4806784/
Autor:
Benjamin R. Tan, Tibu Mwandoro, Xuntian Jiang, Allison N. Creekmore, Wooin Lee, A. Craig Lockhart, Andrea Wang-Gillam, Maria Q. Baggstrom, Lauren Trull, Nilay Thakkar, Feng Gao, Stefanie Belanger, Rama Suresh, Joel Picus, Michael Naughton, Paula M. Fracasso, Cynthia X. Ma, Kerry J. Williams
Publikováno v:
Cancer Chemotherapy and Pharmacology
This study aimed to determine the maximum-tolerated dose and dose-limiting toxicities of pegylated liposomal doxorubicin (PLD) in combination with temsirolimus (T) in patients with refractory solid tumors. Using a standard “3+3” dose escalation d
Autor:
Stefanie Belanger, Jeanne Mendell, Syed Mahmood, Farrokh Dehdashti, Joel Picus, Andrea Wang-Gillam, Michael J. Welch, Barry A. Siegel, Richard Laforest, Albert C. Lockhart, Madhuri Desai, Yongjian Liu, Lauren Trull
Publikováno v:
Cancer Research. 74:5443-5443
Background: Patritumab (P) is a HER3-specific human mAB that promotes receptor downregulation, inhibits ligand binding and tumor growth in xenografts models, and is safe in humans. The radioisotope 64Cu conjugated with P with a DOTA chelate, was conf