Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lauren T. Hewitt"'
Autor:
George R. Bjorklund, Katherina P. Rees, Kavya Balasubramanian, Lauren T. Hewitt, Kenji Nishimura, Jason M. Newbern
Publikováno v:
Disease Models & Mechanisms, Vol 17, Iss 6 (2024)
Externí odkaz:
https://doaj.org/article/4bae5a7266df4e65a3b97c0d36678ef0
Publikováno v:
Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Abstract Inhibitory interneurons are among the most diverse cell types in the brain; the hippocampus itself contains more than 28 different inhibitory interneurons. Interneurons are typically classified using a combination of physiological, morpholog
Externí odkaz:
https://doaj.org/article/7f26def9d5ac4bb3af9550ade1b5b3d7
Autor:
Sarah E. Mennenga, Leslie C. Baxter, Itamar S. Grunfeld, Gene A. Brewer, Leona S. Aiken, Elizabeth B. Engler-Chiurazzi, Bryan W. Camp, Jazmin I. Acosta, B. Blair Braden, Keley R. Schaefer, Julia E. Gerson, Courtney N. Lavery, Candy W.S. Tsang, Lauren T. Hewitt, Melissa L. Kingston, Stephanie V. Koebele, K. Jake Patten, B. Hunter Ball, Michael K. McBeath, Heather A. Bimonte-Nelson
Publikováno v:
Frontiers in Behavioral Neuroscience, Vol 8 (2014)
We constructed an 11-arm, walk-through, human radial-arm maze (HRAM) as a translational instrument to compare existing methodology in the areas of rodent and human learning and memory research. The HRAM, utilized here, serves as an intermediary test
Externí odkaz:
https://doaj.org/article/203d1c4480fa4ea5a28775d45ff0a6cb
Autor:
Lauren T. Hewitt, Darrin H. Brager
Fragile X syndrome is the most common inherited form of intellectual disability and the leading monogenetic cause of autism. Studies in mouse models of autism spectrum disorders, including the Fmr1 knockout (FX) mouse, suggest that an imbalance betwe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8227af5f7e4208da154ca22c562d64a5
https://doi.org/10.1101/2022.12.20.521268
https://doi.org/10.1101/2022.12.20.521268
Publikováno v:
Physiological Reports, Vol 9, Iss 9, Pp n/a-n/a (2021)
Inhibitory interneurons are among the most diverse cell types in the brain; the hippocampus itself contains more than 28 different inhibitory interneurons. Interneurons are typically classified using a combination of physiological, morphological and
Autor:
Heather A. Bimonte-Nelson, Shruti Patel, Loretta P. Mayer, Stephanie V. Koebele, Lauren T. Hewitt, Mallori L. Poisson, Sarah E. Mennenga, Cheryl A. Dyer
Publikováno v:
Horm Behav
17β-estradiol (E2)-containing hormone therapy is a safe, effective way to alleviate unwanted menopause symptoms. Preclinical research has focused upon the role of E2 in learning and memory using a surgically menopausal rodent model whereby the ovari
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::317374aadd4b14dec0c1805179627b90
https://europepmc.org/articles/PMC8032560/
https://europepmc.org/articles/PMC8032560/
Autor:
Carter W. Daniels, Trent Anderson, David M. Treiman, Michael Olive, Jason M. Newbern, Katherina P. Rees, Kenji J. Nishimura, Sara J Knowles, Shiv Shah, George R. Bjorklund, Guohui Li, Federico Sanabria, Lauren T. Hewitt, Noah R. Fry, Steven Marsh, Tanya A. Gupta, Michael C. Holter, William D. Snider
Publikováno v:
Cereb Cortex
Many developmental syndromes have been linked to genetic mutations that cause abnormal ERK/MAPK activity; however, the neuropathological effects of hyperactive signaling are not fully understood. Here, we examined whether hyperactivation of MEK1 modi
Autor:
Ryoko Hiroi, Sarah E. Mennenga, Cheryl A. Dyer, Mallori L. Poisson, Heather A. Bimonte-Nelson, Lauren T. Hewitt, Loretta P. Mayer, Alicia M. Quihuis, Stephanie V. Koebele, Christina George, Catherine G. Carson, Leona S. Aiken, Laurence M. Demers
Publikováno v:
Hormones and Behavior. 87:96-114
Cognitive changes that occur during mid-life and beyond are linked to both aging and the menopause transition. Studies in women suggest that the age at menopause onset can impact cognitive status later in life; yet, little is known about memory chang
Autor:
Heather A. Bimonte-Nelson, Toshiyuki Araki, William D. Snider, Benjamin G. Neel, Jason M. Newbern, Lei Xing, Michael C. Holter, Cheryl D. Conrad, Lauren T. Hewitt, Stephanie V. Koebele, Jessica M. Judd
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 15, Iss 4, p e1008108 (2019)
PLoS Genetics, Vol 15, Iss 4, p e1008108 (2019)
RASopathies are a family of related syndromes caused by mutations in regulators of the RAS/Extracellular Regulated Kinase 1/2 (ERK1/2) signaling cascade that often result in neurological deficits. RASopathy mutations in upstream regulatory components
Autor:
Matthew J. Huentelman, Matt De Both, Jason Caselli, Jason J. Corneveaux, Lauren T. Hewitt, Mari N. Willeman, Ashley L. Siniard, Candy W. S. Tsang, Heather A. Bimonte-Nelson, B. Blair Braden, Sarah E. Mennenga
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 6, p e0198256 (2018)
PLoS ONE, Vol 13, Iss 6, p e0198256 (2018)
Enzastaurin is a Protein Kinase C-β selective inhibitor that was developed to treat cancers. Protein Kinase C-β is an important enzyme for a variety of neuronal functions; in particular, previous rodent studies have reported deficits in spatial and