Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Lauren Smithee"'
Autor:
Lauren Smithee, April Few‐Demo
Publikováno v:
Journal of Marital and Family Therapy.
Autor:
Lisa A. Hasvold, Steven W. Elmore, Nirupama B. Soni, Leiming Li, Yu Shen, George S. Sheppard, Terrance J. Magoc, Carol K. Wada, Dachun Liu, Sanjay C. Panchal, Scott E. Warder, Chaohong Sun, Keith F. McDaniel, Lauren Smithee, Xiaoyu Lin, Daniel H. Albert, Xiaoli Huang, Chang H. Park, Le Wang, Peter Kovar, F. Greg Buchanan, Warren M. Kati, Robert A. Mantei, Robbert Hubbard, Andrew M. Petros, Steven D. Fidanze, Denise Wilcox, John K. Pratt
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(10)
An NMR fragment screen for binders to the bromodomains of BRD4 identified 2-methyl-3-ketopyrroles 1 and 2. Elaboration of these fragments guided by structure-based design provided lead molecules with significant activity in a mouse tumor model. Furth