Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Lauren See"'
Autor:
Maxime WC Rousseaux, Maria de Haro, Cristian A Lasagna-Reeves, Antonia De Maio, Jeehye Park, Paymaan Jafar-Nejad, Ismael Al-Ramahi, Ajay Sharma, Lauren See, Nan Lu, Luis Vilanova-Velez, Tiemo J Klisch, Thomas F Westbrook, Juan C Troncoso, Juan Botas, Huda Y Zoghbi
Publikováno v:
eLife, Vol 5 (2016)
Several neurodegenerative diseases are driven by the toxic gain-of-function of specific proteins within the brain. Elevated levels of alpha-synuclein (α-Syn) appear to drive neurotoxicity in Parkinson's disease (PD); neuronal accumulation of tau is
Externí odkaz:
https://doaj.org/article/93410c1594ba4a58af0e34be80ba8d24
Autor:
Cristian A Lasagna-Reeves, Maxime WC Rousseaux, Marcos J Guerrero-Munoz, Luis Vilanova-Velez, Jeehye Park, Lauren See, Paymaan Jafar-Nejad, Ronald Richman, Harry T Orr, Rakez Kayed, Huda Y Zoghbi
Publikováno v:
eLife, Vol 4 (2015)
Previously, we reported that ATXN1 oligomers are the primary drivers of toxicity in Spinocerebellar ataxia type 1 (SCA1; Lasagna-Reeves et al., 2015). Here we report that polyQ ATXN1 oligomers can propagate locally in vivo in mice predisposed to SCA1
Externí odkaz:
https://doaj.org/article/d002a7e384314590be223bbcbc560076
Autor:
Alexander H. Settle, Benjamin Y. Winer, Miguel M. de Jesus, Lauren Seeman, Zhaoquan Wang, Eric Chan, Yevgeniy Romin, Zhuoning Li, Matthew M. Miele, Ronald C. Hendrickson, Daan Vorselen, Justin S. A. Perry, Morgan Huse
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Phagocytosis is an intensely physical process that depends on the mechanical properties of both the phagocytic cell and its chosen target. Here, we employed differentially deformable hydrogel microparticles to examine the role of cargo rigid
Externí odkaz:
https://doaj.org/article/7bde948fab0947f0a3ebd774da92a46f
Autor:
Shuang Hao, Antonia De Maio, Cristian A. Lasagna-Reeves, Jianrong Tang, Luis Vilanova-Velez, Huda Y. Zoghbi, Maxime W.C. Rousseaux, Lauren See, Jeehye Park, Zhenyu Wu, Juan C. Troncoso, Paymaan Jafar-Nejad, Thomas F. Westbrook, Maria de Haro, Larissa Nitschke, Juan Botas, Ismael Al-Ramahi
Publikováno v:
Neuron. 92:407-418
Many neurodegenerative proteinopathies share a common pathogenic mechanism: the abnormal accumulation of disease-related proteins. As growing evidence indicates that reducing the steady-state levels of disease-causing proteins mitigates neurodegenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7603136e3b51989f3f2f9b2cc96b0cc3
https://doi.org/10.1016/j.neuron.2016.09.022
https://doi.org/10.1016/j.neuron.2016.09.022
Autor:
Paula Morris, Rani Sachdev, Kevin Ying, Rebecca Macintosh, Kerith-Rae Dias, Holly Dubbs, Jiang Tao, Amy M. Breman, Mark J. Cowley, Oana Caluseriu, Laura M McDonell, Oksana Suchowersky, Li Wang, Berivan Baskin, Tony Roscioli, Elizabeth E. Palmer, Vincenzo A. Gennarino, Carolyn J. Adamski, Ann M. E. Bye, Chun-An Chen, Jessica A. Panzer, Michael Cardamone, Jianrong Tang, Huda Y. Zoghbi, Marcel E. Dinger, Ying Zhu, Edwin P. Kirk, Amanda Koire, J. Lloyd Holder, Megan T. Cho, Lindsay B. Henderson, Ute Moog, Lauren See, Kym M. Boycott, Tejaswi Kandula, Pawel Stankiewicz, Jill A. Rosenfeld, Shuang Hao, Olivier Lichtarge, Christian P. Schaaf, Arran McBride
Publikováno v:
Epilepsy Currents
A Mild PUM1 Mutation Is Associated With Adult-Onset Ataxia, Whereas Haploinsufficiency Causes Developmental Delay and Seizures Gennarino VA, Palmer EE, McDonell LM, et al. Cell. 2018;172(5):924-936.e11. doi:10.1016/j.cell.2018.02.006. Certain mutatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd0243e6571b7b879b3870a5a81bc46c
https://hdl.handle.net/10453/128125
https://hdl.handle.net/10453/128125
Autor:
Maxime W.C. Rousseaux, Luis Vilanova-Velez, Tiemo J. Klisch, Jeehye Park, Huda Y. Zoghbi, Maria de Haro, Cristian A. Lasagna-Reeves, Nan Lu, Thomas F. Westbrook, Juan Botas, Ismael Al-Ramahi, Paymaan Jafar-Nejad, Lauren See, Antonia De Maio, Juan C. Troncoso, Ajay Sharma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9122ffa226037828fa0608758bbe27c
https://doi.org/10.7554/elife.19809.028
https://doi.org/10.7554/elife.19809.028
Autor:
Maxime W.C. Rousseaux, Harry T. Orr, Luis Vilanova-Velez, Rakez Kayed, Ronald Richman, Huda Y. Zoghbi, Lauren See, Paymaan Jafar-Nejad, Jeehye Park, Marcos J. Guerrero-Muñoz, Cristian A. Lasagna-Reeves
Publikováno v:
eLife
eLife, Vol 4 (2015)
eLife, Vol 4 (2015)
Previously, we reported that ATXN1 oligomers are the primary drivers of toxicity in Spinocerebellar ataxia type 1 (SCA1; Lasagna-Reeves et al., 2015). Here we report that polyQ ATXN1 oligomers can propagate locally in vivo in mice predisposed to SCA1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812848dd8a20d785b16d298657b929ee
https://doi.org/10.7554/elife.10891
https://doi.org/10.7554/elife.10891
Autor:
Luis Vilanova-Velez, Ronald Richman, Harry T. Orr, Maxime W.C. Rousseaux, Cristian A. Lasagna-Reeves, Huda Y. Zoghbi, Jeehye Park, Paymaan Jafar-Nejad, Lauren See, Rakez Kayed, Marcos J. Guerrero-Muñoz
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b85686411745a362b97b25857b97e5a4
https://doi.org/10.7554/elife.10891.010
https://doi.org/10.7554/elife.10891.010
Long-lived crowded-litter mice exhibit lasting effects on insulin sensitivity and energy homeostasis
Autor:
Manuel Blandino-Rosano, Andrzej Bartke, Lynda Elghazi, Ernesto Bernal-Mizrachi, Taylor Landeryou, Lauren See, Daniel L. Meister, Gillian Cady, Marianna Sadagurski, Richard A. Miller
The action of nutrients on early postnatal growth can influence mammalian aging and longevity. Recent work has demonstrated that limiting nutrient availability in the first 3 wk of life [by increasing the number of pups in the crowded-litter (CL) mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3f1eea1e3c0e9a3caae5949d112a5b
https://europepmc.org/articles/PMC4042097/
https://europepmc.org/articles/PMC4042097/
Publikováno v:
Frontiers in Ecology and Evolution, Vol 10 (2022)
Intersexual dominance (dominance between the sexes) is often assumed to be binary with species categorized as either male- or female-dominant. Yet in many species, the degree of intersexual dominance falls somewhere in the middle of these two extreme
Externí odkaz:
https://doaj.org/article/9c5e55d2efce4bd48c5a5dd041ee9846