Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lauren Schwimmer"'
Autor:
Irene Tang, Lauren Schwimmer, Shenda Gu, Wei Wei Prior, Hieu Van Tran, Allan Chan, Anna McClain, Christopher C. Fraser, Chunyan Sun, Meimei Si, Guijiang Wang, Yunxia Zhao, Ning Zhang, Jiayu Fu, Mengxin Liu, Chuanzeng Cao, Shihao Chen
Publikováno v:
Frontiers in Drug Discovery, Vol 3 (2023)
Cell surface molecules PD-L1 and CD47 are potent inhibitors of adaptive and innate anti-cancer immunity. We sought to generate a safe, therapeutic, bispecific antibody specifically targeting, and blocking both PD-L1 and CD47 inhibitory activity. Nove
Externí odkaz:
https://doaj.org/article/ea6e81876bdd4c2797c21b733c8f5700
Autor:
Irene Tang, Lauren Schwimmer, Monica Jin, Shenda Gu, Wei Wei Prior, Arianne Capacio, Hieu V. Tran, Allan Chan, Anna McClain, Shihao Chen, Chuanzeng Cao, Xiaoran Wu, Yanling Xu, Dongmei Guan, Xi Chen, Xianli Su
Publikováno v:
Cancer Research. 82:3504-3504
Cytokines are potent stimulators of the immune system and have long been investigated and used as therapeutics to treat cancer. However, free cytokines have short half-life and the lack of tumor targeting often results in systemic toxicity. IL-15 is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3b9c2894a3cec74b66d166369a3a2f80
https://doi.org/10.1158/1538-7445.am2022-3504
https://doi.org/10.1158/1538-7445.am2022-3504
Autor:
Irene Tang, Lauren Schwimmer, Shenda Gu, Wei Wei Prior, Hieu V. Tran, Allan Chan, Anna McClain, Shihao Chen, Chuanzeng Cao, Chunyan Sun, Meimei Si, Guijiang Wang
Publikováno v:
Cancer Research. 82:2894-2894
Upregulation of CD47, a “Do Not Eat Me” signal, is observed in nearly all solid and hematological malignancies. Engagement of CD47 on tumor cells with SIRPα on macrophages inhibits phagocytosis of tumor cells. Anti-CD47 antibodies block the CD47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43fa706132a8d75f31d0b35fc5f16a20
https://doi.org/10.1158/1538-7445.am2022-2894
https://doi.org/10.1158/1538-7445.am2022-2894
Autor:
Anna McClain, Lauren Schwimmer, Weiwei W. Prior, Hieu Tran, Aaron Kurtzman, Shenda Gu, Zijie Cai, Irene Tang, Monica Jin, Chen Shihao, Allan Chan
Publikováno v:
Cancer Research. 80:4541-4541
Leucine-rich repeat containing 15 (LRRC15) antigen is highly expressed on both stromal fibroblasts of multiple solid tumors and on cancer cells of mesenchymal origin. As its expression is very low in normal tissues, targeting LRRC15 has shown therape
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9cfaf7d366e0005b967abd4af4389279
https://doi.org/10.1158/1538-7445.am2020-4541
https://doi.org/10.1158/1538-7445.am2020-4541
Autor:
Lauren Schwimmer, Hassan Issafras, Hoa M. Giang, Chung-Leung Chan, David J. Bohmann, Toshihiko Takeuchi, Nithin B. Reddy, Raphael Levy, Kiran Ahluwalia, Arnold Horwitz
Publikováno v:
Journal of Immunological Methods. 394(1-2):10-21
Improper protein folding or aggregation can frequently be responsible for low expression and poor functional activity of antibody fragments secreted into the Escherichia coli periplasm. Expression issues also can affect selection of antibody candidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::beae410ee10e905080bf5fd67760b245
Autor:
David Chemla-Vogel, Hua-Feng Kuan, Fangjiu Zhang, John W. Beaber, Betty Huang, Pamela Toy, Isaac Rondon, Lauren Schwimmer, Eric M. Tam, Hoa Giang, Daniel Bedinger, David J. Bohmann, Susan R. Watson, Nithin B. Reddy, Robyn Cotter, Francis V. Dy
Publikováno v:
Journal of Immunological Methods. 391(1-2):60-71
Phage display antibody libraries have a proven track record for the discovery of therapeutic human antibodies, increasing the demand for large and diverse phage antibody libraries for the discovery of new therapeutics. We have constructed naïve anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee701668f29d54482ebfabaebcca53c4